Recent advancements in nanoparticles drug delivery systems

Abstract

Nanoparticles in drug-delivery systems are generated by a variety of research survey. Unique physicochemical characteristics of nanostructured biomaterials include their very small and structural adaptability, high surface area to mass ratio, high reactivity, and controlled size. It enables molecularly focused cancer treatment, targeted administration of early detection of cancer lesions, early detection of cancer lesions, imaging agents, and anticancer medications, identification of tumor molecular factors by non-invasive imaging. These characteristics may be used in medicine to get around some of the drawbacks of conventional treatments. They are employed in vivo to protect the drug entity in the systemic circulation, limit drug access to the targeted areas, and deliver the drug to the site of action at a regulated and sustained pace. It reduces adverse side effects and enables more effective drug use. It must be active and therapeutically effective while in circulation and present at the target location in the right amounts. We will now go through several elements of nanoparticle formulation, the impact of their properties, characterization, and the potential of nanomedicine, improving targeted delivery of therapeutic agents, applications in drug molecule delivery, the development of novel, more powerful diagnostic and screening techniques to expand the boundaries of molecular diagnostics, and difficulties in synthesis nanoparticle platforms for dispensing various drugs.

Adherence to national malaria treatment guidelines in private drug outlets: a cross-sectional survey in the malaria-endemic Kisumu County, Kenya

“…This appears to be contrary to findings from a mixed effects logistic regression modelling of predictors of presumptive malaria treatment in private drug outlets in a 2018 national survey, which suggested that supervisory visits only improved malaria treatment practices by 1% [ 17 ]. However, this study’s findings agree with a 2018 paper on rational drug use, which asserted that a proper regulatory framework, including monitoring of operations in a drug outlet, is critical for ensuring the appropriate use of medicines [ 37 ]. Similarly, these findings agree with an earlier national survey, which concluded that the quality of treatment in the private sector requires, among other things, proper regulation of outlets [ 35 ].…”

Peningkatan Pengetahuan Swamedikasi Toga-Toma Dan Kader Di Desa Pasirbatang Kecamatan Manonjaya Kabupaten Tasikmalaya Tahun 2023

“…6 Dari definisi tersebut maka penggunaan obat rasional harus memenuhi kriteria berikut: kesesuaian dengan indikasi; pemilihan obat yang didasarkan manfaat, keamanan, kesesuaian dan harga; pasien tidak memiliki kontraindikasi dan menunjukkan efek samping minimal; pasien menerima informasi mengenai kondisi medis dan obat yang relevan, akurat, dan jelas; serta adanya evaluasi atau monitoring efek yang tidak diharapkan selama pengobatan. 7 Penggunaan obat yang tidak rasional sebagian besar disebabkan oleh penggunaan terlalu banyak obat oleh satu pasien (polifarmasi), ketidaksesuaian penggunaan antibiotik seringkali dalam dosis yang tidak tepat untuk kondisi infeksi nonbakteri, kegagalan peresepan sesuai dengan panduan klinis, penggunaan obat berlebihan dan swamedikasi yang tidak tepat tanpa pergi ke fasilitas atau tenaga kesehatan. 6 Penggunaan obat tidak rasional dapat berdampak pada tidak tercapainya keberhasilan terapi, meningkatkan resiko efek samping, meningkatkan resiko resistensi antibiotik serta pemborosan biaya.…”

Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana

“…For example, a medication with a once-daily dosing schedule might be preferred over one with multiple doses to enhance patient compliance, especially in the elderly who are likely to forget and therefore miss some doses [9,11].…”

“…Once the goals are determined, a suitable treatment is chosen, which can be challenging due to the various available options [7]. Ideally, the final selection of medication should be made after conducting a comprehensive benefit–risk analysis, considering both the medical factors and the patient’s circumstances, including availability and cost [6,8,9]. Patient-related factors, such as physiological conditions (e.g., allergy, liver impairment), susceptibility to adverse effects, and concurrent drug therapy, may influence the medicine selection process by potentially leading to drug interactions [9,10].…”

“…Ideally, the final selection of medication should be made after conducting a comprehensive benefit–risk analysis, considering both the medical factors and the patient’s circumstances, including availability and cost [6,8,9]. Patient-related factors, such as physiological conditions (e.g., allergy, liver impairment), susceptibility to adverse effects, and concurrent drug therapy, may influence the medicine selection process by potentially leading to drug interactions [9,10]. Additionally, drug-related factors, such as safety and efficacy evidence, as well as pharmacokinetic and pharmacodynamic properties, may also play a role in the selection process.…”