Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by Molecular Field Topology Analysis

Butrylacetycholinesterase Activity in Liver and Plasma, Liver Glycogen and Plasma Glucose Content, Haematology and Behaviour of Clariid Catfish Clarias Gariepinus to Dichlorvos

“…Although previous studies have shown a positive correlation between BuChE activity and glucose levels (Cwiertnia et al, 2010;Jabeen et al, 2014) this study showed significant correlation (P <0.05) with liver glycogen. Although the mechanism is unknown, evidence of relationship between the activity of BuChE and carbohydrate metabolism in liver and plasma of C. gariepinus could serve as early warning of health disorder (Thiermann et al, 2007;Cwiertnia et al, 2010;Benyamin et al, 2011;Santarpia et al, 2013).…”

1H and 13C NMR spectral assignments of novel flavonoids bearing benzothiazepine

“…The procedure used to assign the NMR data of derivative 8, [1,4]thiazepin-4-yl) naphthalen-1-ol was as follows: 28 carbon peaks were observed in the 13 C NMR spectrum. Of them, only one methylene peak at 36.1 ppm was observed in the DEPT experiments, which was the benzothiazepine-3 carbon (named C-bz3).…”

“…A variety of derivatives can be designed by modifying the positions of the double bond and benzene ring. 2,3-Dihydro-1,5-benzothiazepine (also known as 2,3-dihydro[b] [1,4]thiazepine) derivatives show diverse biological activities, including inhibitory effects on alpha-glucosidase, urease, cholinesterase, and butyrylcholinesterase, and agonistic activity toward the transient receptor potential ankyrin 1 (TRPA1) receptor ( Fig. 1(A)).…”

“…1(A)). [1][2][3][4] When two benzene rings are attached at the C-2 and C-4 positions, 2,4-diphenyl-2,3-dihydro-1,5-benzothiazepine containing a C6-C3-C6 skeleton can be derived ( Fig. 1(B)).…”

Pyridine sulfonamide as a small key organic molecule for the potential treatment of type-II diabetes mellitus and Alzheimer’s disease: In vitro studies against yeast α-glucosidase, acetylcholinesterase and butyrylcholinesterase

“…The high desire and need for the development of potent dual inhibitors for the treatment of both AD and DM [12,27], and our continued research efforts for the synthesis and evaluation of AChE, BChE and α-glucosidase inhibitors [22][23][24][25][26]. In this paper, we report the synthesis of a series of new pyridine sulfonamide derivatives and their in vitro AChE, BChE and α-glucosidase inhibition activities and in silico molecular modeling studies to uncover the binding patterns of these compounds with respective targeted proteins.…”