Dual expression of CXCR4 and IL-35 enhances the therapeutic effects of BMSCs on TNBS-induced colitis in rats through expansion of Tregs and suppression of Th17 cells

Zhang, Nan; Fan, Heng; Tang, Qing; Zhang, Man; Xu, Meng; Chen, Qianyun; Liu, Yujin; Dong, Yalan; Wu, Hui; Deng, Shuangjiao

doi:10.1016/j.bbrc.2018.03.043

Cited by 25 publications

(41 citation statements)

References 30 publications

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“…In rats with TNBS-induced colitis, the migration capacity of these BM-MSCs to inflammatory colon was significantly increased. 63 And they demonstrated that CXCR4-IL-35-MSCs remarkably strengthened the immunomodulatory activity of BM-MSCs through the simultaneous suppression of Th17 cells and expansion of Tregs. Li et al 64 obtained similar results by upregulating intercellular adhesion molecule (ICAM)-1 in the mouse MSC cell line.…”

Section: Improves the Efficacy Of Mscsmentioning

confidence: 99%

“…In addition, Zheng et al 62 also found that azoxymethane (AOM) and DSS-induced colitis-associated tumorigenesis were significantly attenuated when CXCR4-upregulated BM-MSCs were administrated. Interestingly, Nan et al 63 used the same method to enhance the expression of CXCR4 and IL-35 in BM-MSCs simultaneously. In rats with TNBS-induced colitis, the migration capacity of these BM-MSCs to inflammatory colon was significantly increased.…”

Section: Improves the Efficacy Of Mscsmentioning

confidence: 99%

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Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

et al. 2020

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Inflammatory bowel diseases (IBD) are a group of chronic recurrent gastrointestinal inflammatory diseases, including ulcerative colitis (UC), Crohn's disease (CD) and IBD unclassified. The pathogenesis may be related to the mucosal immune dysfunction in genetically susceptible hosts affected by environmental factors. Current therapeutic agents mainly include aminosalicylates, corticosteroids, immunosuppressive drugs and novel biological agents. The purpose of treatment is to suppress inflammation and prevent irreversible structural damage. However, long‐term application of these drugs may lead to multiple adverse effects and is not always effective. Mesenchymal stem cells (MSCs) are multipotent progenitors with low immunogenicity, which can be obtained and expanded easily. They play an important role in regulating immune responses and repairing damaged tissues in vivo. Therefore, MSCs are considered to be a promising option for the treatment of IBD. Nonetheless, there are many factors that can reduce the efficacy of MSCs, such as gradual deterioration of functional stem cells with age, low recruitment and persistence in vivo and different routes of administration. In recent years, researchers have been able to improve the efficacy of MSCs by pretreatment, genetic modification or co‐application with other substances, as well as using different tissue‐derived cells, administration methods or doses. This article reviews these methods to provide references for more effective application of MSCs in the treatment of IBD in the future.

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Section: Improves the Efficacy Of Mscsmentioning

confidence: 99%

Section: Improves the Efficacy Of Mscsmentioning

confidence: 99%

Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

et al. 2020

View full text Add to dashboard Cite

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“…Mice model (157) Inflammatory bowel disease mouse model (143) Chemoinvasion assay (144) A mouse model of DR (140)…”

Section: T Cells Microgilamentioning

confidence: 99%

“…Focusing on the immunoregulation of MSCs, CXCR4 also plays a vital role in inflammatory diseases. Nan et al revealed that CXCR4 overexpression might reduce colon inflammation in rats while co-transfecting with IL-35 ( 143 ). On the one hand, MSCs with high-level CXCR4 have more robust immunomodulatory capacities by reducing the number of DCs and Th17 cells and increasing the number of M2-macrophages and Treg cells ( 143 ).…”

Section: Cell Surface Receptor-mediated Mscs Immunosuppressionmentioning

confidence: 99%

Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

Liu

Zhou

et al. 2020

Front. Immunol.

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In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for refractory inflammatory diseases and engineered MSCs have appeared on the market as therapeutic agents. Recently, engineered MSCs target to cell surface molecules on immune cells has been a new strategy to improve MSC applications. In this review, we discuss the roles of multiple receptors (ICAM-1, Gal-9, PD-L1, TIGIT, CD200, and CXCR4) in the process of MSCs' immunosuppressive properties. Furthermore, we discuss the principles and strategies for developing receptor-regulated MSCs and their mechanisms of action and the challenges of using MSCs as immunosuppressive therapies.

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“…26 A growing body of evidence has demonstrated that BMSC are non-immunogenic and, more importantly, display profound immunomodulatory and anti-inflammatory capabilities. [26][27][28][29][30] However, whether allogeneic BMSC may improve the microenvironment in periodontal lesion with immunomodulation is not clear.…”

Section: Introductionmentioning

confidence: 99%

The therapeutic role of bone marrow stem cell local injection in rat experimental periodontitis

Lü

Liu

Zhang

et al. 2019

J of Oral Rehabilitation

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Mesenchymal stem cell therapy brings hope for regenerating damaged periodontal tissues. The present study aimed to investigate the therapeutic role of local bone marrow stem cell (BMSC) injection in ligation-induced periodontitis and the underlying mechanisms. Alveolar bone lesion was induced by placing ligatures subgingivally around the bilateral maxillary second molars for 28 days. The alveolar bone lesion was confirmed by micro-CT analysis and bone histomorphometry. Allogeneic BMSC transplantation was carried out at 28 day after ligation. The survival state of the transplanted BMSC was observed by bioluminescent imaging. The implantation of the BMSC into the gingival tissues and periodontal ligament was confirmed by green fluorescent protein (GFP) immunohistochemical staining. The expression level of pro-inflammatory, tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and receptor activator of nuclear factor-κ B ligand (RANKL) and osteoprotegerin (OPG) in periodontal tissues were evaluated by immunohistochemical staining and real-time PCR. Significant reverse of alveolar bone lesion was observed after BMSC transplantation. The expression of TNF-α and IL-1β was down-regulated by BMSC transplantation. The number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts in the periodontal ligament was reduced, and the increased RANKL expression and decreased OPG expression were also reversed after BMSC transplantation. It is concluded that allogeneic BMSC local injection could inhibit the inflammation of the periodontitis tissue and promote periodontal tissue regeneration.

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Dual expression of CXCR4 and IL-35 enhances the therapeutic effects of BMSCs on TNBS-induced colitis in rats through expansion of Tregs and suppression of Th17 cells

Cited by 25 publications

References 30 publications

Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

The therapeutic role of bone marrow stem cell local injection in rat experimental periodontitis

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Dual expression of CXCR4 and IL-35 enhances the therapeutic effects of BMSCs on TNBS-induced colitis in rats through expansion of Tregs and suppression of Th17 cells

Cited by 25 publications

References 30 publications

Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

Potential methods for improving the efficacy of mesenchymal stem cells in the treatment of inflammatory bowel diseases

Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

The therapeutic role of bone marrow stem cell local injection in rat experimental periodontitis

Contact Info

Product

Resources

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Dual expression of CXCR4 and IL-35 enhances the therapeutic effects of BMSCs on TNBS-induced colitis in rats through expansion of Tregs and suppression of Th17 cells