Dual fluorescence nano-conjugates based on gold nanoclusters for tumor-targeting imaging

Dual fluorescence nanoconjugates for ratiometric detection of reactive oxygen species in inflammatory cells

“…The AuNCs were synthesized according to a literature previously reported . Briefly, a fresh 3.0 mL histidine aqueous solution (3.2%, w/w) was added into 1.0 mL HAuCl 4 aqueous solution (24.3 mM), followed by rapid addition of 3.5 mL of NaH 2 PO 4 solution (1.2%, w/w), and the final pH value was adjusted to 5.0 with HCl.…”

“…The fluorescence emission spectra of AuNCs, QDs and AuNC‐QD were measured on a LS55 fluorescence spectrometer (Perkin Elmer) with an excitation wavelength of 360 nm, respectively. Room‐temperature photoluminescence QYs of QDs and AuNCs in water were determined by further following the previously reported method .…”

“…Gold nanoclusters (AuNCs), which consist of a few gold atoms, were also revealed to possess favorable fluorescence with strong intensity and robust resistance to photobleaching . Reliable fluorescence, low cytotoxicity along with biocompatibility made AuNCs to be a promising candidate for biomedical applications .…”

“…Reliable fluorescence, low cytotoxicity along with biocompatibility made AuNCs to be a promising candidate for biomedical applications . Our previous results reported that AuNCs stabilized by histidine showed a steady fluorescence . Fabrication of monodisperse nanoparticles assembled from discrete domains of different nanomaterials could avoid tedious modification processes by making complete use of the inherent active groups on the surface of the nanoparticles, which largely decreased the cost and time .…”

Recent Progress on Gold-Nanocluster-Based Fluorescent Probe for Environmental Analysis and Biological Sensing

“…They demonstrated the outstanding tumor-targeting capability of Au–cRGD–MPA for tumor cells through cell affinity investigations and elucidated the biodistribution characteristics and tumor-targeting ability of the probes in tumor-bearing mice and normal nude mice, respectively. Finally, for the effect of small size (less than 5 nm), most nanoconjugates are metabolized from living subjects via the kidney-bladder route and are therefore not harmful to organisms [90]. Yin et al developed a gold nanoparticle probe-based assay (GNPA) for ultrasensitive detection of the hepatitis C virus (HCV) core antigen [91].…”