Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

“…Additional modifications of the HELP constructs with small targeting amino acidic sequences (analogous to those reported for other nanomedicine platforms [17]) would help drug targeting and controlled release by increasing vector selectivity to specific anatomic and intracellular compartments. Improvements could be pursued by embedding bioactive domains directly in the polypeptide primary structure through the recombinant DNA approach in order to obtain biologically functional systems that can actively interact with the cells and tissues of interest.…”

Section: Expert Opinionmentioning

confidence: 99%

The potential of recombinant human elastin-like polypeptides for drug delivery

Ciofani¹,

Genchi²,

Mattoli³

et al. 2014

Expert Opinion on Drug Delivery

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Mimicking the structure of natural proteins by recombinant biopolymers is a useful approach for the development of novel bioactive biomaterials with desired properties, that help elucidate molecular interactions in biological systems and elaborate strategies for tissue engineering and drug delivery purposes. Structurally based on elastin repeated motifs, recombinant human elastin-like polypeptides (HELPs) represent excellent examples of bio-inspired polymers proposed for tissue engineering, and recently exploited also for drug delivery applications. This Editorial reports on the latest advances in the research on HELP biopolymers for drug delivery and targeting applications. The main findings will be summarized with emphasis on the ‘smart’ properties of HELPs, which render this class of biopolymers particularly interesting in the whole biomedicine field. Considerations about further improvements of the current HELP-based systems will be provided, and a demonstration of the huge potential of HELPs in becoming leading material for drug delivery will be attempted

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“…Silver nanoparticles are being used in the field of electronics [7], and targeted drug delivery system [8]. In the diagnosis treatment of gloma and stroke [9], Stain resistant clothing [10], larvicidal and bactericidal [11] on cancer therapeutics [12] and cosmeceuticals [13]. As a result of its distinctive physico chemical properties wide applications of silver nanoparticles and its effect on the biological systems is of great concern.…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicology of Green Synthesized Silver Nanoparticles on Fresh Water Fish Mystus Gulio

Abirami

Jose

Govindarajulu

et al. 2017

Int J Pharm Pharm Sci

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Objective: Nanotechnology an advanced tool to synthesis atomic level particles. Increased application of silver nanoparticles results in the bioaccumulation of these particles in the environment. The biological effect of the green synthesized silver nanoparticles on the fresh water cat fish ws studied in the present study.Methods: Asystasia gangetica leaf extract was used to synthesize silver nanoparticles, the particles were characterized by scanning electron microscopy. Fifteen days after the introduction of fishes into the medium containing AgNPs, the fishes were sacrificed and the tissues were processed for biochemical and histological studies. Na + -K + Results:The results observed in the present study reveals a marked difference in the level of carbohydrate in the muscle tissue from 48.338±0.320 to 22.747±1.837 µg/100 mg wet tissue followed by gills and liver with 41.21% and 25.48% decrease. Total protein content was decreased from 649.094±1.429 to 491.56±0.925 µg/mg wet tissues. The drastic increase in the total lipids was observed in liver tissue of treated fishes from 0.240±0.004 to 0.408±0.005 mg/gm wet tissue. Na -ATPase was estimated using LeBel method. Estimation of carbohydrate was done by the Phenol-sulphuric acid method. Total protein was estimated using Lowry's method, Sulpho-Vanilline method was used to estimate the total lipids. + -K + Conclusion:The plant-mediated synthesized AgNPs shows a potential toxic effect on all the tissues studied; changes were observed in the normal architecture of tissues as well as in the biochemical parameters. To understand the mechanism of toxicity of these particles further studies at the molecular level has to be carried out.-ATPase activity of liver tissue increased from 0.153±0.001 to 0.225±0.003 in the liver tissue of treated fishes, followed by muscles and gills with 33.61% and 35% of the increase in the activity. Marked changes in the structure of gills with degenerated primary gill lamellae, necrosis, hyperplasia and fused primary lamellae were evident in experimental group. Necrosis, vacuolization, disintegrated nucleus and blood sinusoids were observed in liver tissues. Disintegration of myofibrils was evident in AgNP treated group of fishes.

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Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

Cited by 211 publications

References 40 publications

Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery

Functionalized nanocarrier combined seizure-specific vector with P-glycoprotein modulation property for antiepileptic drug delivery

The potential of recombinant human elastin-like polypeptides for drug delivery

Ecotoxicology of Green Synthesized Silver Nanoparticles on Fresh Water Fish Mystus Gulio

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