Drugs causing fixed eruptions

Pasricha, JS

doi:10.1111/j.1365-2133.1979.tb05559.x

Cited by 102 publications

(57 citation statements)

References 8 publications

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“…3 The commonly used drugs causing FDE are antibiotics such as trimethoprim-sulfamethoxazole, penicillin, tetracycline and erythromycin followed by non-steroidal anti-inflammatory drugs (NSAIDS) like diclofenac sodium, aspirin, ibuprofen and naproxen and also some of the antiepileptics. 5 In this case, patient developed adverse reaction within one day following administration of doxycycline. Naranjo's algorithm (Naranjo, 1981) was used to determine a plausible reaction due to doxycycline.…”

Section: Discussionmentioning

confidence: 82%

Doxycycline induced generalized bullous fixed drug eruption – A case report

Selvaraj¹,

Deepa²,

Adhimoolam³

et al. 2013

Journal of Young Pharmacists

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Section: Discussionmentioning

confidence: 82%

Doxycycline induced generalized bullous fixed drug eruption – A case report

Selvaraj¹,

Deepa²,

Adhimoolam³

et al. 2013

Journal of Young Pharmacists

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“…In a study by Pasricha in 1987, tetracyclines were responsible for the maximum number of cases. 17 In a study by Gupta in 2003, cotrimoxazole accounted for the maximum number of cases. 18 However, this study shows concordance with a latest study on ADR in 2012, which reports increasing incidence of FDE with NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study on Cutaneous Adverse Drug Reactions

Asokan¹,

K²,

Samson³

2017

jemds

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BACKGROUNDAdverse drug reactions (ADR) are a legacy of the rapid and newer developments made in the field of pharmaceuticals worldwide every day. They represent an important but underestimated cause of morbidity, increased health expenditure, hospital admissions and even mortality.This study focuses on the various morphological patterns of cutaneous ADR, the causative drugs and the outcome of the reactions. It also aims to find out the probable causative drugs using an in vivo test in the form of patch test. MATERIALS AND METHODSThis is a descriptive study undertaken in the Department of Dermatology and Venereology, Medical College Hospital, Thiruvananthapuram, South India for a period of one year, which included 121 clinically diagnosed cases of cutaneous adverse drug reactions. RESULTS92 of them presented with complaints of skin lesions (96.7%); 24 patients had taken penicillins (19.8%) which was the predominant drug; 59 patients (48.8%) had developed reaction within 3 days of administration of the drug. Erythematous macules, papules and small plaques were noticed in 68 patients (56.2%); 43 patients (35.5%) had associated mucosal lesions with majority having involvement of more than one mucosal site. Patch test was done in 39 patients (32.2%) and a positive test result was obtained in 12 cases (9.9%). Exanthematous reactions were observed in 48 patients (39.7%) and urticaria and angioedema in 34 patients (28.1%). There were 18 cases (14.9%) in the SJS-TEN complex. Exanthematous reactions were commonly produced by anticonvulsants in 16 patients (33.33%). CONCLUSIONThis prospective descriptive study on cutaneous adverse drug reactions in 121 cases showed the commonest pattern of drug reaction being exanthematic type followed by urticaria/angioedema and SJS/TEN complex. The commonest offending drug group was NSAIDS, in which paracetamol and diclofenac were the commonest individual drugs imputed followed by anticonvulsants and antibiotics. Penicillins and cephalosporins were the commonest antibiotics responsible. The previously implicated carbamazepine as the commonest cause for severe cutaneous adverse reactions has been taken over by phenytoin as observed in this study. The in vivo patch test using the suspected offending drug as the antigen was positive in 30.7% of the tested cases indicating its role as an adjunct to clinical diagnosis as in a few earlier studies.

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“…However Tetracyclines were reported to be commonest as per Parischa JS. [10] NSAIDS like phenazone (Antipyrine), Metamizole and barbiturates as revealed by some older studies as most frequent agents, not widely used now a days. [3], [11] Total No.…”

Section: Authormentioning

confidence: 99%

Clinical Pattern of Fixed Drug Eruptions in a Tertiary Care Hospital of Southern Assam: A Prospective Study

Saha¹,

Gupta²,

Das³

et al. 2015

jemds

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BACKGROUND: Fixed drug eruption (FDE) is a type of very common cutaneous adverse drug reaction seen in day to day practices. It is very embarrassing to patients due to repeated recurrences and may cause cosmetic problem when present on exposed surface. AIMS: To study the clinical pattern of FDE and identify drugs commonly causing it among patients attending in a tertiary care hospital of southern Assam. MATERIALS AND METHODS: An observational, prospective study was conducted in

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Drugs causing fixed eruptions

Cited by 102 publications

References 8 publications

Doxycycline induced generalized bullous fixed drug eruption – A case report

Doxycycline induced generalized bullous fixed drug eruption – A case report

A Clinical Study on Cutaneous Adverse Drug Reactions

Clinical Pattern of Fixed Drug Eruptions in a Tertiary Care Hospital of Southern Assam: A Prospective Study

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