Doxycycline induced generalized bullous fixed drug eruption – A case report

Abstract

a b s t r a c tAdverse drug reactions are a major hazard of modern medicine. Fixed drug eruption, which is a cutaneous adverse drug reaction, is commonly seen with antimicrobials and analgesics. Here we report 37-year-old female with bullous fixed drug eruptions due to doxycycline administration.

Doxycycline induced generalized bullous fixed drug eruption

“…[ 10 ] Doxycycline is an antibiotic, belonging to the tetracycline group which is one of the common causes of classical FDE (macule/patch); however, rarely it may cause nongeneralized/localized bullous FDE[ 11 ] or generalized/multifocal bullous FDE. [ 12 ] In our case also, doxycycline has been implicated to cause GBFDE, along with mucosal involvement.…”

Multifocal fixed drug eruption to ceftazidime in a child with cystic fibrosis

“…2 Many drugs have been shown to induce FDE, especially antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). 3 To our knowledge, there is no report of FDE to ceftazidime.…”

“…4 The most frequently involved drugs are antibacterial agents and NSAIDs. 3,4 To our knowledge, there was no report of FDE to ceftazidime in the literature. However, two potential cases of ceftazidimeinduced FDE have been previously declared to the French Register of Pharmacovigilance.…”

Doxycycline-Associated Dual Cutaneous Adverse Reaction to the Drug (CARD): Case Report of Concurrent Photosensitivity and Morbilliform Exanthem to Doxycycline

“…Doxycycline CARD includes photosensitivity; also, patients may develop a morbilliform exanthem. Less common skin side effects include bullous eruptions, lupus-like eruptions, pigmentary disorders, and vasculitis [5][6][7][8]. The development of simultaneous or multiple doxycycline-induced CARD is unique; indeed, we are not aware of a previous description of this phenomenon.…”