Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated -11,377 G adiponectin allele

Choi, Jee‐Hye; Min, Na Young; Lkhagvasuren, Gavaachimed; Ko, Young Jin; Han, Sung Hoon; Kim, Kyung Yong; Kim, Kijung; Park, Ae Ja

doi:10.3892/mmr.2014.2639

Cited by 4 publications

(2 citation statements)

References 50 publications

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“…SNP −11377C/G (rs266729) demonstrated the prevalence of Korean T2D. 35 Our results have shown that adiponectin levels significantly declined in GDM with SNP −11377 C/G (rs266729) C allele. Nomani et al found that an elevated level of adiponectin was associated with the G allele of SNPs −11377 C/G (rs266729) in the Iran population.…”

Section: Discussionmentioning

confidence: 50%

The Variants in ADIPOQ are Associated with Maternal Circulating Adipokine Profile in Gestational Diabetes Mellitus

Tangjittipokin¹,

Narkdontri²,

Teerawattanapong³

et al. 2023

JMDH

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Background Gestational diabetes mellitus (GDM) is the most common association with hyperglycemia and glucose intolerance during pregnancy. The adipokines play an important to control insulin secretion and glucose. This study aimed to investigate the association between maternal circulating adipokine levels and ADIPOQ gene polymorphism among pregnant women subjects with GDM and normal glucose tolerance (NGT). Methods Participants including 229 normal pregnant women and 197 GDM pregnant women were enrolled from 2015 to 2018 at Siriraj hospital. Serum adipokine levels including adiponectin, adipsin/factor D, NGAL/Lipocalin-2, total PAI-1, and resistin were measured by immunoassay. ADIPOQ variations were investigated including −11377C/G (rs266729), +45T/G (rs2241766), and +276G/T (rs1501299). Results Serum adiponectin concentration was also significantly decreased among the GDM who had aged less than 35 years old whereas adipsin levels were significantly lower among the GDM who had aged more than 35 years old. Also, adiponectin and total PAI-1 levels were significantly lower among the GDM who had a BMI of less than 30 kg/m 2 . The G allele frequency of ADIPOQ +45T/G was significantly different between GDM and controls (p = 0.03). ADIPOQ +45T/G was associated with an increased risk of GDM (odds ratio [OR]: 1.554; 95% confidence interval [CI]: 1.010–2.390; p =0.045). The −11377C/G was affected by the level of adiponectin (p = 0.04). The C allele of −11377C/G SNP declined serum adiponectin levels and may be a risk factor for GDM. Conclusion This study revealed that genetics play important roles in circulating adipokines among pregnant women. ADIPOQ polymorphisms had significant associations with adiponectin levels in GDM patients.

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Section: Discussionmentioning

confidence: 50%

The Variants in ADIPOQ are Associated with Maternal Circulating Adipokine Profile in Gestational Diabetes Mellitus

Tangjittipokin¹,

Narkdontri²,

Teerawattanapong³

et al. 2023

JMDH

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“…It has been reported that −11377 G allele might be a risk factor for type 2 diabetes among white individuals. Choi et al reported that the −11377 G allele might be responsible for T2DM incidence among Korean population . In contrast, AlSaleh et al failed to demonstrate such an association in South Asian, Southeast Asian, Black, Middle Eastern, and Far Eastern populations.…”

Section: Discussionmentioning

confidence: 98%

Association between the −11377 C/G and −11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile

Nomani

Hesami

Vaisi-Raygani

et al. 2018

J of Cellular Biochemistry

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Adipose tissue, an endocrine organ, secretes bioactive factors including adiponectin. Adiponectin is a protein hormone that enhances insulin sensitivity through increased fatty acid oxidation and inhibition of hepatic glucose production. We assessed the association of the adiponectin promoter region polymorphisms -11391 G/A and -11377 C/G with susceptibility to type 1 (T1DM) and type 2 (T2DM) diabetes mellitus in the population of west Iran. Also, we investigated the effect of adiponectin level and lipid profile on T1DM and T2DM development. In this case-control study, we recruited 189 patients with diabetes (100 T2DM and 89 T1DM) and 161 sex and age-matched unrelated healthy controls. Adiponectin mutations were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the protein level was measured by the enzyme-linked immunosorbent assay. Other biochemical parameters were determined by routine laboratory methods. The G allele of adiponectin gene at -11377 position (C/G) significantly increased the risk of T1DM. With respect to genotype models, codominant (2.97 times), dominant (3.6-fold), and over-codominant (2.9-fold) patients with T1DM who carried -11377 C > G single-nucleotide polymorphisms were significantly susceptible to the development of the disease. A significantly higher level of adiponectin in T1DM was oberved compared with the control group. In contrast, patients with T2DM had lower adiponectin levels compared with healthy controls. The genotype distributions of -11391 G/A polymorphisms were the same for patients with diabetes and control groups. The presence of G allele at -11377 C/G adiponectin gene significantly increased serum adiponectin level and may be a risk factor for T1DM susceptibility among the western Iranian population.

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Association study between adiponectin gene variants, serum levels and the risk of type 2 diabetes in Tunisian women: Insights from BMI stratification

Sarray,

Ezzidi,

Moussa

et al. 2024

Cytokine

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Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated -11,377 G adiponectin allele

Cited by 4 publications

References 50 publications

The Variants in ADIPOQ are Associated with Maternal Circulating Adipokine Profile in Gestational Diabetes Mellitus

The Variants in ADIPOQ are Associated with Maternal Circulating Adipokine Profile in Gestational Diabetes Mellitus

Association between the −11377 C/G and −11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile

Association study between adiponectin gene variants, serum levels and the risk of type 2 diabetes in Tunisian women: Insights from BMI stratification

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