Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen

Mutee, Ahmed Faisal; Salhimi, Salizawati Muhamad; Ghazali, Farid; Al-Hassan, Faisal Muti; Lim, Chung Pin; Ibrahim, Kamarruddin; Asmawi, Mohd Zaini

doi:10.5897/ajpp11.208

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Moreover, a recent study reports for the first time the isolation and the structural characterization of a novel cysteine-rich antimicrobial peptide from an extract of the coelomic epithelium of the starfish Asterina pectinifera [101]. Sometimes, the comparison of marine-derived compounds with drugs typically employed to treat tumors has been surprising, as demonstrated, for example, by the study conducted by Mutee et al [20] according to which the raw extract of A. planci was more effective compared to the chemotherapeutic drug Tamoxifen, commonly used against breast cancer. Moreover, some of the species from which the molecules have been extracted are edible, as in the case of sea urchins, sea cucumbers and even starfish that are included in the diet in some Asian countries, underlining the safety of natural substances compared to chemically synthesized.…”

Section: Discussionmentioning

confidence: 99%

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Bright Spots in the Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action

et al. 2019

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The fight against cancer represents a great challenge for researchers and, for this reason, the search for new promising drugs to improve cancer treatments has become inevitable. Oceans, due to their wide diversity of marine species and environmental conditions have proven to be precious sources of potential natural drugs with active properties. As an example, in this context several studies performed on sponges, tunicates, mollusks, and soft corals have brought evidence of the interesting biological activities of the molecules derived from these species. Also, echinoderms constitute an important phylum, whose members produce a huge number of compounds with diverse biological activities. In particular, this review is the first attempt to summarize the knowledge about starfishes and their secondary metabolites that exhibited a significant anticancer effect against different human tumor cell lines. For each species of starfish, the extracted molecules, their effects, and mechanisms of action are described.

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Section: Discussionmentioning

confidence: 99%

“…The crude extract of A. planci was tested against human breast cancer MCF-7 cell line by Mutee et al [20]. The study demonstrated that the extract has potent cytotoxic as well as apoptotic effects on human breast cancer MCF-7 cell lines compared to tamoxifen.…”

Section: Acanthaster Planci (Valvatida: Acanthasteridae)mentioning

confidence: 99%

Bright Spots in the Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action

et al. 2019

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“…This offers an advantage over 5-FU. According to National Cancer Institute (NCI) standard, compounds which produce IC 50 value lower than 20 μ g/mL are considered as active cytotoxic agents [41, 42]. According to definition, cytotoxic compounds are compounds that kill the cells directly while cytostatic compounds are substances that suppress cell-proliferation without killing the cells [43].…”

Section: Discussionmentioning

confidence: 99%

Cytostatic and Antiproliferative Activities of F5 Fraction ofCrinum amabileLeaf Chloroform Extract Showed Its Potential as Cancer Chemotherapeutic Agent

Lim

Yam

Asmawi

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants have been considered as promising sources of drugs in treating various cancers. Crinum amabile (C. amabile), a plant species from the Amaryllidaceae family, is claimed to be a potential source for cancer chemotherapeutic compounds. Here, we aimed to investigate the potential of C. amabile as an anticancer agent. Dried leaves of C. amabile were serially extracted and our findings showed that chloroform extract (CE) was shown to exhibit cytotoxic effect against all cancer cell lines used. This active extract was further fractionated in which F5 fraction was shown to possess the highest cytotoxicity among all fractions. F5 fraction was then tested in-depth through Annexin V/FITC apoptosis and DNA fragmentation assays to determine its apoptotic effect on MCF-7 cells. Results revealed that F5 fraction only showed induction of cell apoptosis starting at 72-hour treatment while DNA fragmentation was not detected at any of the concentrations and treatment periods tested. Meanwhile, cell proliferation assay revealed that F5 fraction was able to inhibit normal cell proliferation as well as VEGF-induced cell proliferation of normal endothelial cell (HUVECs). In conclusion, F5 fraction from C. amabile leaf CE was able to exhibit cytostatic effect through antiproliferation activity rather than induction of cell apoptosis and therefore has the potential to be further investigated as an anticancer agent.

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“…A few studies have been reported about the Persian Gulf Echinodermata and their biological effects. [ 26 ] In a study by Andersson et al ., the antibacterial and cytotoxic effect of saponin compounds of brittle star on leukemia cells was investigated. [ 27 ] Prabhu and Bragadeeswaran evaluated hemolytic and cytotoxic properties of Ophiocnemis marmorata [ 28 ] which is consistent with cytotoxic properties of E. mathaei extract in this study.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Screening of Marine Organisms from Persian Gulf

et al. 2018

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Background:Marine organisms produce a variety of compounds with pharmacological activities, including anticancer effects. They contain several secondary metabolites with interesting biological activities. This study attempted to find cytotoxicity of Hexane, Dichloromethane and Butanol partitions of Holothuria leucospilota and Echinometra mathaei.Materials and Methods:H. leucospilota and E. mathaei were collected from Persian Gulf. The animals were extracted by maceration with methanol-ethyl acetate (1:1). The H. leucospilota extract was partitioned by Kupchan method to hexane, dichloromethane, butanol, and water partitions. The cytotoxic activity of the extracts was investigated against HeLa (cervical cancer) and human umbilical vein endothelial cells cell lines by mitochondrial tetrazolium test assay after 72 h.Results:The cell survivals of HeLa cell were decreased by increasing the concentration of extracts. A significant reduction in cell viability at the doses of 30 (μg/ml) of dichloromethane (DCM) partition, 0.3, 3, and 30 (μg/ml) of ButOH partitions of sea cucumber, and 0.5 (μg/ml) of E. mathaei was observed. The median growth inhibitory concentration value of Hex, DCM, ButoH, and water partitions were 0.301, 0.21, 2.29, and 0.229 μg/ml, respectively.Conclusion:This study reveals that different partitions of H. leucospilota and total extract of E. mathaei have cytotoxic activity against cancer cell lines. More study is necessary to find the active metabolites in the more active partitions.

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Apoptosis induced in human breast cancer cell line by Acanthaster planci starfish extract compared to tamoxifen

Cited by 16 publications

References 24 publications

Bright Spots in the Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action

Bright Spots in the Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action

Cytostatic and Antiproliferative Activities of F5 Fraction ofCrinum amabileLeaf Chloroform Extract Showed Its Potential as Cancer Chemotherapeutic Agent

Cytotoxic Screening of Marine Organisms from Persian Gulf

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