Dual Inhibition of Wound Healing and Oxidative Process by Montelukast in Experimental Colon Anastomoses

Canbay, Emel; Ağaçhan, Bedia; Öztürk, Tülin; Giriş, Murat; Asoğlu, Oktar; Balık, Emre; Buğra, Dursun

doi:10.1177/1553350610376393

Cited by 16 publications

(12 citation statements)

References 28 publications

(29 reference statements)

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“…Montelukast, one of the selective reversible CysLT 1 receptor antagonist, is used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies [34]. It is reported that montelukast can reduce eosinophilic inflammation in the airways [35–37].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Köse

Sapmaz

Sarihan

et al. 2012

The Scientific World Journal

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The effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Köse

Sapmaz

Sarihan

et al. 2012

The Scientific World Journal

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“…33 It is reported that montelukast can reduce eosinophilic inflammation in the airways. [34][35][36] Besides, CysLT1 receptor antagonists or biosynthesis inhibitors ameliorate ethanol-induced gastric mucosal damage, 37,38 experimental colitis, 39 and wound healing.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

et al. 2012

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Objective: In this study, the therapeutic and protective effects of montelukast against cisplatin (CP)-induced acute renal damage were investigated. Materials and Methods: Thirty-five female rats were divided into five groups as follows: (1) control, (2) montelukast (10 mg/kg daily for 10 days per-oral (p.o.), (3) CP (single dose 7 mg/kg intraperitoneally (i.p.)), (4) CP + montelukast (10 mg/kg daily for 10 days p.o., after 3 days of the injection of CP), (5) montelukast (10 mg/kg daily for 10 days p.o.) + CP (single dose 7 mg/kg i.p., after the last dose of montelukast). At the end of the experiment, malondialdehyde (MDA), a lipid peroxidation product, myeloperoxidase (MPO), and reduced glutathione (GSH) levels were determined in the renal tissue. Also, blood urea nitrogen (BUN) and creatinine (Cr) levels were assayed from the trunk blood samples. Results: CP treatment caused a significant elevation of MDA, MPO, BUN, and Cr levels when compared with the control group. Also, GSH levels were found to be reduced due to the CP treatment. Montelukast administration after CP injection ameliorated all of these parameters. Our histopathological findings (marked swelling of epithelial cells, tubular dilatation, tubular desquamation, and loss of brush border in the kidney) were consistent with the biochemical results. Conclusion: Montelukast treatment after CP injection exerted therapeutic effects against CP-induced acute kidney damage.

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“…Therefore, oral treatment of ML has effect on the maintenance treatment of asthma and relieve symptoms of seasonal allergies in adults and children 8 . Several studies also showed that ML has a significant antioxidative effect on inhibition of lipid peroxidation in some tissues such as testis and liver 9,10 .…”

Section: Montelukast (Ml) Is An Anti-inflammatory Drugmentioning

confidence: 99%

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

et al. 2016

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PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.

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Dual Inhibition of Wound Healing and Oxidative Process by Montelukast in Experimental Colon Anastomoses

Abstract: ML causes impairment of wound healing without altering the anastomosis bursting pressure and reverses the oxidative damage of the colon anastomoses in rats.

Cited by 16 publications

References 28 publications

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

Beneficial Effects of Montelukast against Cisplatin-Induced Acute Renal Damage in Rats

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

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