Dual-functional ultrathin wearable 3D particle-in-cavity SF-AAO-Au SERS sensors for effective sweat glucose and lab-on-glove pesticide detection

Wang, Dan; Xu, Guogang; Zhang, Xingshuang; Gong, Hongyu; Jiang, Li Jun; Sun, Guanliang; Liu, Yu; Liu, Guoran; Li, Yong; Yang, Shikuan; Liang, Xiu

doi:10.1016/j.snb.2022.131512

Cited by 56 publications

(40 citation statements)

References 55 publications

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“…( Mohamad Yunos and Nordin, 2020 ). This did not stop researches for monitoring sweat glucose: we report wearable skin pads based on colorimetric fluorescent probes, a new user-friendly electrochemical sensor that however needs personalized precalibration; a self-powered smartwatch; and the already cited SERS-based wearable sensors ( Zhao et al, 2019 ; Cui et al, 2020 ; Wang Y. et al, 2021 , 2022 ; Sempionatto et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

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Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Todaro

Begarani²,

Sartori³

et al. 2022

Front. Chem.

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Diabetes has no well-established cure; thus, its management is critical for avoiding severe health complications involving multiple organs. This requires frequent glycaemia monitoring, and the gold standards for this are fingerstick tests. During the last decades, several blood-withdrawal-free platforms have been being studied to replace this test and to improve significantly the quality of life of people with diabetes (PWD). Devices estimating glycaemia level targeting blood or biofluids such as tears, saliva, breath and sweat, are gaining attention; however, most are not reliable, user-friendly and/or cheap. Given the complexity of the topic and the rise of diabetes, a careful analysis is essential to track scientific and industrial progresses in developing diabetes management systems. Here, we summarize the emerging blood glucose level (BGL) measurement methods and report some examples of devices which have been under development in the last decades, discussing the reasons for them not reaching the market or not being really non-invasive and continuous. After discussing more in depth the history of Raman spectroscopy-based researches and devices for BGL measurements, we will examine if this technique could have the potential for the development of a user-friendly, miniaturized, non-invasive and continuous blood glucose-monitoring device, which can operate reliably, without inter-patient variability, over sustained periods.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, subcutaneous injection of metal materials can produce toxicity, appropriate microneedles are costly and can easily cause permanent skin damages, and in any case in-vivo efficacy has been not completely demonstrated. ( Asharani et al, 2008 ; Ma et al, 2011 ; Moore et al, 2018 ; Wang et al, 2022 ).…”

Section: Blood Glucose Monitoring Devicesmentioning

confidence: 99%

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Todaro

Begarani²,

Sartori³

et al. 2022

Front. Chem.

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“…Since sweat samples containing different drugs exhibit completely Frontiers in Chemistry frontiersin.org different SERS spectra, the sensor can fingerprint the targets extracted from sweat, monitor changes in trace amounts of drugs in the body through sweat, and obtain an individual drug metabolism profile. Wang et al (2022) designed a bifunctional ultra-thin flexible PIC array structure-based SF-AAO-Au wearable SERS sensor with good skin adhesion, excellent mechanical flexibility, and SERS activity is not limited by any natural skin deformation (Figure 2B). The developed SF-AAO-Au SERS sensor shows Frontiers in Chemistry frontiersin.org excellent glucose recognition in the concentration range of 100-10 6 nM with LOD down to 168 nM enabling nondestructive, painless and rapid qualitative detection of ultra-trace low concentrations of sweat glucose on real human skin surfaces.…”

Section: Applications In Point-of-care Testing Non-invasive Medical D...mentioning

confidence: 99%

“…To achieve high SERS sensitivity and uniformity, Wang et al created a wearable SERS ultra-thin and flexible multi-functional sensor (SF-AAO-Au) based on a micro-nano array of cavity particle structure of silk fibroin, anodic aluminum oxide (AAO) and gold nanoparticles. The high SERS sensitivity and uniformity are due to the efficient enhancement ability of porous 3D PIC structure and highly ordered periodic array ( Liu, et al, 2022 ; Wang, et al, 2022 ). As illustrated in Figure 1E , Li et al (2022) designed a quasi-periodic PIC Raman substrate structure based on silver nanoparticles and anodic alumina templates to achieve sensitive detection at the single-molecule level and further improved the detection accuracy by introducing molybdenum disulfide as an internal standard.…”

Section: Wearable Surface-enhanced Raman Scattering Sensors：design An...mentioning

confidence: 99%

Surface-enhanced Raman scattering as a potential strategy for wearable flexible sensing and point-of-care testing non-invasive medical diagnosis

Liu

Guo

et al. 2022

Front. Chem.

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As a powerful and effective analytical tool, surface-enhanced Raman scattering (SERS) has attracted considerable research interest in the fields of wearable flexible sensing and non-invasive point-of-care testing (POCT) medical diagnosis. In this mini-review, we briefly summarize the design strategy, the development progress of wearable SERS sensors and its applications in this field. We present SERS substrate analysis of material design requirements for wearable sensors and highlight the benefits of novel plasmonic particle-in-cavity (PIC)-based nanostructures for flexible SERS sensors, as well as the unique interfacial adhesion effect and excellent mechanical properties of natural silk fibroin (SF) derived from natural cocoons, indicating promising futures for applications in the field of flexible electronic, optical, and electrical sensors. Additionally, SERS wearable sensors have shown great potential in the fields of different disease markers as well as in the diagnosis testing for COVID-19. Finally, the current challenges in this field are pointed out, as well as the promising prospects of combining SERS wearable sensors with other portable health monitoring systems for POCT medical diagnosis in the future.

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“…However, the Raman scattering effect is generally 10 10 –10 14 times lower than infrared and fluorescent signals, making the Raman scattering effect not applicable for the recognition of contaminants at low concentrations [ 125 , 126 , 127 ]. Scientists discovered that when the analyzed samples are located in close proximity or adsorbed to a nanostructured metal (such as gold and silver), the incident light passing through the sample produces a massive intensification of Raman scattering, also known as SERS [ 128 , 129 , 130 ]. The controllable number and location of plasmonic nanoparticles on the SERS platform allows the high reproducibility and sensitivity of detection compared to the free-assemble nanoparticle [ 131 , 132 ].…”

Section: Nanotechnology In Food Monitoringmentioning

confidence: 99%

Recent Progress in Nanotechnology-Based Approaches for Food Monitoring

et al. 2022

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Throughout the food supply chain, including production, storage, and distribution, food can be contaminated by harmful chemicals and microorganisms, resulting in a severe threat to human health. In recent years, the rapid advancement and development of nanotechnology proposed revolutionary solutions to solve several problems in scientific and industrial areas, including food monitoring. Nanotechnology can be incorporated into chemical and biological sensors to improve analytical performance, such as response time, sensitivity, selectivity, reliability, and accuracy. Based on the characteristics of the contaminants and the detection methods, nanotechnology can be applied in different ways in order to improve conventional techniques. Nanomaterials such as nanoparticles, nanorods, nanosheets, nanocomposites, nanotubes, and nanowires provide various functions for the immobilization and labeling of contaminants in electrochemical and optical detection. This review summarizes the recent advances in nanotechnology for detecting chemical and biological contaminations in the food supply chain.

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Dual-functional ultrathin wearable 3D particle-in-cavity SF-AAO-Au SERS sensors for effective sweat glucose and lab-on-glove pesticide detection

Cited by 56 publications

References 55 publications

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Surface-enhanced Raman scattering as a potential strategy for wearable flexible sensing and point-of-care testing non-invasive medical diagnosis

Recent Progress in Nanotechnology-Based Approaches for Food Monitoring

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