Dual-controlled release system of drugs for bone regeneration

et al. 2016

Pharmaceutical Biology

307

166

Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required. ARTICLE HISTORY

Section: Controlled Release Formulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of naringin: an overview

Chen

et al. 2016

Pharmaceutical Biology

307

166

“…As a key mediator of angiogenesis [15, 38], VEGF also has direct and indirect effects on bone formation [7, 43]. VEGF may increase vascular permeability after promoting local angiogenesis [43, 49].…”

Section: The Combined Application Of Vegf and Bmpsmentioning

confidence: 99%

“…There are mainly two strategies used in the codelivery of VEGF and BMPs. One of them is the expression of transgenes [19, 71–75] and the other is controlled release of growth factors from specific materials [38, 67, 76–78]. Transfected cell types in gene delivery and controlled release manners in material-based delivery can obviously influence the synergistic effects of VEGF and BMPs.…”

Section: Influencing Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Synergistic Effects of Vascular Endothelial Growth Factor on Bone Morphogenetic Proteins Induced Bone Formation In Vivo: Influencing Factors and Future Research Directions

BioMed Research International

Qiu

et al. 2016

Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs), as key mediators in angiogenesis and osteogenesis, are used in a combined delivery manner as a novel strategy in bone tissue engineering. VEGF has the potential to enhance BMPs induced bone formation. Both gene delivery and material-based delivery systems were incorporated in previous studies to investigate the synergistic effects of VEGF and BMPs. However, their results were controversial due to variation of methods incorporated in different studies. Factors influencing the synergistic effects of VEGF on BMPs induced bone formation were identified and analyzed in this review to reduce confusion on this issue. The potential mechanisms and directions of future studies were also proposed here. Further investigating mechanisms of the synergistic effects and optimizing these influencing factors will help to generate more effective bone regeneration.

Biomaterials Act as Enhancers of Growth Factors in Bone Regeneration

Chen

Liu

2016

Adv Funct Materials

Inspired by the physiological events of the “wound healing cascade”, the integration of biomaterials and growth factors is generally accepted as an emerging and powerful strategy for bone regenerative therapy. As a type of biological mediator, growth factors play a key role in functional bone regeneration. In this review, recent progress in the enhancement of bone‐related growth factors via a biomaterial strategy will be discussed. Two main reinforcing mechanisms, temporal regulation and efficacy manipulation, are described in detail, highlighting the potential capability of biomaterials to harness the interactions between growth factors and specific cells. The effects of biomaterials for promoting bone formation via growth factor‐mediated osteogenesis are further elucidated. Finally, an outlook of the prospects in terms of superior communication among growth factors, cells, and biomaterials in the microenvironment is presented, which might provide new directions for the design of medical devices for bone regeneration.