Drugs for Treatment of Dyslipidemia Available in the USA

Streja, Elani; Streja, Dan

doi:10.1007/978-3-319-97765-2_13

Cited by 4 publications

(6 citation statements)

References 197 publications

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“…A remarkable finding of this study was that all types of lipid abnormalities decrease after the age of 60 years. Streja et al reported similar findings in a chapter about management of dyslipidemia in the elderly [ 9 ]. A possible explanation for this finding is that many people with dyslipidemia might die before the age of 60, leaving only a few surviving to this age.…”

Section: Discussionsupporting

confidence: 60%

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The Prevalence of Dyslipidemia among Jordanians

et al. 2018

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Background Dyslipidemia is one of the major modifiable risk factors for the development of cardiovascular disease and type two diabetes mellitus. Knowing the current prevalence of dyslipidemia is an important step for increasing awareness of the problem and for proper planning of health programs for prevention of its negative clinical effects. Methods A national population based household sample was selected from north, middle, and south regions of Jordan in 2017. A total sample of 4,056 aged between 18 and 90 years were included. Selected individuals were interviewed using a structured questionnaire and fasting blood samples were collected for biochemical measurements. Results The prevalence rates of hypercholesterolemia, hypertriglyceridemia, high LDL, and low HDL were 44.3%, 41.9% 75.9%, and 59.5%, respectively. Hypercholesterolemia in Jordan almost doubled from 23.0% in 1994 to 44.3% in 2017, and hypertriglyceridemia increased from 23.8% in 1994 to 41.9% in 2017. All lipid abnormalities decreased after the age of 60 years. Hypertension, diabetes, and obesity were all independently associated with hypercholesterolemia and hypertriglyceridemia. Conclusions Results of this study show that dyslipidemia is a widely prevalent health problem among adult Jordanian population and that the problem has substantially increased since 1994. Encouraging healthy lifestyle and healthy diet are the basis for prevention of dyslipidemia.

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Section: Discussionsupporting

confidence: 60%

“…A possible explanation for this finding is that many people with dyslipidemia might die before the age of 60, leaving only a few surviving to this age. Attrition or survival bias can decrease associations between harmful exposures and illnesses of aging [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Dyslipidemia among Jordanians

et al. 2018

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“…A remarkable finding of this study was that the prevalence rates of all dyslipidemia patterns declined after 60 years of T2DM patients’ age, with observed prevalence peaks at the age group of 40–49 years for high LDL-C, hypercholesterolemia, hypertriglyceridemia, and high TC/HDL ratio. Similar findings were reported previously, 2 , 35 , 36 These findings could be explained by the higher mortality rate of subjects with T2DM with dyslipidemia before the age of 60; thus, survival or attrition bias cannot be excluded. 35 …”

Section: Discussionsupporting

confidence: 89%

“…Similar findings were reported previously, 2 , 35 , 36 These findings could be explained by the higher mortality rate of subjects with T2DM with dyslipidemia before the age of 60; thus, survival or attrition bias cannot be excluded. 35 …”

Section: Discussionsupporting

confidence: 89%

Prevalence and Pattern of Dyslipidemia and Its Associated Factors Among Patients with Type 2 Diabetes Mellitus in Jordan: A Cross-Sectional Study

Quran¹,

Bataineh²,

Al-Mistarehi³

et al. 2022

IJGM

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Background Dyslipidemia and type 2 diabetes mellitus (T2DM) are growing health problems, particularly in developing countries. This study aimed to determine the prevalence and pattern of dyslipidemia and its associated factors among patients with T2DM. Methods A cross-sectional study was conducted among patients with T2DM attending Family Medicine Clinics in Jordan between August 2017 and March 2019. The socio-demographics, clinical features, medications, and laboratory findings were collected. These laboratory findings included high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TGs). Results A total of 870 patients with T2DM were included. The prevalence of dyslipidemia among patients with T2DM was 91.4%. The most common patterns of dyslipidemia were low HDL-C (66.2%), high LDL-C (62.1%), and hypertriglyceridemia (58.2%). Female gender, obesity, and hypertension were associated with diabetic dyslipidemia patterns. T2DM duration and poor glycemic control were associated with high LDL-C and hypercholesterolemia. Hypertriglyceridemia was associated with poor glycemic control and smoking. Conclusion Dyslipidemia is highly prevalent among patients with T2DM. Evidence –based interventions are needed to prevent and control dyslipidemia among patients with T2DM in Jordan.

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“…While TC and LDL-C progressively increase during a woman's lifespan to age ∼75 years (∼10 years later than men), TC, LDL-C and HDL-C levels appear to decrease in the subsequent years, independent of weight, lifestyle, and chronic diseases [54] . Although triglyceride levels tend to decrease after age 75 years [55] (dependent on underlying metabolic factors), levels are higher in older women compared to older men 56 ] and independently predict CVD mortality in older women [57] . However, controversy exists in the relation between HDL-C and LDL-C to cardiovascular risk in older individuals.…”

Section: Life Cyclementioning

confidence: 99%