Drugs from the Sea

Ruggieri, George D.

doi:10.1126/science.9691

Cited by 95 publications

(31 citation statements)

References 80 publications

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“…anemones have been found to possess compounds with antimicrobial, antileukemic, anticoagulant, and cardioactive properties (Ruggieri, 1976). Such species may be important in producing pharmaceuticals, such as anti-cancer drugs, or may serve as models for the synthesis of new and effective drugs.…”

Section: Part II Protected Areas For Coral Reefsmentioning

confidence: 99%

Marine and Coastal Protected Areas: A Guide for Planners and Managers

Salm¹,

Clark²

2000

246

180

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Section: Part II Protected Areas For Coral Reefsmentioning

confidence: 99%

Marine and Coastal Protected Areas: A Guide for Planners and Managers

Salm¹,

Clark²

2000

246

180

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“…A large number of compounds synthesized by marine organisms, plants and microorganisms have been studied to evaluate their potential biological therapeutic activities (Ruggieri, 1976;Cundliffe, 1981). Owing to the cytotoxic efficacies, some natural products exhibited cytotoxic properties and were found to be potent inhibitors of cellular metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen

Mutee¹,

Salhimi²,

Ghazali

et al. 2012

Afr. J. Pharm. Pharmacol.

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Breast cancer remains the most common cancer among women all over the world. Current chemotherapeutic drugs for breast cancer such as tamoxifen show severe side effects. Therefore, there is a focus toward new chemotherapeutic agents to be obtained from natural sources. This study was carried out to evaluate cytotoxic and apoptotic effects of the Acanthaster planci starfish extract compared to tamoxifen in human breast cancer MCF-7 cell line. The extract was obtained using phosphate buffered saline. MTS assay and Annexin V assay were performed to evaluate the cytotoxic effect and apoptotic effect, respectively. The extract was found to inhibit the growth of MCF-7 cells (IC 50 =15.6 µg/ml) and induced apoptosis (52.9% after 1 h treatment and 63.9% after 2 h treatment). This apoptotic effect was more potent and earlier than the apoptotic effect induced by tamoxifen. These data suggest that A. planci starfish extract may be utilized as potential chemotherapeutic agents to be used in the treatment of human breast cancer.

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“…Since ancient times, humans have attempted to understand and use ocean resources. For instance, the Chinese Pharmacopoeia contains several species from ocean resources for several disorders, such as pain, menstrual difficulties, abscesses, and cancer (Ruggieri, 1976).…”

Section: Introductionmentioning

confidence: 99%