Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

Abstract

Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains a significant challenge to fabricate highly efficient nanozymes acting in the tumor microenvironment. Herein, we develop a bimetallic nanozyme (Pt50Sn50) with the photothermal enhancement of dual enzymatic activities for tumor catalytic therapy. The structures and activities of PtSn bimetallic nanoclusters (BNCs) with different Sn content are explored and evaluated systematically. Experimental comparisons show that the Pt50Sn50 BNCs exhibit the highest activities among all those investigated, including enzymatic activity and photothermal property, due to the generation of SnO2–x with oxygen vacancy (Ovac) sites on the surface of Pt50Sn50 BNCs. Specifically, the Pt50Sn50 BNCs exhibit photothermal-enhanced peroxidase-like and catalase-like activities, as well as a significantly enhanced anticancer efficacy in both multicellular tumor spheroids and in vivo experiments. Due to the high X-ray attenuation coefficient and excellent light absorption property, the Pt50Sn50 BNCs also show dual-mode imaging capacity of computed tomography and photoacoustic imaging, which could achieve in vivo real-time monitoring of the therapeutic process. Therefore, this work will advance the development of noble-metal nanozymes with optimal composition for efficient tumor catalytic therapy.

Bioinspired Near-Full Transmittance MgF2 Window for Infrared Detection in Extremely Complex Environments

“…Infrared thermal imaging technology was initially utilized in the military. With the development of science and technology, it has gradually emerged in other fields like medicine, power, construction, aviation, transportation, agriculture, etc. − For example, infrared thermography is used to diagnose the possibility of suffering from cancer by analyzing abnormalities in infrared images of the human body. − Usually, the resolution and noise immunity of the infrared images are important factors that affect the accuracy of the diagnosis. Also, some specific applications raise extremely high requirements for infrared thermal imaging technology, such as infrared monitoring in harsh environments and high-speed infrared-guided. , …”

Tailoring dual drug-backboned polyurethane prodrug nanoparticles as all-in-one nanomedicine for precise multimodal imaging-guided PTT-chemotherapy

“…Photothermal therapy (PTT) has emerged as a booming research field for cancer treatment due to its advantages such as noninvasive nature, high spatiotemporal selectivity, low side effects, and negligible drug resistance. 12–19 PTT can produce heat conversion under NIR irradiation, and finally induce local hyperthermia in the tumor site with minimum harm to surrounding healthy tissue. 20 In particular, various NIR-absorbing nanomaterials, including gold nanoparticles, 21 black phosphorus, carbon nanomaterials, 22 MoS 2 nanomaterials, 23 Pd nanosheets, copper sulfide nanoparticles, 24,25 polymeric nanoparticles ( e.g.…”

Supramolecular Nanozyme System Based on Polydopamine and Polyoxometalate for Photothermal-Enhanced Multienzyme Cascade Catalytic Tumor Therapy

“…Temperature modification is an additional crucial modulator that can be used to alter the catalytic activity of nanozymes. Photothermal therapy (PTT) combined with nanozymes has the potential to increase catalytic activity and therapeutic efficacy via photonic hyperthermia. – This strategy may result in a synergistic effect in the treatment of cancers by combining PTT and tumor nanocatalytic therapy. However, the research and design of PTT-enhanced cascade catalytic nanozyme systems constitute a significant task as they require a harmonious interplay between a plethora of catalytic entities, complex synthetic techniques, and the incorporation of varied biocompatible materials.…”