Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Polakowska, Magdalena; Orzelska‐Górka, Jolanta; Talarek, Sylwia

doi:10.1515/cipms-2016-0004

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…First nebivolol improves endothelial dysfunction that causes endothelial cells to initiate inflammation by the generation of reactive oxygen species and proinflammatory cytokines [ 22 ]. Second nebivolol increases the level of nitric oxide in vessel causing vasodilatation by interacting with L-arginine/nitric oxide pathway as inflammation blocks the ability of endothelium to generate nitric oxide and prostacyclin [ 23 ]. Finally nebivolol itself has strong antioxidant and anti-inflammatory potential by reducing the production of hs-CRP, interleukin-6 (IL-6), vascular adhesion molecule (VCAM-1), adiponectin, and leptin in hypertensive patients in various clinical studies [ 12 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Hussain

Saeed

Babar

et al. 2017

International Journal of Hypertension

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Background High value of neutrophil lymphocyte ratio (NLR) is a strong independent predictor and biomarker of ongoing vascular inflammation in various cardiovascular disorders. Objective The main focus of the study is to investigate the effect of nebivolol on NLR in mild to moderate hypertensive patients in comparison with metoprolol. In addition, BMI, blood pressure, TLC count, blood sugar, and lipid profile were also assayed before and after treatment. Materials and Methods In this 12-week prospective double-blinded randomized study, 120 patients with mild to moderate hypertension were randomly divided into two groups to prescribed daily dose of tab nebivolol 5–10 mg and metoprolol 50–100 mg, respectively, for 12 weeks. The data were analyzed using SPSS 16 software. Results A total of 100 patients completed the study. Both drugs lowered blood pressure significantly, nebivolol 20.5/10.5 and metoprolol 22.5/11.2 (p < 0.001) from baseline. Regarding inflammation, nebivolol reduced total leukocyte count (p = 0.005) and neutrophil count (p = 0.003) and increased lymphocyte count (p = 0.004) as compared to metoprolol. Similarly, nebivolol but not metoprolol significantly reduced NLR ratio (p = 0.07). Nebivolol improved lipid profile and blood sugar compared to metoprolol, but values were nonsignificant. Conclusion Nebivolol has a strong impact on reducing NLR, a marker of subclinical inflammation in hypertensive patients. Moreover NLR can be used as a disease and drug monitoring tool in these patients.

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Section: Discussionmentioning

confidence: 99%

Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Hussain

Saeed

Babar

et al. 2017

International Journal of Hypertension

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“…Nitrate medications (nitroglycerin, sodium nitroprusside, isosorbide derivatives, etc.) are pharmaceutical agents with vasodilator effect (Polakowska et al, 2016 ). Thus, medication with isosorbide nitrates as active compounds is often used to prevent angina attacks and in the prophylactic treatments of angina pectoris (Yao et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

et al. 2020

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Due to their effect of vasodilatation, isosorbide nitrates represent one of the most important and most used solutions for angina pectoris. Unfortunately, these compounds have multiple dose-related adverse drug reactions such as headache, weakness, mild dizziness, and occasionally heart rate changes, nausea, vomiting, and sweating. The main aims of this research were to obtain and to evaluate new polyurethane (PU) structures that can be used as a proper transmembrane carrier with an improved release kinetic. Chitosan-based PU structures were obtained by a polyaddition process between hexamethylene diisocyanate and a mixture of chitosan, butanediol, and polyethylene glycol in the presence of caffeine as a synthesis catalyst. The obtained samples (with and without isosorbide nitrates) were characterized regarding the encapsulation and release rate (UV-Vis spectra), chemical composition (FTIR), thermal stability (thermal analysis), morphology changes (SEM and SANS), and in vivo irritation tests. These methods revealed no significant differences between the two sample structures. Multipopulational structures with sizes between 73 and 310 nm, with an increased tendency to form clusters and a high resistance to heat (up to 280 • C), were obtained. This study presents an alternative administration of isosorbide derivatives based on a PU carrier with a high biocompatibility and a prolonged release.

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“…NG is an organic nitrate that reacts with thiols and other reducing substrates [11]. It is converted into 1, 2-glyceryl dinitrate and nitrite in the vascular smooth muscle cells, which is then metabolized by mitochondrial aldehyde dehydrogenase 2 with a half-life of 1-4 min [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

et al. 2019

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Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. Methodology Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion. Results NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation. Conclusions The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.

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Drugs modulating the L-arginine:NO:cGMP pathway – current use in therapy

Cited by 4 publications

References 44 publications

Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Nebivolol Attenuates Neutrophil Lymphocyte Ratio: A Marker of Subclinical Inflammation in Hypertensive Patients

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

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