Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner

Tse, J. S.; Dunmore‐Buyze, Joy; Drangova, Maria; Holdsworth, David W.

doi:10.1117/1.jmi.5.3.033503

Cited by 5 publications

(5 citation statements)

References 31 publications

(39 reference statements)

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“…The methods described were used for analyzing bone tissue samples. For this purpose, µCT data of bone tissue slices (n = 100) were used [27]. Micro / nanofocal X-ray inspection system for CT and 2D inspections of Phoenix V|tome|X S240 was used for scanning.…”

Section: Resultsmentioning

confidence: 99%

Automation of Bone Tissue Histology

et al. 2019

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In abstract methods of automation of histology, bone structure is considered. Possible inputs are snapshots from a microscope or computed tomography slices. An algorithm is proposed that differentiates objects according to their color (or grayscale) and recover morphology topology. An algorithm to separate morphological objects by their dimensions and color parameters was built. Measured parameters were bone surface, bone area, porosity, cortical thickness, canal number, canal area, and etc. Additionally, we measured the anisotropy properties of the bone tissue: distribution of porosity direction and degree of porosity elongation. A bone example was scanned by computed tomography. All data were measured by the proposed method and the results presented. An example algorithm of work on computed tomography data is shown in this work.

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Section: Resultsmentioning

confidence: 99%

Automation of Bone Tissue Histology

et al. 2019

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“…Although a dedicated DE-CBCT system for IGRT has not been commercially available, several implementations have been reported by performing two-scan approaches (Men et al 2015(Men et al , 2017, or developing novel single-scan methods (Shi et al 2020b, Jiang et al 2021, Ståhl et al 2021, Wang et al 2021. Most existing studies have focused on the impact of new algorithms or hardware modifications on image quality (Ren et al 2016, Tse et al 2018, Skaarup et al 2019, Cassetta et al 2020, Shi et al 2020a, Schröder et al 2022, However, less attention has been paid to the scanning protocols of DE-CBCT which are more complex than those for conventional CBCT due to the increased number of possible parameter combinations involving two energies. Therefore, the definition of image quality for DE-CBCT should be more comprehensive and include the accuracy of material decomposition, in addition to conventional metrics that describe anatomic visibility, such as contrast-to-noise ratio (CNR).…”

Section: Introductionmentioning

confidence: 99%

A generalizable new figure of merit for dose optimization in dual energy cone beam CT scanning protocols

Li,

Zhou,

Deng

et al. 2023

Phys. Med. Biol.

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Objective: This study proposes and evaluates a new figure of merit (FOMn) for dose¬ optimization of Dual-energy CBCT (DE-CBCT) scanning protocols based on size-dependent modeling of radiation dose and multi-scale image quality.Approach: FOMn was defined using Z-score normalization and was proportional to the dose efficiency providing better multi-scale image quality, including comprehensive contrast-to-noise ratio (CCNR) and electron density (CED) for CatPhan604 inserts of various materials. Acrylic annuluses were combined with CatPhan604 to create four phantom sizes (diameters of the long axis are 200 mm, 270 mm, 350 mm, and 380 mm, respectively). DE-CBCT was decomposed using image-domain iterative methods based on Varian kV-CBCT images acquired using 25 protocols (100 kVp and 140 kVp combined with 5 tube currents).Main results: The accuracy of CED was approximately 1% for all protocols, but degraded monotonically with the increased phantom sizes. Combinations of lower voltage + higher current and higher voltage + lower current were optimal protocols balancing CCNR and dose. The most dose-efficient protocols for CED and CCNR were inconsistent, underlining the necessity of including multi-scale image quality in the evaluation and optimization of DE-CBCT. Pediatric and adult anthropomorphic phantom tests confirmed dose-efficiency of FOMn-recommended protocols.Significance: FOMn is a comprehensive metric that collectively evaluates radiation dose and multi-scale image quality for DE-CBCT. The models and data can also serve as lookup tables, suggesting personalized dose-efficient protocols for specific clinical imaging purposes.

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“…The ideal position of the k-edges offers potential to increase contrast attenuation for single-energy micro-CT scans 33 and, more importantly, offers the opportunity to match the available x-ray spectrum and contrast agent in dual-energy micro-CT, which is used to distinguish contrast-enhanced vessels from inherently high-attenuating tissues (e.g. bone, calcifications) 35 .…”

Section: Introductionmentioning

confidence: 99%

PEG-modified gadolinium nanoparticles as contrast agents for in vivo micro-CT

Cruje

Dunmore-Buyze

Grolman

et al. 2021

Sci Rep

Self Cite

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Vascular research is largely performed in rodents with the goal of developing treatments for human disease. Micro-computed tomography (micro-CT) provides non-destructive three-dimensional imaging that can be used to study the vasculature of rodents. However, to distinguish vasculature from other soft tissues, long-circulating contrast agents are required. In this study, we demonstrated that poly(ethylene glycol) (PEG)-coated gadolinium nanoparticles can be used as a vascular contrast agent in micro-CT. The coated particles could be lyophilized and then redispersed in an aqueous solution to achieve 100 mg/mL of gadolinium. After an intravenous injection of the contrast agent into mice, micro-CT scans showed blood pool contrast enhancements of at least 200 HU for 30 min. Imaging and quantitative analysis of gadolinium in tissues showed the presence of contrast agent in clearance organs including the liver and spleen and very low amounts in other organs. In vitro cell culture experiments, subcutaneous injections, and analysis of mouse body weight suggested that the agents exhibited low toxicity. Histological analysis of tissues 5 days after injection of the contrast agent showed cytotoxicity in the spleen, but no abnormalities were observed in the liver, lungs, kidneys, and bladder.

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Dual-energy computed tomography using a gantry-based preclinical cone-beam microcomputed tomography scanner

Cited by 5 publications

References 31 publications

Automation of Bone Tissue Histology

Automation of Bone Tissue Histology

A generalizable new figure of merit for dose optimization in dual energy cone beam CT scanning protocols

PEG-modified gadolinium nanoparticles as contrast agents for in vivo micro-CT

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