Dual-functioning IQ-LVs as lysosomal viscosity probes with red-shifted emission and inhibitors of autophagic flux

Park, Jaehyun; Lim, Bumhee; Lee, Na Keum; Lee, Ji Hye; Jang, Kyungkuk; Kang, San Won; Kim, Suzi; Kim, Ikyon; Hwang, Hyonseok; Lee, Jeeyeon

doi:10.1016/j.snb.2020.127764

Cited by 36 publications

(8 citation statements)

References 59 publications

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“…To detect analytes, compared with other outdated analysis technologies, there has been widespread use of the fluorescence imaging method due to excellent selectivity, high sensitivity, real-time imaging, and simple operation. [20][21][22][23][24][25] Many reasonably designed fluorescent probes for individual detec-tion of cysteine [26][27][28][29][30][31][32][33][34][35] or viscosity [36][37][38][39][40] have been manufactured in recent years, but there is currently no method for the detection of cysteine in viscous living systems. Thus, we developed a dual-functional probe for detecting and imaging cysteine and viscosity to discover their inherent relationship in living systems and treat various diseases (Table S2 †).…”

Section: Introductionmentioning

confidence: 99%

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

et al. 2023

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Section: Introductionmentioning

confidence: 99%

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

et al. 2023

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“…Due to a high demand for the development of novel fluorescent core skeletons, considerable progress has been made over the past few decades, which has resulted in the synthesis of various new fluorophores characterized by specific photophysical properties allowing the development of novel fluorescent probes [ 9 , 10 , 11 , 12 , 13 ]. As an example, indolizine-based organic molecules were successfully exploited in new fluorophores and fluorescent probes [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Synthetic methods for various types of indolizine scaffolds have led to the development of well-defined fluorophore scaffolds with an in-depth studied structure-fluorescence relationship.…”

Section: Introductionmentioning

confidence: 99%

Color-Tunable Indolizine-Based Fluorophores and Fluorescent pH Sensor

Kim

2021

Molecules

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A new fluorescent indolizine-based scaffold was developed using a straightforward synthetic scheme starting from a pyrrole ring. In this fluorescent system, an N,N-dimethylamino group in the aryl ring at the C-3 position of indolizine acted as an electron donor and played a crucial role in inducing a red shift in the emission wavelength based on the ICT process. Moreover, various electron-withdrawing groups, such as acetyl and aldehyde, were introduced at the C-7 position of indolizine, to tune and promote the red shift of the emission wavelength, resulting in a color range from blue to orange (462–580 nm). Furthermore, the ICT effect in indolizine fluorophores allowed the design and development of new fluorescent pH sensors of great potential in the field of fluorescence bioimaging and sensors.

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“…As an attractive analytical method, the fluorescence technique is advantageous over traditional methods toward viscosity sensing, due to its simple preparation procedure, highly visualized results, noninvasiveness, requirement of less sample, etc. − To date, several kinds of molecular rotors have been developed for viscosity sensing, such as mitochondrial viscosity tracking, − lipid droplet viscosity determination, , lysosomal viscosity investigation, − and so on. In fact, most of the reported rotors have been explored in the biological system; several representative rotors have been collected in Table S1.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Viscosity Detection in Beverages with an Aggregation-Induced Emission-Based Molecular Rotor

Zou

Zeng

et al. 2021

ACS Food Sci. Technol.

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Noninvasive and effective viscosity inspection during the deterioration process is expected to ease the burden of foodborne illnesses, since viscosity is closely related to spoilage extent. In this study, a novel molecular rotor, DPMBEQ, was developed to monitor the beverage microenvironmental viscosity alterations to achieve food safety inspection. This rotor comprised the typical triphenylamine donor and quinolinium acceptor and displayed aggregation-induced emission features, with a large Stokes shift of 184 nm in glycerol. DPMBEQ possesses a highly sensitive response toward viscosity change and features with good photostability and high selectivity in complex media. With the assistance of the fluorescent analytical technique, DPMBEQ achieved identifying the thickening effect of food gum. More importantly, DPMBEQ was explored to visualize viscosity variations during the beverage deterioration process. We expect that our trial can facilitate the continued perfection of food analytical methods toward food quality and safety inspection.

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Dual-functioning IQ-LVs as lysosomal viscosity probes with red-shifted emission and inhibitors of autophagic flux

Cited by 36 publications

References 59 publications

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

A ‘double locked’ ratiometric fluorescent probe for detection of cysteine in a viscous system and its application in cancer cells

Color-Tunable Indolizine-Based Fluorophores and Fluorescent pH Sensor

Noninvasive Viscosity Detection in Beverages with an Aggregation-Induced Emission-Based Molecular Rotor

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