Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

Abstract

Inflammation is the body’s defense reaction in response to stimulations and is the basis of various physiological and pathological processes. However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. The ocean gives birth to unique and diverse bioactive substances, which have gained special attention and been a focus for anti-inflammatory drug development. So far, numerous promising bioactive substances have been obtained from various marine organisms such as marine bacteria and fungi, sponges, algae, and coral. This review covers 71 bioactive substances described during 2015–2020, including the structures (65 of which), species sources, evaluation models and anti-inflammatory activities of these substances. This review aims to provide some reference for the research progress of marine-organism-derived anti-inflammatory metabolites and give more research impetus for their conversion to novel anti-inflammatory drugs.

Anti‐Inflammatory Effects of New Naphthyridine from Sponge Aaptos suberitoides in LPS‐Stimulated RAW 264.7 Macrophages via Regulation of MAPK and Nrf2 Signaling Pathways

“…To date, approximately 100 anti-inflammatory compounds have been isolated from marine sponges. [7] In this study, two new naphthyridines were isolated from the sponge A. suberitoides. Structurally, carbonyl and ketone groups were in opposite positions in compounds 1 and 2.…”

“…Marine sponges are a rich source of anti-inflammatory therapeutic agents. [7] Various anti-inflammatory compounds, such as peptides, terpenoids, and alkaloids, have been isolated from sponges. [8,9] Aaptos suberitoides Brøndsted of genus Aaptos (Porifera, Demospongiae, Suberitida, Suberitidae) are widely distributed in the marine ecosystem, including Vietnamese, Japanese, Indonesian, and Caribbean shallow waters.…”

Anti-inflammatory, anti-infectious and anti-cancer potential of marine algae and sponge: A review

“…However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. 107 Stylissatin A, a proline-rich cyclic heptapeptide extracted from the sponge, was reported to suppress NO production in LPS-induced murine RAW264.7 macrophage cells (EC 50 = 87 μM). 108 Recently isolated Dactylospongins A and B from sponge can inhibit the production of various cytokines in LPS-stimulated THP-1 cells.…”

The Plethora of Microbes with Anti-Inflammatory Activities

“…In the last decades, inflammation has turned into the main reason causing various diseases in human organisms. Inflammation is an immunological defensive response to external stimuli such as tissue injury, microbial pathogen infection, or chemical irritation and is the basis of a variety of physiological and pathological conditions [ 1 ]. This biological process includes the innate and adaptive immune system.…”