Dual biorecognition by combining molecularly-imprinted polymer and antibody in SERS detection. Application to carcinoembryonic antigen

Carneiro, Mariana C.C.G.; Sousa‐Castillo, Ana; Correa‐Duarte, Miguel A.; Sales, M. Goreti F.

doi:10.1016/j.bios.2019.111761

Cited by 76 publications

(32 citation statements)

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“…Optical sensing methods such as high performance liquid chromatography (HPLC) and surface-enhanced Raman spectroscopy (SERS) require the use of expensive equipment and high maintenance costs [51]. Both SERS and HPLC can detect adsorption and analyte-specific recognition non-destructively, but cannot perform the electrocatalytic detection of analytes non-destructively [52,53]. Nanofibers can also be used in electronic type sensors (e.g., field effect transistors, chemiresistors); however, these types of sensors are subject to hysteretic effects that can lead to complex data analysis [54][55][56].…”

Section: Nanofiber Roles In Sensing Mechanismsmentioning

confidence: 99%

Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments

2021

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The use of nanofibers creates the ability for non-enzymatic sensing in various applications and greatly improves the sensitivity, speed, and accuracy of electrochemical sensors for a wide variety of analytes. The high surface area to volume ratio of the fibers as well as their high porosity, even when compared to other common nanostructures, allows for enhanced electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. Nanofibers have the potential to rival and replace materials used in electrochemical sensing. As more types of nanofibers are developed and tested for new applications, more consistent and refined selectivity experiments are needed. We applied this idea in a review of interferant control experiments and real sample analyses. The goal of this review is to provide guidelines for acceptable nanofiber sensor selectivity experiments with considerations for electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. The intended presented review and guidelines will be of particular use to junior researchers designing their first control experiments, but could be used as a reference for anyone designing selectivity experiments for non-enzymatic sensors including nanofibers. We indicate the importance of testing both interferants in complex media and mechanistic interferants in the selectivity analysis of newly developed nanofiber sensor surfaces.

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Section: Nanofiber Roles In Sensing Mechanismsmentioning

confidence: 99%

Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments

2021

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“…Recently RIfS-based sensors were used for the detection of single nucleotides [260] as well as oligonucleotides [261] and they showed high durability to thermal and physical stress. Such SERS biosensors have also been developed for early diagnosis of colorectal [238] and breast cancer [239] as well as for monitoring the therapeutic effects during cancer treatment [240,241]. AuNPs [242,243] and AgNPs [244] have frequently been exploited in SERS-based hormone investigations.…”

Section: Reflectometric Interference Spectroscopy Biosensorsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

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2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Based on the target recognition events, biosensor receptors are included. Based on the transduction mechanisms, biosensors can be classified into optical biosensor (Raman scattering [39][40][41][42][43][44], surface plasmon resonance (SPR) [6,[45][46][47], fiber Bragg grating [48][49][50][51][52][53], fluorescent [54-58], chemiluminescence [36,59]), electrochemical biosensor [60][61][62][63][64], calorimetric biosensor [6,22,[65][66][67][68][69], and piezoelectric biosensor [70][71][72][73][74].…”

Section: The Present Of Microfluidic-integrated Biosensorsmentioning

confidence: 99%

“…Carneiro M et al [41] reported the detection of carcinoembryonic antigen (CEA) in SERS using two different bioreceptors for CEA, i.e., a molecularly imprinted polymer (MIP) and a natural antibody. The MIP acted as a pre-concentration scheme for the CEA, while the natural antibody signals the presence of CEA on the MIP platform.…”

Section: Optical Biosensorsmentioning

confidence: 99%