Dry particle coating for improving the flowability of cohesive powders

Yang, Jun; Slíva, Aleš; Banerjee, Amit; Davé, Rajesh N.; Pfeffer, Robert

doi:10.1016/j.powtec.2005.04.032

Cited by 371 publications

(208 citation statements)

References 15 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…Overall, the results presented show that the use of DMT model could provide a predictive rank ordering of the surface modified powders because of the observed one-to-one correlation between the Bond number (particle-scale measure) and unconsolidated bulk-scale measure such as the AOR. Since there is an increased need for surface modified powders for the purpose of improved flow and other properties [9][10][11][12], it is advantageous to utilize this approach to evaluate the differences between powder batches or different surface modifications. This approach could also help evaluate Active Pharmaceutical Ingredient (API) powders during early drug development where the amount of sample available is very small and a decision needs to be made regarding the best alternative particle formation process, processing conditions, that can provide optimal flow characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…The methods used for surface modification were dry particle coating for A7 and silane treatment of the surface of the aluminum particles for samples A2-A6. These methods have been extensively discussed in detail in [9,10] for dry coating and [32] for silane treated materials. The silane used in this work was methyltrichlorosilane (CH 3 SiCl 3 ) purchased from Sigma-Aldrich USA.…”

Section: Methodsmentioning

confidence: 99%

“…Dry coating has been shown to be efficient in reducing the interparticle adhesion forces for not only improving the flowability [10] but also fluidizabilty [11] of fine powders by precisely depositing small amounts of nanosized particles (called guest particles) on the surface of primarily cohesive powders (or host material). The deposits artificially generate nanoscale roughness, which can reduce the area of contact when two surfaces are in touch with each other.…”

Section: Introductionmentioning

confidence: 99%

“…The deposits artificially generate nanoscale roughness, which can reduce the area of contact when two surfaces are in touch with each other. Yang et al [10] found that the adhesion force between dry coated fine particles reduced in proportion to the ratio of the guest particle radius to the average asperity radius of the host particle, and is a major factor that contributes to the flow improvement.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness

Jallo

Chen

Bowen

et al. 2011

Journal of Adhesion Science and Technology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness

Jallo

Chen

Bowen

et al. 2011

Journal of Adhesion Science and Technology

View full text Add to dashboard Cite

“…There are several ways to improve the handling of fine powders. Whereas chemists prefer to use additives [1] to reduce adhesion and cohesion in order to improve the flowability and avoid agglomeration, physicists prefer to use air flow [2] or mechanical vibration [3] to achieve the same effect. The use of additives leads to a permanent altering of powder characteristics.…”

Section: Introductionmentioning

confidence: 99%

Vibration Assisted Handling of Dry Fine Powders

Dunst¹,

Bornmann²,

Hemsel³

et al. 2018

Preprint

View full text Add to dashboard Cite

Since fine powders tend strongly to adhesion and agglomeration, their processing with conventional methods is difficult or impossible. Typically, in order to enable the handling of fine powders, chemicals are added to increase the flowability and reduce adhesion. This contribution shows that instead of additives also vibrations can be used to increase the flowability, to reduce adhesion and cohesion, and thus to enable or improve processes such as precision dosing, mixing, and transport of very fine powders. The methods for manipulating powder properties are described in detail and prototypes for experimental studies are presented. It is shown that the handling of fine powders can be improved by using low-frequency, high-frequency or a combination of low-and high-frequency vibration.

show abstract

Particle Engineering of Polymers into Multifunctional Interactive Excipients

Mangal

Larson

Meiser

et al. 2015

Handbook of Polymers for Pharmaceutical Technologies

View full text Add to dashboard Cite

Both natural and man-made polymers are widely utilized as tablet binders and filler-binders. The physicochemical and mechanical properties such as particle size, shape and deformation behavior of polymeric binders are key in their effective use. Many such binders are applied as solution in a wet granulation process, which facilitate its facile distribution leading to improved effectiveness as a binder. Direct compression and dry granulation are recognized as routes with reduced process complexity and cost. These processes require a binder to be employed in a dry form and it can be more difficult to obtain a homogeneous distribution of a dry binder in a powder formulation. Therefore, these binders are required in high proportions to generate mechanically strong tablets. At lower proportions, they often are insufficient to create mechanically strong tablets. Recently, innovations in the generation of co-processed excipients have been proposed. Co-processing is a popular means of improving excipient functionalities, where two or more existing excipients are combined by some suitable means to generate new structures with improved and often combined functionalities as compared to the component excipients. Particle size reduction is known to improve the binder properties of an excipient, but also makes it highly cohesive and hard to blend. Via particle engineering, surface structure of smaller particles can be tailored to optimize the cohesive-adhesive balance (CAB) of the powder, allowing formation of interactive mixtures. This chapter reviews recent efforts to engineer surface-modified polymeric micro-excipient structures with the inherent ability to not only form an interactive mixture efficiently and provide flow enhancement, but also to create harder tablets at lower proportions. Hence, this approach represents a potential novel multifunctional prototype polymeric micro-excipient for direct compression and dry granulation processes.

show abstract

Dry particle coating for improving the flowability of cohesive powders

Cited by 371 publications

References 15 publications

Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness

Prediction of Inter-particle Adhesion Force from Surface Energy and Surface Roughness

Vibration Assisted Handling of Dry Fine Powders

Particle Engineering of Polymers into Multifunctional Interactive Excipients

Contact Info

Product

Resources

About