Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Herrmann, F; Lochner, Adriane; Enders, B.; Komischke, B.; Rühl, H.

doi:10.1159/000206913

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…The reactivity of CLL samples with mAb Leu 1 or allied mAbs with similar specificity has been reported in earlier papers (16)(17)(18)(19)(20)(21)(22). Most, but not all of the these samples, reacted with such T-cell reagents.…”

Section: Discussionsupporting

confidence: 77%

p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

Herrmann

Komischke

et al. 1984

Scandinavian Journal of Haematology

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Lymphomatous cell samples from 86 patients with B-cell neoplasia (34 chronic lymphocytic leukaemia, 8 hairy-cell leukaemia, 5 prolymphocytic leukaemia, 20 immunocytic lymphoma, 9 centrocytic lymphoma, 3 centroblastic/centrocytic lymphoma, 3 lymphoblastic lymphoma, 1 plasma cell leukaemia and 3 plasmacytoma) were studied using the monoclonal antibody Leu 1, detecting a p69,71 antigen complex present on nearly all thymocytes, most (> 85 %) peripheral T-lymphocytes as well as some malignant B-cells. Furthermore, we compared the reactivity of Leu 1-positive B-cells with those exhibiting conventional surface markers such as mouse-erythrocyte-receptor, FcIgG-receptor, C3b-or C3d-receptor and surface immunoglobulins of the various heavy-and light-chain types. Our results demonstrate a correlation between the expression of p69,71 antigen complex and distinct phenotypes revealed by conventional markers and underline the value of Leu 1 monoclonal antibody in the differential diagnosis of human B-cell neoplasia.

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Section: Discussionsupporting

confidence: 77%

p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

Herrmann

Komischke

et al. 1984

Scandinavian Journal of Haematology

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Rheumatological manifestations in inborn errors of immunity

et al. 2019

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Chronic Lymphocytic Leukemia B-Lymphocytes Forming SRBC-Rosettes not Due to an Anti-SRBC Activity of Monoclonal Surface Immunoglobulin

Herrmann

Kołecki

Sieber

et al. 1985

American Journal of Clinical Pathology

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A case of chronic lymphocytic leukemia is described in which large numbers of peripheral blood lymphocytes expressed immunoglobulin on their membrane and rosetted spontaneously with sheep red blood cells (SRBC) at 4 degrees C. They also showed weak staining with a heterologous antiserum against T-cells as well as with a monoclonal antibody (OKT11) with specificity for an epitope associated with the SRBC-receptor, but failed to react with other T-lineage-restricted monoclonal antibodies. The B-cell origin of the leukemic cells was documented by the presence of light-chain-restricted monoclonal surface immunoglobulin, reactivity with various monoclonal anti-B-cell reagents, presence of Ia-like antigens, their capability to synthesize intracytoplasmic immunoglobulin on exposure to phorbol ester TPA, their lack of response to T-cell mitogen PHA, and their inability to help or suppress the allogeneic B-cell response upon PWM stimulation. Extensive blocking studies with both specific antisera and Forsmann antigen-rich guinea pig kidney extracts, which did not prevent SRBC-rosetting, lend support to the hypothesis that SRBC-rosette formation in this case was not attributable to an anti-SRBC affinity of the surface immunoglobulin on the cells. This case will be discussed in relation to the recent finding of SRBC-rosette expression on some cultured chronic lymphocytic leukemia B-lymphocytes.

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Dual Expression of T and B Cell Markers in Human B Cell Neoplasias

Cited by 4 publications

References 11 publications

p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

Rheumatological manifestations in inborn errors of immunity

Chronic Lymphocytic Leukemia B-Lymphocytes Forming SRBC-Rosettes not Due to an Anti-SRBC Activity of Monoclonal Surface Immunoglobulin

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