Dual-gated cardiac PET–Clinical feasibility study

Teräs, Mika; Kokki, Tommi; Durand-Schaefer, Nicolas; Noponen, Tommi; Pietilä, Mikko; Kišš, Ján; Hoppela, Erika; Sipilä, Hannu; Knuuti, Juhani

doi:10.1007/s00259-009-1252-4

Cited by 62 publications

(55 citation statements)

References 14 publications

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“…Lowdose or ultra-low-dose CT (46,47), as well as slow CT (48,49) and ultra-fast CT, have been tried to match the image resolution to that of the MPI in an attempt to improve registration of the MPI and CT images, but with no distinct advantages. Dual gated PET/CT with ECG gating and gating for respiratory motion are feasible and are being tested (50)(51)(52). Some of the newer-generation fast SPECT scanners have low-dose CT-based attenuation correction (53).…”

Section: Attenuation-correction Ct Scan (Ctac)mentioning

confidence: 99%

SNMMI/ASNC/SCCT Guideline for Cardiac SPECT/CT and PET/CT 1.0

et al. 2013

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Section: Attenuation-correction Ct Scan (Ctac)mentioning

confidence: 99%

SNMMI/ASNC/SCCT Guideline for Cardiac SPECT/CT and PET/CT 1.0

et al. 2013

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“…As the spatial resolution of clinical PET scanners improves, losses of image quality due to motion become a major limitation of the diagnostic accuracy of clinical cardiac 1,2 and oncology PET studies. [3][4][5] Respiratory gating [6][7][8] is sometimes used to reduce motion blurring in thoracic clinical PET imaging.…”

Section: Introductionmentioning

confidence: 99%

Nonrigid PET motion compensation in the lower abdomen using simultaneous tagged-MRI and PET imaging

et al. 2011

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Purpose: We propose a novel approach for PET respiratory motion correction using tagged-MRI and simultaneous PET-MRI acquisitions. Methods: We use a tagged-MRI acquisition followed by motion tracking in the phase domain to estimate the nonrigid deformation of biological tissues during breathing. In order to accurately estimate motion even in the presence of noise and susceptibility artifacts, we regularize the traditional HARP tracking strategy using a quadratic roughness penalty on neighboring displacement vectors (R-HARP). We then incorporate the motion fields estimated with R-HARP in the system matrix of an MLEM PET reconstruction algorithm formulated both for sinogram and list-mode data representations. This approach allows reconstruction of all detected coincidences in a single image while modeling the effect of motion both in the emission and the attenuation maps. At present, tagged-MRI does not allow estimation of motion in the lungs and our approach is therefore limited to motion correction in soft tissues. Since it is difficult to assess the accuracy of motion correction approaches in vivo, we evaluated the proposed approach in numerical simulations of simultaneous PET-MRI acquisitions using the NCAT phantom. We also assessed its practical feasibility in PET-MRI acquisitions of a small deformable phantom that mimics the complex deformation pattern of a lung that we imaged on a combined PET-MRI brain scanner. Results: Simulations showed that the R-HARP tracking strategy accurately estimated realistic respiratory motion fields for different levels of noise in the tagged-MRI simulation. In simulations of tumors exhibiting increased uptake, contrast estimation was 20% more accurate with motion correction than without. Signal-to-noise ratio (SNR) was more than 100% greater when performing motion-corrected reconstruction which included all counts, compared to when reconstructing only coincidences detected in the first of eight gated frames. These results were confirmed in our proofof-principle PET-MRI acquisitions, indicating that our motion correction strategy is accurate, practically feasible, and is therefore ready to be tested in vivo. Conclusions: This work shows that PET motion correction using motion fields measured with tagged-MRI in simultaneous PET-MRI acquisitions can be made practical for clinical application and that doing so has the potential to remove motion blur in whole-body PET studies of the torso.

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“…Nevertheless, dual respiratory/cardiac gating has been shown to allow better resolution of the myocardial walls as compared with ungated acquisition. 4 Generally speaking, the trade-off between image noise and gating has to be carefully considered, 17 and due to practical difficulties, respiratory motion of the heart during the cardiac cycle is typically neglected in the cardiac PET practice.…”

Section: Respiratory-gated Petmentioning

confidence: 99%