Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

Schloegl, Haiko; Rost, Thomas L.; Schmidt, Wolfgang; Wurst, Friedrich Martin; Weinmann, Wolfgang

doi:10.1016/j.forsciint.2005.03.024

Cited by 67 publications

(40 citation statements)

References 22 publications

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“…According to the available previous research, EtG and EtS together could be a reliable criterion for postmortem alcohol formation [11,13,15,16,23,27,28]. Therefore, in somewhat more than half of the cases studied in the present work, postmortem alcohol formation could be excluded with great certainty, as both EtG and EtS were detected in the media available for analysis.…”

Section: Discussionmentioning

confidence: 53%

“…However, a significant number of cases could not be classified with great certainty. The nonoxidative ethanol metabolites ethyl glucuronide (EtG) and ethyl sulfate (EtS) have previously been investigated as markers of antemortem formation of alcohol [11][12][13]. Stability has been studied quite thoroughly in vitro, indicating that EtG could be very unstable and totally disappear, at least from blood, if the corpse was subject to putrefaction before sample collection [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion

et al. 2009

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In postmortem toxicology, it could be difficult to determine whether a positive blood ethanol concentration reflects antemortem ingestion or postmortem synthesis of alcohol. Measurement of the nonoxidative ethanol metabolite ethyl glucuronide (EtG) has been suggested as a marker of antemortem ingestion of alcohol, but EtG might degrade postmortem which could make interpretation difficult. So far, the published articles concern EtG only. Another nonoxidative metabolite, ethyl sulfate (EtS), which is more stable, has therefore been included in this study. We present a material of 36 deaths where postmortem formation of ethanol was suspected and where both EtG and EtS were measured in blood and urine to assist the interpretation. In 19 cases, EtG and EtS were positive in the body fluids analyzed. The median concentration of EtG and EtS in blood was 0.4 (range 0.1-23.2) and 0.9 mg/L (range 0.04-7.9), respectively. The median concentration of EtG and EtS in urine was 35.9 (range 1.0-182) and 8.5 mg/L (range 0.3-99), respectively. In another 16 cases, there was no trace of EtG or EtS in the specimens analyzed. In one case, there was inconsistency between the results of EtG and EtS; they were both positive in urine, while only EtS was positive in blood. This study showed that, out of 36 cases, antemortem ingestion of alcohol was very likely in 19 and unlikely in 16, according to EtG and EtS results. In the last case, the interpretation was more difficult. One possible explanation would be postmortem degradation of EtG in blood.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion

et al. 2009

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“…Lastly, all EtGnegative tissue samples remained negative for up to 4 weeks of storage at room temperature, suggesting that the presence of EtG in body liquid or tissues prove alcohol consumption prior to death. In a subsequent study performed on several substrates (rib bone marrow, liver and skeletal muscle samples, fat tissue, urine, blood, and bile) from 12 autopsies, they observed that rib bone marrow could be helpful in detecting EtG concentrations in cases where other material was not available [28].…”

Section: Ethyl Glucuronide and Ethyl Sulphatementioning

confidence: 99%

Postmortem chemistry update part II

Palmière

Mangin

2011

Int J Legal Med

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As a continuation of "Postmortem Chemistry Update Part I," Part II deals with molecules linked to liver and cardiac functions, alcohol intake and alcohol misuse, myocardial ischemia, inflammation, sepsis, anaphylaxis, and hormonal disturbances. A very important array of new material concerning these situations had appeared in the forensic literature over the last two decades. Some molecules, such as procalcitonin and C-reactive protein, are currently researched in cases of suspected sepsis and inflammation, whereas many other analytes are not integrated into routine casework. As in part I, a literature review concerning a large panel of molecules of forensic interest is presented, as well as the results of our own observations, where possible.

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“…Dans les urines, l'EtG est détectable jusqu'à 80 heures après exposition [6]. Les applications de la détermination de l'EtG sont nombreuses comme l'illustre sa caractérisation dans des matrices non conventionnelles, telles que les tissus, les os [7], la sueur [8] ou encore les cheveux [9].…”

Section: éThyl Glucuronideunclassified

Les marqueurs de l'éthylisme chronique. Focus sur les approches immuno-chimiques

Kintz¹,

Villain²,

Mandel³

et al. 2009

Ann Toxicol Anal

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Résumé -Les différents marqueurs biologiques de la consommation d'alcool éthylique peuvent être répartis en 2 groupes : marqueurs directs (éthanol, éthyl glucuronide, éthyl sulfate, esters éthyliques d'acides gras, cocaéthylène) et marqueurs indirects (VGM, γ-GT, ASAT, ALAT, CDT). Si les marqueurs directs sont essentiellement utiles pour caractériser une intoxication aigue, l'introduction du cheveu a permis d'augmenter la fenêtre de détection et les applications du dosage de l'éthyl glucuronide. Les marqueurs indirects sont des paramètres biologiques dont l'augmentation peut être la conséquence d'une consommation importante et régulière d'éthanol. L'objet de cette revue est de faire le point sur la pertinence de chaque test, en portant une attention particulière sur les approches immuno-chimiques. Mots clés : Éthanol, addiction, éthylisme chronique, CDT, ethyl glucuronideAbstract -This review deals with the 2 types of markers of ethyl alcohol consumption, including direct markers (ethanol, ethyl glucuronide, ethyl sulfate, fatty acid ethyl esters, cocaethylene) and indirect markers (MCV, γ-GT, ASAT, ALAT, CDT). For each test, sensitivity and specificity will be discussed. A special focus will be given to immunochemistry methods.

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Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

Cited by 67 publications

References 22 publications

Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion

Practical use of ethyl glucuronide and ethyl sulfate in postmortem cases as markers of antemortem alcohol ingestion

Postmortem chemistry update part II

Les marqueurs de l'éthylisme chronique. Focus sur les approches immuno-chimiques

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