Dual active nanozyme-loaded MXene enables hyperthermia-enhanced tumor nanocatalytic therapy

Tang, Minglu; Shi, Yangtian; Lu, Liang; Li, Jingqi; Zhang, Zhaocong; Ni, Jiatong; Wang, Wenxin; Zhang, Yanhua; Sun, Tiedong; Wu, Zhiguang

doi:10.1016/j.cej.2022.137847

Cited by 41 publications

(21 citation statements)

References 58 publications

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“…To overcome the low activities of nanozymes in the tumor microenvironment that may cause the restricted therapeutic effects, MXene (Ti 3 C 2 )/CeO 2 -polyvinylpyrrolidone nanocomposites with photo-enhanced dual enzyme performances (promoting catalase and peroxidase) were constructed for synergistic tumor therapy (Fig. 2 ) [ 71 ]. The catalase- and peroxidase-like performance of these MXene-based nanozymes alleviated hypoxia and elevated oxidative stress in the tumor microenvironment; they also exhibited excellent capability for the degradation of glutathione to improve the tumor ablation.…”

Section: Biomedical Prospectsmentioning

confidence: 99%

“…These nanozymes could generate large amounts of ·OH via the catalytic decomposition of hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment, causing apoptosis of tumor cells. The photothermal effects and dual enzyme-like functions could result in improved tumor nanotherapy (the inhibitory effect of tumor growth was ~ 92%), paving the way for efficient nanozyme catalytic therapy [ 71 ]. Similarly, photothermal ablation of tumors by warming along with the increased ROS, O 2 formation, and glutathione reduction could alleviate the hypoxia of tumors and promote catalytic treatments with MnO 2 nanozyme-loaded MXenes.…”

Section: Biomedical Prospectsmentioning

confidence: 99%

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MXene-Based Composites as Nanozymes in Biomedicine: A Perspective

Iravani

Varma

2022

Nano-Micro Lett.

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MXene-based nanozymes have garnered considerable attention because of their potential environmental and biomedical applications. These materials encompass alluring and manageable catalytic performances and physicochemical features, which make them suitable as (bio)sensors with high selectivity/sensitivity and efficiency. MXene-based structures with suitable electrical conductivity, biocompatibility, large surface area, optical/magnetic properties, and thermal/mechanical features can be applied in designing innovative nanozymes with area-dependent electrocatalytic performances. Despite the advances made, there is still a long way to deploy MXene-based nanozymes, especially in medical and healthcare applications; limitations pertaining the peroxidase-like activity and sensitivity/selectivity may restrict further practical applications of pristine MXenes. Thus, developing an efficient surface engineering tactic is still required to fabricate multifunctional MXene-based nanozymes with excellent activity. To obtain MXene-based nanozymes with unique physicochemical features and high stability, some crucial steps such as hybridization and modification ought to be performed. Notably, (nano)toxicological and long-term biosafety analyses along with clinical translation studies still need to be comprehensively addressed. Although very limited reports exist pertaining to the biomedical potentials of MXene-based nanozymes, the future explorations should transition toward the extensive research and detailed analyses to realize additional potentials of these structures in biomedicine with a focus on clinical and industrial aspects. In this perspective, therapeutic, diagnostic, and theranostic applications of MXene-based nanozymes are deliberated with a focus on future perspectives toward more successful clinical translational studies. The current state-of-the-art biomedical advances in the use of MXene-based nanozymes, as well as their developmental challenges and future prospects are also highlighted. In view of the fascinating properties of MXene-based nanozymes, these materials can open significant new opportunities in the future of bio- and nanomedicine.

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Section: Biomedical Prospectsmentioning

confidence: 99%

Section: Biomedical Prospectsmentioning

confidence: 99%

MXene-Based Composites as Nanozymes in Biomedicine: A Perspective

Iravani

Varma

2022

Nano-Micro Lett.

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“…Previous work suggested that modulation of the wound microenvironment will benefit chronic wound healing and indicates a new direction for treatment strategies for diabetic wounds. ,− Currently, a series of materials designed for diabetic wound characteristics provide new therapeutic tools, such as an injected nanolipid emulsion to regulate the local inflammatory microenvironment, nanomaterials loaded with glucose oxidase to regulate the high glucose level at the wound, hydrogels for drug release in response to the pH and high glucose environment at the wound to promote healing, and an antioxidant hydrogel designed for the accumulation of reactive oxygen species in wounds . Nanoparticles have unique advantages in regulating the microenvironment due to their multispecies enzymatic activity − and distinctive pH-dependent properties, such as selectively increasing H 2 O 2 concentration in the tumor microenvironment to improve tumor therapeutic efficacy, alleviating tumor hypoxia to enhance oxidative stress in TME, and maintaining a normal microenvironment to improve flap survival . Our previous work has shown that platinum nanoparticles (Pt NPs) possess multiple enzymatic activities such as glucose oxidase (GOD)-like, peroxidase-like (POD), oxidase (OXD)-like, catalase (CAT)-like, and superoxide dismutase (SOD)-like, which can perform a specific function in different stages of the wound pH environment.…”

Section: Introductionmentioning

confidence: 99%

Nanohybrid Double Network Hydrogels Based on a Platinum Nanozyme Composite for Antimicrobial and Diabetic Wound Healing

Zhao

Mei

et al. 2023

ACS Appl. Mater. Interfaces

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Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory response hinders diabetic wounds from healing. It leads to the accumulation of large amounts of reactive oxygen species (ROS) and therefore prevents the transition of diabetic wounds from the inflammatory phase to the proliferative phase. In this work, a nanohybrid double network hydrogel with injectable, self-healing, and tissue adhesion properties based on a platinum nanozyme composite (PFOB@PLGA@Pt) was constructed to manage diabetic wound healing. PFOB@PLGA@Pt exhibited oxygen supply capacity and enzyme catalytic performance accompanied by pH self-regulation in the entire phases of wound healing. In the first stage, the oxygen carried by perfluorooctyl bromide (PFOB) can ameliorate the hypoxia and boost the glucose oxidase-like catalyzed reaction of Pt NPs, leading to a lowered pH environment with gluconic acid. As a result, the NADH oxidaselike, peroxidase-like, and oxidase-like multiple enzyme activities were activated successively, leading to synergistic antibacterial effects through the production of ROS. After the bacterial infection had cleared, the catalase-like and superoxide dismutase-like activities of Pt NPs reshaped the redox microenvironment by scavenging the excess ROS, which transitioned the wound from the inflammatory phase to the proliferative phase. The microenvironmentally adaptive hydrogel treatment can cover all phases of wound healing, showing the significant promoting effect in the repair of diabetic infected wounds.

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“…34 The major advantages of oxygen-producing BCNs are that their catalytic activity is adjustable and they can continuously decompose H 2 O 2 to produce oxygen in situ in hypoxic tumors. 35 In terms of hypoxia tumor microenvironment regulation, many oxygen-generating BCNs, such as MnO 2 , CeO 2 , and Pt nanoparticles (NPs), 36–38 have been used to alleviate tumor hypoxia. Oxygen-generating BCNs have made remarkable achievements in many tumor treatment methods, including chemotherapy, photodynamic therapy, RT, immunotherapy, and so on.…”

Section: Introductionmentioning

confidence: 99%