Dry Eye Signs and Symptoms Persist During Systemic Neutralization of IL-1β by Canakinumab or IL-17A by Secukinumab

Grosskreutz, Cynthia L.; Hockey, Hans-Ulrich; Serra, Denise; Dryja, Thaddeus P.

doi:10.1097/ico.0000000000000627

Cited by 17 publications

(20 citation statements)

References 26 publications

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“…Th-17 cells are shown to produce IL-17 that overlap with the peak severity of corneal epithelial disease [ 149 ]. A clinical trial using anti-IL-17 failed to improve dry eye in SS patients, which makes the role of Th17 cells in disease progression within LGs ambiguous [ 150 ].…”

Section: Adaptive Immune Cellsmentioning

confidence: 99%

Contributions of Major Cell Populations to Sjögren’s Syndrome

Witas

Gupta

Nguyen

2020

JCM

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Sjögren’s syndrome (SS) is a female dominated autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal glands and subsequent exocrine glandular dysfunction. SS also may exhibit a broad array of extraglandular manifestations including an elevated incidence of non-Hodgkin’s B cell lymphoma. The etiology of SS remains poorly understood, yet progress has been made in identifying progressive stages of disease using preclinical mouse models. The roles played by immune cell subtypes within these stages of disease are becoming increasingly well understood, though significant gaps in knowledge still remain. There is evidence for distinct involvement from both innate and adaptive immune cells, where cells of the innate immune system establish a proinflammatory environment characterized by a type I interferon (IFN) signature that facilitates propagation of the disease by further activating T and B cell subsets to generate autoantibodies and participate in glandular destruction. This review will discuss the evidence for participation in disease pathogenesis by various classes of immune cells and glandular epithelial cells based upon data from both preclinical mouse models and human patients. Further examination of the contributions of glandular and immune cell subtypes to SS will be necessary to identify additional therapeutic targets that may lead to better management of the disease.

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Section: Adaptive Immune Cellsmentioning

confidence: 99%

Contributions of Major Cell Populations to Sjögren’s Syndrome

Witas

Gupta

Nguyen

2020

JCM

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“…In addition, since inflammation is a key component in both ADDE and LDDE, we can target inflammatory cytokines to limit the damage in DED. Although systemic inhibition of IL-1β and IL-17 was found to be ineffective in Grosskreutz et al ,[35] it has been advised that both pro-inflammatory and anti-inflammatory cytokines be used in monitoring other anti-inflammatory treatments in DED patients. [12]…”

Section: Discussionmentioning

confidence: 99%

“…[834] However, in Grosskreutz et al , inhibition of IL-17 production by systemic administration of secukinumab could not influence the severity of dry eye. [35] Together with IL-6, its role in causing DED and as a biomarker for DED is well supported by a lot of literature.…”

Section: Use Of Tear Film Biomarkers In Dry Eye Without Systemic Inflmentioning

confidence: 98%

Role of tear film biomarkers in the diagnosis and management of dry eye disease

Fong

Shih

Lam

et al. 2019

Taiwan J Ophthalmol

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In recent years, there has been increasing scientific interest in the use of tear film biomarkers in the diagnosis and management of dry eye disease (DED), owing to their potential important roles in the pathogenesis of ocular surface damage, as well as the technical feasibility of tear sample collection techniques. An Entrez PubMed search was conducted on March 2, 2019, to include papers investigating the use of tear film biomarkers in DED, and the results were classified according to whether the DED is associated with systemic inflammatory disease or not and further classified within each section according to the molecular nature of the biomarker for further discussion. A total of 58 relevant articles were reviewed. Certain cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha, IL-17, and IL-8, were found by a number of studies to consistently reflect disease severity well and had strong correlations with tear film metrics and tests for ocular surface damage in dry eye without systemic inflammatory disease. For dry eye with systemic inflammatory disease, IL-17, IL-8, and IL-1 receptor antagonists were shown to be consistently higher in affected eyes and correlated well with ocular surface disease severity in more than one type of inflammatory disease. With the advancement in technology and lowered costs in the future, tear film biomarker counts would allow better diagnosis and monitoring of DED, as well as facilitate personalized treatment strategies.

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“…Inflammatory cytokines, such as IL-1β, play an important role in the pathogenesis of DED [ 26 , 27 ]. Lam et al [ 28 ] found that IL-1β expression levels were increased in the tears of patients with DED, and Simmons et al [ 29 ] reported that IL-1β levels were significantly upregulated in the conjunctiva and CE of a murine dry eye model.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery

Hong¹,

Zhu²,

Zhang³

et al. 2017

IJMS

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The success rate of glaucoma filtration surgery is closely related to conjunctival inflammation, and the main mechanism of dry eye disease (DED) is inflammation. The aim of this study was to evaluate the effect of DED on bleb scar formation after rabbit glaucoma filtration surgery. Sixteen New Zealand white rabbits were randomly divided into control and DED groups. A DED model was induced by twice-daily topical administration of 0.1% benzalkonium chloride (BAC) drops for three weeks. Ocular examinations were performed to verify the DED model. Surgical effects were assessed, and histologic assessments were performed on the 28th postoperative day. Higher fluorescein staining scores, lower basal tear secretion levels and goblet cell counts, and increased interleukin 1β (IL-1β) levels were observed in the DED group. The DED eyes displayed significantly higher intraocular pressure (IOP)% on the 14th postoperative day; a smaller bleb area on days 14, 21 and 28; and a shorter bleb survival time. Moreover, proliferating cell nuclear antigen (PCNA) and alpha-smooth muscle actin (α-SMA) levels were significantly increased in the DED group. These results demonstrate that DED promotes filtering bleb scar formation and shortens bleb survival time; these effects may be mediated via IL-1β.

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Dry Eye Signs and Symptoms Persist During Systemic Neutralization of IL-1β by Canakinumab or IL-17A by Secukinumab

Cited by 17 publications

References 26 publications

Contributions of Major Cell Populations to Sjögren’s Syndrome

Contributions of Major Cell Populations to Sjögren’s Syndrome

Role of tear film biomarkers in the diagnosis and management of dry eye disease

The Effect of Dry Eye Disease on Scar Formation in Rabbit Glaucoma Filtration Surgery

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