Drugs in postmortem adipose tissues: evidence of antemortem deposition

Levisky, Joseph A.; Bowerman, David L.; Jenkins, Werner W.; Johnson, Deborah G.; Karch, Steven B.

doi:10.1016/s0379-0738(01)00397-8

Cited by 27 publications

(14 citation statements)

References 5 publications

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“…MDMA elicits potent stimulant effects in the CNS and periphery and is a popular recreational drug. It has been associated with fatal cases of ST when co-administered with other serotonergic drugs, particularly moclobemide [16,37,[53][54][55][56][57]. Some individuals reportedly administer this drug combination intending to potentiate the pharmacological effects of the drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Limitations of the research included post-mortem redistribution which can alter the concentration of drugs [29,57,[65][66][67][68] and the presence of multiple contributing drugs. This complicates the interpretation of any death particularly when an accurate history of drug intake in the time leading up to death, as well as the degree of neuroadaptation and tolerance to drugs, is largely unknown [29,66].…”

Section: Discussionmentioning

confidence: 99%

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Deaths involving serotonergic drugs

Pilgrim

Gerostamoulos

Drummer

2010

Forensic Science International

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Deaths involving serotonergic drugs

Pilgrim

Gerostamoulos

Drummer

2010

Forensic Science International

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“…after a plane crash or due to burning [1a]. In the cases of missing blood and urine, samples from liver, bile, muscle tissue and other organs are taken for toxicological analysis [2,3]. Due to faster putrefaction of internal organs, muscle tissue is longer available for analysis than internal organs.…”

Section: Introductionmentioning

confidence: 99%

Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

Schloegl¹,

Rost²,

Schmidt³

et al. 2006

Forensic Science International

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“…Many of the precursor solvents as well as ephedrine, pseudoephedrine, and methamphetamine, have lipophilic properties consistent with bioaccumulation, contributing to their potential for long-term adverse health effects. Levisky et al (2001) showed the deposition of methamphetamine and related chemicals in human tissues.…”

Section: Discussionmentioning

confidence: 99%

Methamphetamine exposure and chronic illness in police officers

Ross¹,

Sternquist

2011

Toxicol Ind Health

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Background: The medical literature reports health hazards for law enforcement personnel from repeated exposure to methamphetamine and related chemical compounds. Most effects appear transitory, but some Utah police officers with employment-related methamphetamine exposures developed chronic symptoms, some leading to disability. This report is of an uncontrolled retrospective medical chart evaluation of symptomatic officers treated with a sauna detoxification protocol designed to reduce the chronic symptoms and improve the quality of life. Methods: Sixty-nine officers consecutively entering the Utah Meth Cops Project were assessed before and after a treatment program involving gradual exercise, comprehensive nutritional support and physical sauna therapy. Evaluations included pre- and post-treatment scores of the Research and Development Corporation (RAND) 36-item Short Form Health Survey (SF-36) in comparison with RAND population norms, pre- and post-treatment symptom score intensities, neurotoxicity scores, Mini-Mental Status Examination, presenting symptom frequencies and a structured evaluation of treatment program safety. Results: Statistically significant health improvements were seen in the SF-36 evaluations, symptom scores and neurotoxicity scores. The detoxification protocol was well tolerated, with a 92.8% completion rate. Conclusions: This investigation strongly suggests that utilizing sauna and nutritional therapy may alleviate chronic symptoms appearing after chemical exposures associated with methamphetamine-related law enforcement activities. This report also has relevance to addressing the apparent ill effects of other complex chemical exposures. In view of the positive clinical outcomes in this group, broader investigation of this sauna-based treatment regimen appears warranted.

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Drugs in postmortem adipose tissues: evidence of antemortem deposition

Cited by 27 publications

References 5 publications

Deaths involving serotonergic drugs

Deaths involving serotonergic drugs

Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

Methamphetamine exposure and chronic illness in police officers

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