Drugs of Choice for Sedation and Analgesia in the Neonatal ICU

Detection and Management of Delirium in the Neonatal Unit: A Case Series

“…17 In the present case series, addition of quetiapine allowed for weaning of benzodiazepines and opiates, which are believed to be toxic. 18 Less agitation and sedation also allowed for improved oxygenation and rapid weaning of ventilator support.…”

Pediatric Dental Sedation Practice: Evolution and Current State-of-the-Art

“…Propofol has many desirable characteristics for procedural sedation and analgesia: extremely rapid onset, 49 substantial potency 50,51 that reliably produces effective conditions for procedural sedation and analgesia, extremely short recovery (5 to 15 min), 39 and high satisfaction to patients as a result of its antiemetic and euphoric properties. Large emergency department, 52,53 gastroenterology, 54,55 and critical care series 56,57 show that propofol can be given to children in these settings with good efficacy, apparent safety, and rapid recovery. The depth of sedation achieved is not well described in these reports, but usually seems to be at or beyond levels consistent with deep sedation.…”

Effects of Different Doses of Fentanyl on the Sedation of Infants Under Mechanical Ventilation; A Randomized Clinical Trial

“…6 Some sedative drugs, such as benzodiazepines and opioids, are used to reduce infants' stress and restlessness under mechanical ventilation. [7][8][9][10] Morphine and fentanyl are 2 opioid drugs that are used for this purpose. 11,12 Fentanyl is used in dosages ranging from 0.5 μg/kg to 4 μg/kg to sedate infants.…”