Dual-Mode Avocado-like All-Iron Nanoplatform for Enhanced T₁/T₂ MRI-Guided Cancer Theranostic Therapy

Abstract

Development of T1/T2 dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional contrast agents can suffer from toxicity and lack any ability to treat cancer. An all-iron T1/T2 MR imaging agent with photothermal and drug delivery capability would overcome these issues. Here, an avocado-like Fe3+/Fe2O3 composed T1-T2 dual-mode contrast agent based on Fe-TA coordination network (CNMN) is developed. This material possesses suitable longitudinal and transverse relaxation coefficients. Moreover, the strong heat generation property of Fe-TA endows CNMN with the capability to act as a potent photothermal agent. Furthermore, CNMN can also act as an effective delivery platform for the chemotherapeutic drug doxorubicin (DOX) to achieve high effective chemo-photothermal combination therapy. The work demonstrates reliable T1-T2 MRI-guided chemo-photothermal therapy for safe and effective clinical application.

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

“…[236][237][238][239][240][241][242][243][244][245][246][247][248][249][250][251] Moreover, inspired by the coordination interactions between various metal ions and polyphenols, researchers have also provided a number of functional MPNs to engineer multifunctional nanosystems. [252][253][254][255][256][257][258][259] Here, we have reviewed the structures and classification of natural polyphenols, the synthesis and properties of the polyphenol-containing nanomaterials, and various biomedical applications of polyphenol-based nanosystems. Some typical examples of the recent biomedical studies on polyphenol-containing NPs are summarized in Table 1 (non-MPN polyphenol-containing NPs) and Table 2 (MPN-containing NPs).…”

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

“…Apart from these potential anticancer applications, Fe‐containing compounds can be applied as MRI contrast agents and Fe 2+/3+ complexes have been validated as excellent candidates for PTT. [ 44 , 122 ] Fe has a variety of advantages for biomedical applications owing to its natural abundance and essential role in diverse life processes of the human body.…”

Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles

“…Specifically, Fe–TA was adhered to polydopamine-modified Fe 2 O 3 (Fe 2 O 3 @PDA), which was further coated with PVP to form the coordination network magnetic nanoparticles. The PDA layer could function as a separator to avoid the undesired interference between T1 and T2 imaging ( Figure 6 ) [ 70 ]. In another report, ultrasmall Fe@Fe 3 O 4 nanoparticles were designed and synthesized as T1–T2 dual-mode MRI contrast agents for accurate tumor imaging.…”