Therapeutic potential of naringin: an overview

Abstract

Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required. ARTICLE HISTORY

Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p‐Synephrine

“…Flavonoids as naringin and hesperidin are widely distributed in Citrus species and are known to exhibit antioxidant, antiinflammatory, hepatoprotective, antineoplastic, thermogenic, and lipolytic effects (see, for example, Stohs et al ., ; Choi et al ., ; Lee et al ., ; Stohs and Badmaev, ; Chen et al ., ). Fujita et al .…”

“…Flavonoids as naringin and hesperidin are widely distributed in Citrus species and are known to exhibit antioxidant, antiinflammatory, hepatoprotective, antineoplastic, thermogenic, and lipolytic effects (see, for example, Stohs et al, 2011c;Choi et al, 2015;Lee et al, 2015;Stohs and Badmaev, 2016;Chen et al, 2016). Fujita et al (2008) conducted a comparative evaluation of the inhibitory activity of 12 immature Citrus fruit extracts against cytochrome P450 isoforms and demonstrated that, although furanocoumarins are primarily responsible for inhibition of cytochrome P450, flavonoids are a contributing factor.…”

A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy

“…This compound shows a wide variety of pharmacological effects such as antioxidant, blood lipid-lowering and anticarcinogenic activity. Moreover, several studies have highlighted its potential to suppress the production of proinflammatory cytokines and attenuate the A C C E P T E D M A N U S C R I P T inflammatory response [7,8,9,10,11,12] and it has been proposed in combination with corticoids to treat skin diseases such as dermatitis [13].…”

Effect of the process, temperature, light and oxygen on naringin extraction and the evolution of its antioxidant activity

“…Naringin is found in the white spongy portion of citrus peel. Its content varies from 0.65 mg g À1 in mandarin peel to 14.40 mg g À1 in grapefruit peel (Zhang, 2007;Hayat et al, 2010;Chen et al, 2016).…”