Drugs that may provoke Kounis Syndrome

Rodrigues, Maria Catarina Luís; Coelho, D.; Granja, Cristina

doi:10.1016/j.bjane.2013.04.007

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Th e mechanism of Kounis syndrome (KS) involves release of infl ammatory cytokines through mast cell activation, which leads to coronary artery vasospasm and/or atheromatous plaque erosion or rupture (2). KS has been described with multiple conditions, including a variety of environmental exposures and drugs (3). More recently, variant presentations of allergic angina have been described.…”

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confidence: 99%

Allergic Acute Coronary Syndrome (Kounis Syndrome)

Memon

Chhabra

Masrur

et al. 2015

Baylor University Medical Center Proceedings

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Anaphylaxis rarely manifests as a vasospastic acute coronary syndrome with or without the presence of underlying coronary artery disease. The variability in the underlying pathogenesis produces a wide clinical spectrum of this syndrome. We present three cases of anaphylactic acute coronary syndrome that display different clinical variants of this phenomenon. The main pathophysiological mechanism of the allergic anginal syndromes is the inflammatory mediators released during a hypersensitivity reaction triggered by food, insect bites, or drugs. It is important to appropriately recognize and treat Kounis syndrome in patients with exposure to a documented allergen.

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confidence: 99%

Allergic Acute Coronary Syndrome (Kounis Syndrome)

Memon

Chhabra

Masrur

et al. 2015

Baylor University Medical Center Proceedings

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“…Kounis syndrome is an Acute Coronary Syndrome (ACS) in the setting of anaphylactic or anaphylactoid reactions in response to an allergic insult, including food, insect bites or drugs (Table 1). 1 Subsequent mast cell and platelet activation induces the release of inflammatory mediators such as histamine, arachidonic acid products, platelet-activating factor, cytokines and chemokines. 2 In this context, coronary artery spasm in predisposed subjects (type I), plaque rupture (type II) or stent thrombosis (type III) can occur.…”

Section: Clinical Presentation and How To Reach Diagnosismentioning

confidence: 99%

Kounis syndrome after almonds ingestion: From the diagnostic approach to new therapeutic options

et al. 2021

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Acute coronary syndromes can develop with an unusual and challenging presentation. Kounis syndrome is a mostly overlooked Acute Coronary Syndrome (ACS) in the setting of anaphylactic or anaphylactoid reactions in response to an allergic insult that can lead to severe complications including cardiac arrest. A 52-yearold- man presented to the emergency department of our hospital because of acute transient loss of consciousness that developed some minutes after almonds ingestion. The complex diagnostic workup led to the diagnosis of vasospastic Kounis syndrome, an infrequent type of acute coronary syndrome, mostly overlooked, with challenging diagnostic and therapeutic features. Peculiarities on clinical presentation, the approach adopted by the emergency physician and the consultant cardiologist to achieve the correct diagnosis and our proposed management with a brief revision of the literature will be reported. Unusual clinical presentations of acute coronary syndromes represent part of the pitfalls that an emergency physician can face during the everyday practice. Prompt identification of these conditions is always struggling but of crucial importance to improve patient prognosis with a correct diagnostic work-up and therapeutic management.

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“…The system of Kounis condition (KS) includes arrival of provocative cytokines through pole cell enactment, which prompts coronary course vasospasm or potentially atheromatous plaque disintegration or crack [2]. KS has been depicted with various conditions, including an assortment of ecological openings and medications [3]. All the more as of late, variation introductions of unfavorably susceptible angina have been depicted.…”

Section: Introductionmentioning

confidence: 99%