Drugs in exacerbation of psoriasis

Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.

“…Our findings may also provide a rationale for the observation that treatment with ␤ 2 -antagonists can exacerbate psoriasis, a Th1-type skin disorder (36). It may be that ␤ 2 -antagonists counteract the regulatory role that circulating catecholamines have on IL-12 produced by antigen-presenting cells in psoriatic skin.…”

The characteristics of severe forms of psoriasis on pigmented skins: A retrospective study of 102 cases in Dakar, Senagal

“…Sur le plan épidémiologique, les formes graves de psoriasis étaient fréquentes puisque représentaient 31% des psoriasis toute forme confondue. Cette fréquence élevée, pourrait être expliquée d'une part par l'utilisation inappropriée de certaines thérapeutiques telles que la pénicilline retard ou la corticothérapie orale dont ses effets délétères sur le psoriasis sont clairement établis [3]. D'autre part la forte utilisation des plantes médicinales traditionnelles chez nos malades constituerait des facteurs déclenchant ou précipitant l'évolution vers une forme grave de psoriasis [4].…”

A case of psoriasis worsened by atorvastatin

“…These drugs include lithium, synthetic antimalarials, tetracyclines, interferon, non-steroidal anti-inflammatory drugs, neuroleptics, certain anti-hypertensive drugs as β-adrenergic antagonists, Ca-antagonists and angiotensin-converting enzyme inhibitors and even tumor necrosis factor-alpha inhibitors. 1 Statins are known to have a number of cutaneous adverse effects including the induction of autoimmune diseases like systemic and subacute lupus erythematosus, dermatomyositis, polymyositis, lichen planus pemphigoides 2,3 and the drug reaction with eosinophilia and systemic symptoms (DRESS). 4 Statins have been also reported as a triggering factor of psoriasis.…”