Dual effects of a lectin from the green seaweed Caulerpa cupressoides var. lycopodium on inflammatory mediators in classical models of inflammation

Queiroz, Ismael Nilo Lino de; Quinderé, Ana Luíza Gomes; Rodrigues, José Ariévilo Gurgel; Vanderlei, Edfranck de Sousa Oliveira; Ribeiro, Natássia Albuquerque; Rivanor, Renata Line da Conceição; Ribeiro, Kátia Alves; Coura, Chistiane Oliveira; Pereira, Karuza Maria Alves; Chaves, Hellíada Vasconcelos; Bezerra, Mirna Marques; Araújo, Ianna Wivianne Fernandes de; Benevídes, Norma Maria Barros

doi:10.1007/s00011-015-0880-3

Cited by 14 publications

(13 citation statements)

References 32 publications

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“…For the treatment with C. cupressoides lectin no alteration of HO-1 expression was detected in TMJ, in spite of the results of a previous study showing that this lectin inhibited the immunoreactivity of HO-1, cytokines (IL-1β, IL-6 and TNF-α) and cyclooxygenase-2 in rat paws injected with carrageenan. 35 A HO-1 expression-dependent mechanism was also observed based on the treatment with T. toxicaria extract after the injection of zymosan in TMJ. 15 …”

Section: Discussionmentioning

confidence: 88%

The effect of natural products in animal models of temporomandibular disorders

et al. 2020

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The effect of natural products in animal models of temporomandibular disorders Treatment of temporomandibular disorders (TMD) is a challenge for health care professionals. Therefore, new approaches have been investigated, such as the use of natural products. Objective: This systematic review aims to summarize the natural products used in treatment of experimental models of TMD. Methodology: A systematic search was performed in the databases Medline, Web of Science, Scopus, Embase, SciELO, LILACS, and Scholar Google databases in January 2020, dating from their inception. Pre-clinical studies with natural products for intervention in experimental TMD were included. Two reviewers independently selected the studies, extracted the data, and evaluated the risk of bias. Results: 17 records were selected, and 17 different natural products were found, including three lectins, three plants or algae extracts, three sulfated polysaccharides, three cocoa preparations, and five isolated compounds. Concerning the risk of bias, most studies lacked on randomization and blinding. Nociception induced by phlogistic agents was evaluated in most articles, and in five studies it was associated with analysis of inflammatory parameters. In order to investigate the mechanism of action of the natural products used, eight studies evaluated expression of neural or glial molecular markers. Conclusions: 16 of 17 natural products found in this review presented positive results, showing their potential for treatment of TMD. However, the lack of methodological clarity can influence these results.

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Section: Discussionmentioning

confidence: 88%

The effect of natural products in animal models of temporomandibular disorders

et al. 2020

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“…For example, lectins from the green seaweed Caulerpa cupressoides var. lycopodium have anti-inflammatory activities, inhibiting cytokine production in carrageenan-induced rat-paw oedema models 31 . In contrast, lectins from the edible mushroom Agrocybe aegerita induce pro-inflammatory cytokine production by macrophages and promote the severity of caecal ligation and puncture-induced sepsis in mice 32 .…”

Section: Discussionmentioning

confidence: 99%

A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice

Chernikov

Wong

et al. 2017

Sci Rep

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A GalNAc/Gal-specific lectin (CGL) from the edible mussel Crenomytilus grayanus has been demonstrated to exhibit antibacterial properties. However, the mechanism of immune modulation by CGL in mammalian cells remains unclear. Here, we demonstrated that CGL can activate immune responses in macrophages and in mice. In the in vitro cell models, CGL induced tumour necrosis factor-α and interleukin-6 secretion in mouse RAW264.7 macrophages, mouse bone marrow-derived macrophages, human THP-1 macrophages, human peripheral blood mononuclear cells and human blood monocyte-derived macrophages. The CGL-mediated cytokine production was regulated by reactive oxygen species, mitogen-activated protein kinases, protein kinase C-α/δ and NF-κB. Interestingly, in lipopolysaccharide-activated macrophages, CGL induced endotoxin tolerance (characterized by the downregulation of nitric oxide, inducible nitric oxide synthase, interleukin-6 and cyclooxygenase II) via the downregulation of IRAK2 expression, JNK1/2 phosphorylation and NF-κB activation. CGL also slightly increased the bactericidal activity of macrophages and induced cytokine production in mouse models. Overall, our data indicate that CGL has the potential to be used as an immune modulator in mammals.

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“…The anti-inflammatory mechanism of a lectin from the green seaweed Caulerpa cupressoides var. lycopodium was investigated and showed that it decreased the carrageenan-induced rat paw edema and neutrophilic infiltration at 0.1, 1 or 10 mg/kg, and inhibited the expression of IL-1β, IL-6, TNFα and COX-2 at 1 mg/kg [ 68 ].…”

Section: Anti-inflammatory Bioactive Substances Derived From Marine Organismsmentioning

confidence: 99%

Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

Gao

et al. 2021

Marine Drugs

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Inflammation is the body’s defense reaction in response to stimulations and is the basis of various physiological and pathological processes. However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. The ocean gives birth to unique and diverse bioactive substances, which have gained special attention and been a focus for anti-inflammatory drug development. So far, numerous promising bioactive substances have been obtained from various marine organisms such as marine bacteria and fungi, sponges, algae, and coral. This review covers 71 bioactive substances described during 2015–2020, including the structures (65 of which), species sources, evaluation models and anti-inflammatory activities of these substances. This review aims to provide some reference for the research progress of marine-organism-derived anti-inflammatory metabolites and give more research impetus for their conversion to novel anti-inflammatory drugs.

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Dual effects of a lectin from the green seaweed Caulerpa cupressoides var. lycopodium on inflammatory mediators in classical models of inflammation

Abstract: The anti-inflammatory action of CcL involves the inhibition of IL-1β, TNF-α, IL-6 and COX-2 expression and histamine H1 receptors. When locally administered, CcL exerts pro-inflammatory actions.

Cited by 14 publications

References 32 publications

The effect of natural products in animal models of temporomandibular disorders

The effect of natural products in animal models of temporomandibular disorders

A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice

Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

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