Dual-channel fiber surface plasmon resonance biological sensor based on a hybrid interrogation of intensity and wavelength modulation

Abstract

We investigate an intensity and wavelength modulation combined plasmon resonance-based fiber-optic sensor technology. Composed of gold nanoparticles (GNPs) and sandwich configuration of Au/indium tin oxide (ITO)/Au film, two sensing regions are fabricated separately along with unclad portions of the fiber-optic probe. It can simultaneously monitor both the light intensity from the Au NP channel and the wavelength from the Au/ITO/Au film channel with a single detector. As the refractive index (RI) of the external environment changes, the transmission intensity and resonance wavelength in the two channels are modified, which provides an interrogation of intensity and wavelength modulation. The sandwich film structure is formed using magnetron sputtering technology, and the GNPs functioning as localized surface plasmon resonators are coated on a multimode optical fiber via the layer-by-layer method. The experimental results reveal that the RI sensitivities of the two sensing channels are 334.1% RIU?1 and 1963.2??nm/RIU, respectively. Based on the above sensing design, we conduct real-time and label-free monitoring of IgG/anti-IgG and Con A/RNase B biomolecular interaction. The resonant dips excited by different sensing modes make it more attractive as a multichannel surface plasmon resonance analysis technology, which is valuable in biological and life sciences research and rapid diagnostics.

Fluoride Fiber-Based Plasmonic Biosensor with Two-Dimensional Material Heterostructures: Enhancement of Overall Figure-of-Merit via Optimization of Radiation Damping in Near Infrared Region

“…The nature of the field distributions at resonance are in line with previously reported works on plasmonic sensors [40,41]. Higher electric field enhancement was observed for the Au-ITO-Au-coated fiber-optic SPR sensor than the Au-coated fiber-optic SPR sensor [40]. Furthermore, a magnetic field enhancement was reported at the ITO-Au-analyte interface in the case of fiber-optic SPR sensor designed for label-free and real-time monitoring of the IgG/anti-IgG biomolecular interaction [41].…”

“…Figure 6 shows the field variation of the BlueP/WS 2 heterostructure-based sensor structure under the corresponding ORD conditions (λ = 811.20 nm and d m = 38.2 nm) with N and MET tissues as the outermost media. The nature of the field distributions at resonance are in line with previously reported works on plasmonic sensors [40,41]. Higher electric field enhancement was observed for the Au-ITO-Au-coated fiber-optic SPR sensor than the Au-coated fiber-optic SPR sensor [40].…”

“…It is important to appreciate that the interaction volume plays an important role in plasmonic sensor characteristics. Some of the research works based on fiber-optic SPR sensors have also demonstrated the field distribution along the analyte side under resonance conditions [40,41]. The field enhancement towards the analyte region increases the interaction volume.…”

Multichannel Fiber Optic SPR Sensors: Realization Methods, Application Status, and Future Prospects

“…It can be derived from Equation (3) that the excitation of SPR is related to the RI and the structural parameters of the fiber optic, [56] the type of metal, the metal layer thickness, the incident angle of light and the RI of the object to be measured. Consequently, in order to excite multiple resonances under the condition of a single sensor to realize multichannel sensing, it is crucial to further adjust the structural parameters of the sensor or introduce some new materials on the basis of the original single SPR.…”

Design and Simulation of Photonic Crystal Fiber Based Surface Plasmon Resonance Biosensor for Cancer Diagnosis

“…SPR technology provides access to ultra-compact detection sensors and electronic devices [2]. Due to the sensitivity of SPR sensor to refractive index and label-free sensing capability, this sensor as a direct measuring device has many applications, such as environmental monitoring [3], food health [ 4], biological material detection [5], and film thickness monitoring [6].…”