Dual-Energy Computed Tomography

Parakh, Anushri; Macrì, Francesco; Sahani, Dushyant V.

doi:10.1016/j.rcl.2018.03.002

Cited by 40 publications

(12 citation statements)

References 111 publications

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“…Several studies have reported that 80 kVp abdominal CT can be used effectively while reducing radiation dose in patients with normal BMI [29][30][31][32]. Studies have also reported that reducing the tube voltage from 120 kVp to 80 kVp resulted in a 48-65% dose reduction using either an identical tube current or automated tube current modulation [33][34][35]. However, extremely low tube voltage scans may result in noisier images that are inadequate for interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…DECT in abdomen has the advantage of analyzing CT images in various ways, including monoenergetic image analysis, liver fat and iron quantification, urinary calculi characterization, and gallstone imaging [12,33,34]. Unlike previous studies [14,28] that suggested routine use of DECT, our study found that the performance alone was not sufficient to justify routine use of DECT for oncology patients who frequently undergo CT examinations, sometimes every 1-2 months, because the radiation dose is higher with 80/Sn150 kVp CT compared 80 kVp CT.…”

Section: Discussionmentioning

confidence: 99%

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Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

Choi

Ahn

Choi³

et al. 2020

Preprint

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ObjectiveTo compare the radiation dose, objective and subjective image quality, and diagnostic performances of 80 kVp and 80/150 kVp with tin filter (80/Sn150 kVp) computed tomography (CT) in oncology patients. MethodsOne hundred forty-five consecutive oncology patients who underwent third-generation dualsource dual-energy CT of the abdomen for evaluation of malignant visceral, peritoneal, extraperitoneal, and bone tumor were retrospectively recruited. Two radiologists independently reviewed each observation in 80 kVp CT and 80/Sn150 kVp CT. Modified line-density profile of the tumor and contrast-to-noise ratio (CNR) were measured. Diagnostic confidence, lesion conspicuity, and subjective image quality were calculated and compared between image sets. ResultsModified line-density profile analysis revealed higher attenuation differences between the tumor and the normal tissue in 80 kVp CT than in 80/Sn150 kVp CT (127 vs. 107, P = 0.05).The 80 kVp CT showed increased CNR in the liver (8.0 vs. 7.6) and the aorta (18.9 vs. 16.3) than the 80/Sn150 kVp CT. The 80 kVp CT yielded higher enhancement of organs (4.9 ± 0.2 vs. 4.7 ± 0.4, P < 0.001) and lesion conspicuity (4.9 ± 0.3 vs. 4.8 ± 0.5, P = 0.035) than the 80/Sn150 kVp CT; overall image quality and confidence index were comparable. The effective dose reduced by 45.2% with 80 kVp CT (2.3 mSv ± 0.9) compared to 80/Sn150 kVp CT (4.1 mSv ± 1.5). ConclusionsThe 80 kVp CT performed similar or better than 80/Sn150 kVp CT for abdominal tumor evaluation with 45.2% radiation dose reduction in oncology patients. Hepatobiliary 25 (17.2) Gastro-small bowel 24 (16.5) Breast 17 (11.7) Genitourinary 14 (9.7) Bronchial 8 (5.5) Others 10 (6.9) Reference standard Liver MRI and PET/CT 48 (33.1) PET/CT 37 (25.5) Pelvis MRI and PET/CT 18 (12.4) PET/CT and spine MRI 17 (11.7) Liver MRI, PET/CT, and surgery 15 (10.3) Liver MRI, PET/CT, and spine MRI 7 (4.8) Liver MRI and surgery 3 (2.0)Note. Data are presented as number (%), unless indicated otherwise.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

Choi

Ahn

Choi³

et al. 2020

Preprint

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“…Several studies have reported that 80 kVp abdominopelvic CT can be used effectively while reducing radiation dose in patients with a normal BMI [33][34][35][36]. Studies have also reported that reducing the tube voltage from 120 kVp to 80 kVp resulted in a 48-65% dose reduction using either an identical tube current or automated tube current modulation [37][38][39]. However, extremely low tube voltage scans may result in noisier images that are inadequate for interpretation.…”

