p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

Herrmann, F; Komischke, B.; Hj, Langermann; Wd, Ludwig; Sieber, G.; Rühl, H.

doi:10.1111/j.1600-0609.1984.tb02180.x

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Thus, it has been reported that neoplastic CLL cells may be recognized by polyclonal anti-T heteroantisera (10, 11) and may occasionally bear sheep erythrocyte receptors (12,13,14,15). Furthermore, it is well-established that the T1 (CD5) and TQl/Leu8 antigens are expressed on the great majority of CLL B-lymphocytes (16,17,18,19) and it is now generally thought that the normal counterpart of CLL may be a Tl+/SIg+ B-cell localized in the follicles of lymphoid tissues (20) and foetal spleen (21). The 65Kd glycoprotein (CDS) is therefore widely used as a specific and diagnostic marker for CLL.…”

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Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens

Morabito

Tassinari

Callea

et al. 1987

European J of Haematology

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In 7 cases of chronic B‐cell lymphoproliferative disorders – 6 chronic lymphocytic leukaemias and 1 non‐Hodgkin lymphoma in leukaemic phase – which co‐expressed T‐cell markers (CD3, CD2) the clonal origin was investigated at the DNA level. In accordance with the diagnosis, all cases showed a monoclonally rearranged configuration of the immunoglobulin genes. On the contrary, the T‐cell receptor beta chain gene always retained a germ‐line organization. These findings demonstrate that B‐cell chronic lymphoproliferative disorders which co‐express T‐cell‐related markers are truly composed of monoclonal B‐cell elements.

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Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens

Morabito

Tassinari

Callea

et al. 1987

European J of Haematology

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The simultaneous presentation of peripheral T-cell lymphoma and hairy cell leukemia

Lawlor

O’Briain

Finn

et al. 1987

Cancer

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A patient who presented simultaneously with B hairy cell leukemia (HCL) and peripheral T-cell lymphoma (ITL) is described. The diagnoses of the two neoplasms were made by standard morphologic and cytochemical study and confirmed immunologically. There was no evidence of overlap in markers to suggest that they arose from a single clone of malignant cells. It is suggested that the simultaneous occurrence of the two neoplasms in the same patient reflects an underlying predisposition to the development of neoplasia in HCL.Cancer 60:1537-1544, 1987.AIRY CELL LEUKEMIA (HCL) is a chronic lympho-H proliferative disorder characterized clinically by splenomegaly, pancytopenia and the presence of abnormal cells which usually show marked cytoplasmic projections, the so-called "hairy cells," and histologically confirmed by specific spleen and bone marrow appearances. The majority of cases of HCL have been shown to be of B-cell origin' although rare but well documented cases of HCL with hybrid T/B phenotypes or T-cell phenotypes have been Although data from a large series of cases of HCL is lacking, there is evidence that second neoplasms are common in HCL.' Second lymphoid malignancies reported with HCL include large cell lymphoma9.'' multiple myeloma,"-'3 and SCzary ~y n d r o m e ,~ and it has been tempting to postulate that in these cases both neoplasms arise from the same clone. Zucker-Franklin et a/.' described a case of T-HCL and Skzary syndrome where the hairy cells and SCzary cells had the same immunological phenotype and appeared to arise from the same clone. However, in two of three cases of multiple myeloma and HCL" it was found that both the heavy and light chain classes of the paraprotein were different from the immunoglobulins on the hairy cells suggesting that they were in fact from separate clones. Accepted for publication April 6, 1987.We have recently studied a patient who presented simultaneously with peripheral T-cell lymphoma (PTL)I4 and B-HCL. No evidence of overlap was found in tumor markers and the HCL and PTL appeared to represent the co-existence of two diseases either randomly or more likely as a result of an underlying predisposition to neoplasia in HCL. Case ReportA 65-year-old school teacher presented in May 1983 with a raised nontender 1.5 cm diameter lesion on her chin which had developed over 2 months. This was removed and reported histologically to be an undifferentiated carcinoma. In July 1983 a left parietal scalp lesion developed and after biopsy and review of the earlier specimen, a diagnosis of large cell lymphoma was made. She had no systemic complaints, no previous illness and no exposure to radiation. There was no hepatomegaly splenomegaly or lymphadenopathy.Hematologic investigations showed a hemoglobin (Hb) of 1 1.7 gm/dl, platelet count 97 X lo9 /I and leukocyte count 2.2 X 109/1: polymorphs 3 I%, lymphocytes 50%, eosinophils 4%, monocytes 1 %, hairy cells 8%, and atypical lymphocytes with convoluted nuclei 6% (Figs. 1A and IB). Occasional tartrate resistant acid phosphatase (TRAP...

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Circulating cerebriform lymphoid cells (sezary-type cells) in a b-cell malignant lymphoma

O’Briain

Lawlor

Sarsfield

et al. 1988

Cancer

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Circulating cerebriform lymphoid cells (Sezary cells) are considered to be highly predictive of cutaneous T-cell Lymphoma (CTCL). A leukemic peripheral blood (leukocyte count 24.5 x 10(9)/l) composed predominantly of cerebriform cells was found in a 75-year-old man presenting with weight loss and generalized lymphadenopathy but without skin lesions. Cell suspensions studies and immunohistochemistry of peripheral blood revealed that the cerebriform cells were B-cells (IgM+ Kappa+, HLA DR+, Leu 1+, CALLA-, B1+, and OKT 10+). A variety of T-cell markers (other than Leu1) was negative. Computer-assisted morphometry confirmed a nuclear profile typical of CTCL (mean nuclear contour index, 7.47). A lymph node that underwent subsequent biopsy revealed a follicular malignant lymphoma of small to intermediate cells with similar morphologic and immunologic characteristics to the circulating cerebriform cells. The findings of a leukemic presentation of a cerebriform B-cell lymphoma extends the recent observation of nodal B-cell lymphomas composed of cerebriform cells and indicates that circulating cerebriform cells should not be considered to be exclusively of T-cell origin.

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p69,71 Antigen Complex Detected by Monoclonal Antibody Leu 1 in the Identification of Particular Stages of Malignant B‐Cell Differentiation

Cited by 5 publications

References 21 publications

Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens

Germ‐line configuration of the T‐cell receptor beta‐chain gene in B‐cell chronic lymphoproliferative disorders which co‐express T‐cell antigens

The simultaneous presentation of peripheral T-cell lymphoma and hairy cell leukemia

Circulating cerebriform lymphoid cells (sezary-type cells) in a b-cell malignant lymphoma

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