Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice

Blainski, Andressa; Piccolo, Vanessa K.; Mello, João Carlos Palazzo de; Oliveira, Rúbia Maria Weffort de

doi:10.1016/j.jep.2010.01.012

Cited by 35 publications

(15 citation statements)

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“…The OF test results showed an increase in the total number of crossings and in the number of central quadrants crossed, suggesting anxiolytic activity. Similar result was reported by Blainski et al (2010) who observed the same activity in OF and EPM tests conducted with extracts from different parts of the plant. The presence of metabolites such as polyphenols may have contributed to these results (Ariza et al, 2007).…”

Section: Discussionsupporting

confidence: 90%

“…As described by Blainski et al (2010), each animal was orally administered (gavage) with 900 mg/kg of Petiveria alliacea L. hydroalcoholic extract dissolved in saline solution (0.9% NaCl). This oral dose was chosen because the strongest effects of the whole plant extract were observed with this concentration.…”

Section: Animalsmentioning

confidence: 99%

“…However, chronic use causes profound changes in the CNS and opposite symptoms such as imbecility, weakness, seizures, and death after 1 year, depending on the dose. Indeed, Gomes et al (2008) and Blainski et al (2010) reported a possible CNS depressant action after administration of a Petiveria alliacea L. solution and alteration on motor functions and anxiety.…”

Section: Introductionmentioning

confidence: 99%

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Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Andrade

Melo

Dias

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 90%

Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Andrade

Melo

Dias

et al. 2012

Journal of Ethnopharmacology

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“…Además, análisis fitoquímico revela que su contenido de flavonoides es mayor en las partes aéreas (Blainski et al 2010). …”

Section: Discussionunclassified

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

2013

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ResumenLos radicales libres y el daño oxidativo están relacionados con la muerte celular, siendo la peroxidación lipídica un mecanismo que lleva a la destrucción oxidativa de la membrana celular. Además, en procesos inflamatorios, uno de los primeros estadios es la permeabilidad vascular incrementada (formación del edema) seguido de la extravasación de los fluídos, migración de leucocitos al sitio dañado y liberación de proteínas pro-inflamatorias. Evaluamos el efecto antioxidante y antiinflamatorio para Petiveria alliacea "mucura". Para el efecto antioxidante, se evaluó la formación de especies reactivas al ácido tiobarbitúrico como indicador de la peroxidación lipídica. Dosis 200mg/mL de Petiveria alliacea disminuyó significativamente en un 42% los niveles de MDA comparado con el agua (control negativo). En la evaluación antiinflamatoria, se indujo la inflamación por inyección de carragenina (solución al 1%), en la parte subplantar de ratones y en la "bolsa de aire subcutánea" de ratas para la inflamación aguda y crónica respectivamente. En la evaluación antiinflamatoria hay una máxima reducción del edema en un 23,26% a las 4 horas del tratamiento. Para la inflamación crónica hay una reducción del 25,9% y 29,5% del peso y volumen del exudado extraído, respectivamente, así como una reducción del 24% de peso de tejido fibroso. Estos resultados evidencian efecto antioxidante y antiinflamatorio de Petiveria alliacea.Palabras clave: Petiveria alliacea; antioxidante; antiinflamatorio; peroxidación; radical libre. AbstractThe free radicals and the oxidative damage are related with cellular death, with the lipid peroxidation being a mechanism that leads to oxidative destruction of the cellular membrane. Furthermore, in inflammatory process, one of the first stages is the incremented vascular permeability (formation of the oedema) followed with the extravasation of the fluids, migration of the leucocytes to the damaged site and release of pro-inflammatory proteins. Was evaluated antioxidants and anti-inflammatory of Petiveria alliacea "mucura". For antioxidants effect, was evaluated formation of thiobarituric acid reactive substances as indicator of lipid peroxidation. Doses 200 mg/mL of Petiveria alliacea decrease significatly in 42% levels of MDA compared to water (negative control). In the antiinflammatory evaluation, inflammation was analyzed in the carrageenan-induced paw oedema test in mice (solution to 1 %) and in the "carrageenan-induced air-pouch formation" of rates for acute and chronic inflammation respectively. In anti-inflammatory evaluation there is a significant reduction of the edema in 23.26% at 4hrs at the treatment. For chronic inflammation there is a reduction of 25.9% and 29.5% of the weight and volume of exuded extract respectively, as well as a reduction of 24% of weight of fibrous tissue. These results demonstrate antioxidant and anti-inflammatory effects of Petiveria alliacea.Keywords: Petiveria alliacea; antioxidant; anti-inflamatory; peroxidation; free radical. IntroducciónUn antioxidante se ...

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“…We reviewed the available literature on diazepam for the three major rodent ARDEB assays: EPM, OF and LD. This review identified 172 articles containing relevant data (Assie et al, 1993;Bahi et al, 2014;Barbosa et al, 2008;Baretta et al, 2012;Barnes et al, 1990;Bellavite et al, 2011;Belzung and Agmo, 1997;Bhatt et al, 2013;Bhattacharya and Mitra, 1991;Birkett et al, 2011;Blainski et al, 2010;Borsini et al, 1993;Brioni et al, 1994;Carneiro et al, 2005;Carro-Juarez et al, 2012;Cechin et al, 2003;Cha et al, 2005;Chen et al, 2004;Choleris et al, 2001;Cole and Rodgers, 1995;Colla et al, 2015;Consoli et al, 2007;Contreras et al, 2011;Costa et al, 2011;Costall et al, 1990;Da Silva et al, 1996;Dalvi and Rodgers, 2001;de A Vieira et al, 2013;de Almeida et al, 2012;de Castro et al, 2007;de Melo et al, 2006;de Sousa et al, 2007;de-Paris et al, 2000;Drapier et al, 2007;R. W. Dunn et al, 1989;1998;Ene et al, 2015;Engin et al, 2009;Ennaceur et al, 2010;Fajemiroye ...…”

Section: Summary Measuresmentioning

confidence: 99%

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

Mohammad

Ho²,

Lim

et al. 2015

Preprint

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Rodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety-modulating factors-genes, drugs and stressors-have had discordant effects across different studies. To reconcile the effect sizes of purported anxiety factors, we conducted systematic review and meta-analyses of the literature on ten anxiety-linked interventions, as examined in the elevated plus maze, open field and light-dark box assays. Diazepam, 5-HT1A receptor gene knockout and overexpression, SERT gene knockout and overexpression, pain, restraint, social isolation, corticotropin-releasing hormone and Crhr1 were selected for review. Eight interventions had statistically significant effects on rodent anxiety, while Htr1a overexpression and Crh knockout did not. Evidence for publication bias was found in the diazepam, Htt knockout, and social isolation literatures. The Htr1a and Crhr1 results indicate a disconnect between preclinical science and clinical research. Furthermore, the meta-analytic data confirmed that genetic SERT anxiety effects were paradoxical in the context of the clinical use of SERT inhibitors to reduce anxiety.

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Dual effects of crude extracts obtained from Petiveria alliacea L. (Phytolaccaceae) on experimental anxiety in mice

Cited by 35 publications

References 14 publications

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats

Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

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