Section: Plos Onementioning

confidence: 99%

“…Our results showed a balance between image noise and low-density lesion detectability while using low tube-voltage CT to evaluate solid organs. DECT of the abdomen has the advantage of analyzing CT images in various ways, including monoenergetic image analysis, liver fat and iron quantification, urinary calculi characterization, and gallstone imaging [15,37,38]. Another advantage of DECT is the faster acquisition time to discern the hemodynamic features from a moving organ (i.e., cardiac study) [40,41].…”

Section: Plos Onementioning

confidence: 99%

Dual-source abdominopelvic computed tomography: Comparison of image quality and radiation dose of 80 kVp and 80/150 kVp with tin filter

Choi

Ahn

Pak³

et al. 2020

PLoS ONE

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Objective To compare the radiation dose and the objective and subjective image quality of 80 kVp and 80/150 kVp with tin filter (80/Sn150 kVp) computed tomography (CT) in oncology patients. Methods One-hundred-and-forty-five consecutive oncology patients who underwent third-generation dual-source dual-energy CT of the abdomen for evaluation of malignant visceral, peritoneal, extraperitoneal, and bone tumor were retrospectively recruited. Two radiologists independently reviewed each observation in 80 kVp CT and 80/Sn150 kVp CT. Modified line-density profile of the tumor and contrast-to-noise ratio (CNR) were measured. Diagnostic confidence, lesion conspicuity, and subjective image quality were calculated and compared between image sets. The effective dose and size-specific dose estimate (SSDE) were calculated in the image sets. Results Modified line-density profile analysis revealed higher attenuation differences between the tumor and normal tissue in 80 kVp CT than in 80/Sn150 kVp CT (127 vs. 107, P = 0.05). The 80 kVp CT showed increased CNR in the liver (8.0 vs. 7.6) and the aorta (18.9 vs. 16.3) than the 80/Sn150 kVp CT. The 80 kVp CT yielded higher enhancement of organs (4.9 ± 0.2 vs. 4.7 ± 0.4, P<0.001) and lesion conspicuity (4.9 ± 0.3 vs. 4.8 ± 0.5, P = 0.035) than the 80/ Sn150 kVp CT; overall image quality and confidence index were comparable. The effective dose was reduced by 45.2% with 80 kVp CT (2.3 mSv ± 0.9) compared to 80/Sn150 kVp CT

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“…Evidence exists that a) better treatment response can be usually be predicted at perfusion CT before the beginning of therapy in more perfused tumours, and b) early perfusion response to CRT can be assessed before the onset of morphological changes at conventional morphological imaging. 37,38 On the other hand, DECT is emerging as an increasingly widespread imaging technique that can join the fast imaging time, high spatial resolution, and excellent morphological detail of multidetector CT with the possibility to collect functional data via material decomposition, allowing to calculate iodine content as a biomarker of tumour vascularity with a potentially lower overall radiation and contrast dose compared with standard single-energy CT imaging 39 ( Figure 2 ). DECT can be effective in improving the detection and local staging of primary tumours, with particular reference to N-staging, which is often limited due to small and/or morphologically indeterminate lymph nodes leading to inconclusive findings at conventional anatomical imaging.…”

Section: Oropharyngeal Cancermentioning

confidence: 99%

Imaging biomarkers in upper gastrointestinal cancers

2019

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In parallel with the increasingly widespread availability of high performance imaging platforms and recent progresses in pathobiological characterisation and treatment of gastrointestinal malignancies, imaging biomarkers have become a major research topic due to their potential to provide additional quantitative information to conventional imaging modalities that can improve accuracy at staging and follow-up, predict outcome, and guide treatment planning in an individualised manner. The aim of this review is to briefly examine the status of current knowledge about imaging biomarkers in the field of upper gastrointestinal cancers, highlighting their potential applications and future perspectives in patient management from diagnosis onwards.

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Dual-Energy Computed Tomography

Cited by 40 publications

References 111 publications

Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

Third-generation dual-source computed tomography of the abdomen: comparison of radiation dose and image quality of 80kVp and 80/150kVp with tin filter

Dual-source abdominopelvic computed tomography: Comparison of image quality and radiation dose of 80 kVp and 80/150 kVp with tin filter

Imaging biomarkers in upper gastrointestinal cancers

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