Drugs prescribed for patients hospitalized in a geriatric oncology unit: Potentially inappropriate medications and impact of a clinical pharmacist

Deliens, Coralie; Deliens, Gaétane; Filleul, Olivier; Pepersack, Thierry; Awada, Ahmad; Piccart, Martine; Praet, Jean Philippe; Lago, Lissandra Dal

doi:10.1016/j.jgo.2016.05.001

Cited by 45 publications

(46 citation statements)

References 43 publications

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“…According to the list of PIPs considered and the intervention, these decreases ranged from 3% to 24%. 13,[16][17][18] In our study, reassessment led to a decrease of 11% to 22% of PIPs. Thus, the rate of PIPs maintained knowingly was high (78% of initial PIPs).…”

Section: Critical Resultssupporting

confidence: 53%

“…Other studies have also described a decrease in PIPs during hospitalization. According to the list of PIPs considered and the intervention, these decreases ranged from 3% to 24% . In our study, reassessment led to a decrease of 11% to 22% of PIPs.…”

Section: Discussionmentioning

confidence: 48%

“…Previous studies described the incidence of PIPs and the effect of interventions to reduce them. Intervention studies confirmed that some PIPs could be removed (3–24%). Alternatively, some could not be stopped and so were “prescribed knowingly.” The challenge is now to identify the reasons why a PIP should be maintained and to determine whether the risk of these prescriptions can be managed by monitoring their use.…”

mentioning

confidence: 92%

“…The rate was 34% in Northern Ireland and 49% in Italy using the Beers Criteria 11,12 and 32% in Belgium using the STOPP criteria. 13 In France, PIM prescription was estimated to be 28.2% according to the Beers Criteria, 14 18.3% to 66% 15,16 using the Laroche list and 69% of participants using the STOPP criteria. 17 The concept of PIP suggests that there are situations that justify their use.…”

mentioning

confidence: 99%

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Monitoring of Potentially Inappropriate Prescriptions in Older Inpatients: A French Multicenter Study

Pandraud-Riguet

Bonnet-Zamponi

Bourcier

et al. 2017

J American Geriatrics Society

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Section: Critical Resultssupporting

confidence: 53%

Section: Discussionmentioning

confidence: 48%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Monitoring of Potentially Inappropriate Prescriptions in Older Inpatients: A French Multicenter Study

Pandraud-Riguet

Bonnet-Zamponi

Bourcier

et al. 2017

J American Geriatrics Society

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“…Comprehensive medication review can identify potentially inappropriate medications in older people with cancer. A recent study investigated the effect of clinical pharmacist medication reviews for patients admitted to a geriatric oncology unit . Potentially inappropriate medications, as defined by the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions criteria, were reduced from 32% to 16%.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with use of falls risk–increasing drugs among patients of a geriatric oncology outpatient clinic in Australia: a cross‐sectional study

Turner

Tervonen

Shakib

et al. 2016

Evaluation Clinical Practice

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Older people with cancer are at increased risk of falling. Falls risk-increasing drugs (FRIDs), comprising psychotropics and medications that cause orthostatic hypotension, are a potentially modifiable risk factor for falls. The objective of this study was to determine the prevalence and factors associated with use of FRIDs in older people with cancer. Patients aged ≥70 years who presented to a hospital outpatient clinic between January 2009 and July 2010 were included in the study. Information on current medication use, falls in previous 6 months, and frailty criteria was collected. Multinomial logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CIs) for factors associated with levels of FRID use. Overall, 76.1% (n = 293) of 383 patients used FRIDs. This comprised psychotropics (31.2%, n = 120) and medications causing orthostatic hypotension (69.9%, n = 269). In total, 24.0% (n = 92) patients reported falling in the previous 6 months. Risk factors for falling were associated with use of psychotropics but not orthostatic hypotension drugs. Patients with a history of falls had increased odds of using psychotropics (≥3 psychotropics; OR 13.50; 95%CI, 2.64-68.94). Likewise, frail patients had increased odds of using psychotropics (≥3 psychotropics; OR 27.78; 95%CI, 6.06-127.42). Risk factors for falling were associated with the use of psychotropics. This suggests that clinicians either do not recognize or underestimate the contribution of medications to falls in this high-risk patient group. Further efforts are needed to rationalize medication regimens at the time of patients' first presentation to outpatient oncology services.

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Drug Interactions in Aging and Cancer

Maggiore¹

2018

Geriatric Oncology

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Drugs prescribed for patients hospitalized in a geriatric oncology unit: Potentially inappropriate medications and impact of a clinical pharmacist

Cited by 45 publications

References 43 publications

Monitoring of Potentially Inappropriate Prescriptions in Older Inpatients: A French Multicenter Study

Monitoring of Potentially Inappropriate Prescriptions in Older Inpatients: A French Multicenter Study

Factors associated with use of falls risk–increasing drugs among patients of a geriatric oncology outpatient clinic in Australia: a cross‐sectional study

Drug Interactions in Aging and Cancer

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