Drugs versus placebo for dysthymia

Lima, Maurí­cio Silva de; Soares, Bernardo

doi:10.1002/14651858.cd001130

Cited by 38 publications

(1 citation statement)

References 129 publications

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“…Interestingly, this effect was indeed found for psychotherapy in dysthymia, 16 another form of chronic depression, but the efficacy of ADs in dysthymia is well established. 42 Although in the DSM-5, chronic depressive disorder is proposed as a combination of dysthymic disorder and cMDD, the conclusion of our review lends some support for the idea that the treatment effect for ADs differs between patients with dysthymic disorder and cMDD. It is possible that TRD also is at stake in this respect and that studies that included dysthymic patients did not select many patients with TRD in contrast to studies of patients with cMDD.…”

Section: Resultsmentioning

confidence: 50%

Psychotherapy, Antidepressants, and Their Combination for Chronic Major Depressive Disorder: A Systematic Review

Spijker

Straten

Bockting³

et al. 2013

Can J Psychiatry

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Objective: Recommendations for treatment of chronic major depressive disorder (cMDD) are mostly based on clinical experiences and on the literature on treatment-resistant depression (TRD) but not on a systematic review of the literature. Method:We conducted a systematic review of 10 randomized controlled trials (RCTs), with 17 comparisons between antidepressants (ADs), psychotherapy, or the combination of both interventions. Results:The best evidence is for the combination of psychotherapy and ADs, and especially for the combination of the cognitive behavourial analysis system of psychotherapy and ADs. Evidence is very weak for both ADs alone and psychotherapy alone. Assessment of TRD was mostly absent in the studies. Conclusion:The best treatment for cMDD is a combination of psychotherapy and ADs. However, there is a lack of well-performed RCTs in both ADs and psychotherapy and their combination for cMDD. Therefore, the conclusions are preliminary.

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Section: Resultsmentioning

confidence: 50%