Dual Agent Loaded PLGA Nanoparticles Enhanced Antitumor Activity in a Multidrug-Resistant Breast Tumor Xenograft Model

Chen, Yan; Zheng, Xuelian; Fang, Dingzhi; Yang, Yang; Zhang, Jinkun; Li, Huili; Xu, Bei; Lei, Yi; Ren, Ke; Song, Xiangrong

doi:10.3390/ijms15022761

Cited by 36 publications

(12 citation statements)

References 25 publications

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“…Every 2 days in this study, mice’s tumor volume and body weight were measured and recorded. Tumor volume ( V ) was obtained by the following formula: V = L × W 2 /2, in which W and L represented the shortest and longest diameter of tumor . Tumor inhibition ratio was calculated as follows where W c and W t represent the average tumor weight of the control group and treatment group, separately.…”

Section: Methodsmentioning

confidence: 99%

CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

Jiang

Zhang

et al. 2018

ACS Appl. Mater. Interfaces

148

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Quercetin (QT) is one promising candidate for the treatment of various cancers with virtually no toxic side effects. However, its anticancer effect is severely restricted by its poor bioavailability, low water solubility, and chemical instability in the neutral and alkaline medium. Herein, zeolitic imidazolate framework-8 (ZIF-8) is first reported as the multifunctional nanoplatform to the codelivery of quercetin as an anticancer agent and CuS nanoparticles as a photothermal therapy (PTT) agent for synergistic combination of chemotherapy and PTT as well as overcoming the drawbacks of quercetin. Moreover, folic acid-bovine serum albumin (FA-BSA) conjugates are applied to stabilize the CuS@ZIF-8-QT to promote the bioavailability of quercetin and realize active-targeting drug delivery. Near-infrared (NIR) fluorescent imaging demonstrated the highly increased drug accumulations of FA-BSA/CuS@ZIF-8-QT in tumors, resulting from efficient internalization via FA-receptors-mediated endocytosis. The results of in vivo and in vitro anticancer experiments demonstrate that quercetin and PTT agent can work together efficiently under NIR irradiation, thus remarkably improving the anticancer effect. Therefore, our newly designed FA-BSA/CuS@ZIF-8-QT multifunctional drug delivery system might be a promising nanoplatform for cancer treatment.

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Section: Methodsmentioning

confidence: 99%

CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

Jiang

Zhang

et al. 2018

ACS Appl. Mater. Interfaces

148

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“…These nanoparticles showed ameliorative potentials in combating skin cancer and therefore have a greater prospect of use in the therapeutic management of skin cancer. Similarly, significant anticancer activity was reported against osteosarcoma cancer cells (MG63 and Saos-2 osteosarcoma cell lines) by formulating PLGA nanoparticles of etoposide and paclitaxel ( 204 ). The results of quercetin-loaded PLGA nanoparticle administration showed potential action against C6 glioma cells ( 205 ).…”

Section: Drug Delivery Systems Entrapping Natural Bioactive Compounds...mentioning

confidence: 85%

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

et al. 2022

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Cancer is a prominent cause of mortality globally, and it becomes fatal and incurable if it is delayed in diagnosis. Chemotherapy is a type of treatment that is used to eliminate, diminish, or restrict tumor progression. Chemotherapeutic medicines are available in various formulations. Some tumors require just one type of chemotherapy medication, while others may require a combination of surgery and/or radiotherapy. Treatments might last from a few minutes to many hours to several days. Each medication has potential adverse effects associated with it. Researchers have recently become interested in the use of natural bioactive compounds in anticancer therapy. Some phytochemicals have effects on cellular processes and signaling pathways with potential antitumor properties. Beneficial anticancer effects of phytochemicals were observed in both in vivo and in vitro investigations. Encapsulating natural bioactive compounds in different drug delivery methods may improve their anticancer efficacy. Greater in vivo stability and bioavailability, as well as a reduction in undesirable effects and an enhancement in target-specific activity, will increase the effectiveness of bioactive compounds. This review work focuses on a novel drug delivery system that entraps natural bioactive substances. It also provides an idea of the bioavailability of phytochemicals, challenges and limitations of standard cancer therapy. It also encompasses recent patents on nanoparticle formulations containing a natural anti-cancer molecule.

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“…The highest inhibition of tumor growth in the MCF-7/ADR (Adriamycin) human breast tumor xenograft was observed in the co-encapsulated NPs group (tumor mass = 0.32 g, inhibition efficiency = 64.04%) in comparison to VCR (tumor mass = 0.83 g, inhibition efficiency = 6.74%), VCR–VRP free combination (tumor mass = 0.62 g, inhibition efficiency = 30.34%), and VCR–PLGANPs plus VRP–PLGANPs combination (tumor mass = 0.47 g, inhibition efficiency = 47.19%). The in vitro and in vivo studies showcased that co-encapsulation of VCR and VRP into PLGA NPs at synergistic ratio exhibited good antitumor efficacy in MDR MCF-7/ADR human breast tumor xenograft models (Chen et al, 2014). …”

Section: Nanoparticlesmentioning

confidence: 99%

PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs

2018

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Natural resources continue to be an invaluable source of new, novel chemical entities of therapeutic utility due to the vast structural diversity observed in them. The quest for new and better drugs has witnessed an upsurge in exploring and harnessing nature especially for discovery of antimicrobial, antidiabetic, and anticancer agents. Nature has historically provide us with potent anticancer agents which include vinca alkaloids [vincristine (VCR), vinblastine, vindesine, vinorelbine], taxanes [paclitaxel (PTX), docetaxel], podophyllotoxin and its derivatives [etoposide (ETP), teniposide], camptothecin (CPT) and its derivatives (topotecan, irinotecan), anthracyclines (doxorubicin, daunorubicin, epirubicin, idarubicin), and others. In fact, half of all the anti-cancer drugs approved internationally are either natural products or their derivatives and were developed on the basis of knowledge gained from small molecules or macromolecules that exist in nature. Three new anti-cancer drugs introduced in 2007, viz. trabectedin, epothilone derivative ixabepilone, and temsirolimus were obtained from microbial sources. Selective drug targeting is the need of the current therapeutic regimens for increased activity on cancer cells and reduced toxicity to normal cells. Nanotechnology driven modified drugs and drug delivery systems are being developed and introduced in the market for better cancer treatment and management with good results. The use of nanoparticulate drug carriers can resolve many challenges in drug delivery to the cancer cells that includes: improving drug solubility and stability, extending drug half-lives in the blood, reducing adverse effects in non-target organs, and concentrating drugs at the disease site. This review discusses the scientific ventures and explorations involving application of nanotechnology to some selected plant derived molecules. It presents a comprehensive review of formulation strategies of phytoconstituents in development of novel delivery systems like liposomes, functionalized nanoparticles (NPs), application of polymer conjugates, as illustrated in the graphical abstract along with their advantages over conventional drug delivery systems supported by enhanced biological activity in in vitro and in vivo anticancer assays.

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Dual Agent Loaded PLGA Nanoparticles Enhanced Antitumor Activity in a Multidrug-Resistant Breast Tumor Xenograft Model

Cited by 36 publications

References 25 publications

CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

Nano-Drug Delivery Systems Entrapping Natural Bioactive Compounds for Cancer: Recent Progress and Future Challenges

PhytoNanotechnology: Enhancing Delivery of Plant Based Anti-cancer Drugs

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