Dual cancer targeting using estrogen functionalized chitosan nanoparticles loaded with doxorubicin-estrone conjugate: A quality by design approach

Kurmi, Balak Das; Paliwal, Rishi; Paliwal, Shivani Rai

doi:10.1016/j.ijbiomac.2020.08.172

Cited by 37 publications

(15 citation statements)

References 40 publications

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“…The future studies will undoubtedly focus on increasing biocompatibility since the cytotoxicity of nanoparticles or the products of their breakdown is still a significant. [38,39] Although nanomedicine and nanodrug delivery systems are well understood, their actual influence on the healthcare system-including in treating and detecting cancer -remains quite restricted. This is due to the field's youth in science, with just two decades of genuine research, and many critical and vital aspects remain unknown.…”

Section: Opportunities and Difficulties For The Futurementioning

confidence: 99%

Recent advancements in nanoparticles drug delivery systems

Choudhary¹,

Verma²,

Alsayadi³

et al. 2022

Pharmaspire

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Nanoparticles in drug-delivery systems are generated by a variety of research survey. Unique physicochemical characteristics of nanostructured biomaterials include their very small and structural adaptability, high surface area to mass ratio, high reactivity, and controlled size. It enables molecularly focused cancer treatment, targeted administration of early detection of cancer lesions, early detection of cancer lesions, imaging agents, and anticancer medications, identification of tumor molecular factors by non-invasive imaging. These characteristics may be used in medicine to get around some of the drawbacks of conventional treatments. They are employed in vivo to protect the drug entity in the systemic circulation, limit drug access to the targeted areas, and deliver the drug to the site of action at a regulated and sustained pace. It reduces adverse side effects and enables more effective drug use. It must be active and therapeutically effective while in circulation and present at the target location in the right amounts. We will now go through several elements of nanoparticle formulation, the impact of their properties, characterization, and the potential of nanomedicine, improving targeted delivery of therapeutic agents, applications in drug molecule delivery, the development of novel, more powerful diagnostic and screening techniques to expand the boundaries of molecular diagnostics, and difficulties in synthesis nanoparticle platforms for dispensing various drugs.

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Section: Opportunities and Difficulties For The Futurementioning

confidence: 99%

Recent advancements in nanoparticles drug delivery systems

Choudhary¹,

Verma²,

Alsayadi³

et al. 2022

Pharmaspire

Self Cite

View full text Add to dashboard Cite

show abstract

“…At initial screening, Ishikawa (fishbone) diagram and the early detection tools were used to identify and evaluate critical aspects that were connected with the overall risk of the method's performance. BBD is a response surface design characterized by a set of points positioned at the midpoint of each edge of a three‐dimensional cube and center copies of the response surface [24]. In the experimental setup, a BBD design comprised of a standard set of three variables and three levels to produce five center points for a total of 17 chromatographic conditions (Tables 1 and 2).…”

Section: Methodsmentioning

confidence: 99%

Quality by design assisted high‐performance liquid chromatography parameters for simultaneous estimation of simvastatin and fenofibrate

Rajput

Patel

Singh

et al. 2022

Separation Science Plus

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In a present study quality by design was used to develop a reliable highperformance liquid chromatography method for simultaneous estimation of simvastatin and fenofibrate. A robust chromatographic setting for quality peaks and appropriate component separation within a reasonable run duration was generated. Furthermore, to determine critical quality attributes (CQA), a quantitative relationship between critical material attributes and CQA was established using Box-Behnken design to produce analytical design space and develop a control approach. The mathematical models used three independent characteristics, acetonitrile volume, buffer molarity, and flow rate. The optimum and expected conditions were acetonitrile and potassium dihydrogen orthophosphate buffer (pH 2.9 adjusted, with orthophosphoric acid) (80.65:19.35 v/v) as an optimized mobile phase at a flow rate of 0.99 ml/min. We achieved adequate baseline separation of both drugs in just 10 min with these optimum parameters. The amount of acetonitrile was revealed to be the most important factor determining the perturbation plot responses. The %recoveries for both medicines were 99.15%-101.86% at all three levels. Both drugs showed relative standard deviations for repeatability, and intermediate precision were less than 2%. As a result, a simple, accurate, and repeatable high-performance liquid chromatography approach for routine quality control testing was developed.

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“…It has been reported that following intracellular uptake of estrogen-modified nanoparticles by receptor-mediated endocytosis, intracellular ERs can carry these nanoparticles toward the nucleus for nuclear targeting [ 88 ]. Furthermore, these receptors have been found overexpressed on several tumor cell surfaces.…”

Section: Receptor-mediated Active Targeting Strategymentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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Dual cancer targeting using estrogen functionalized chitosan nanoparticles loaded with doxorubicin-estrone conjugate: A quality by design approach

Cited by 37 publications

References 40 publications

Recent advancements in nanoparticles drug delivery systems

Recent advancements in nanoparticles drug delivery systems

Quality by design assisted high‐performance liquid chromatography parameters for simultaneous estimation of simvastatin and fenofibrate

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

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