Doxycycline induced generalized bullous fixed drug eruption

Podder, Indrashis; Chandra, Somodyuti; Das, Anupam; Gharami, Ramesh Chandra

doi:10.4103/0019-5154.174197

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Pathogenesis is not well known, but it is considered to be CD8+ mediated type 4 hypersensitivity reaction to certain drugs or their metabolites [ 2 ]. Tetracyclines, NSAIDs, sulphonamides, etc., are well-known culprit drugs [ 4 ]. The reappearance of lesions at the same sites on re-administration of the offending agent is its most unique feature [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…The reappearance of lesions at the same sites on re-administration of the offending agent is its most unique feature [ 1 ]. However, with every subsequent exposure, severity, and area of involvement may increase, and even generalized eruption may occur [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Generalized bullous fixed drug eruption is an unusual form of FDE where along with typical FDE lesions, the vesiculobullous eruption is seen in at least three of the six anatomical sites i.e., head and neck, front of the trunk, back, upper and lower limbs, and genitalia; or at least 10% of the body surface area [ 4 ]. In our case, blistering was noted over four anatomical regions in addition to the usual FDE eruptions, thereby fulfilling the above criteria for GBFDE.…”

Section: Discussionmentioning

confidence: 99%

“…Few blisters may sometime be present over the lesions. Generalized bullous fixed drug eruption (GBFDE) is an uncommon form that may be mistaken for other severe drug reactions like Steven-Johnson syndrome or toxic epidermal necrolysis [ 4 ]. Tadalafil-induced FDE is a rare phenomenon, with only a handful of cases documented in the literature, none of which to date have reported a GBFDE after tadalafil intake [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug

Sarawgi¹,

Rudra²

2023

Cureus

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Tadalafil is a phosphodiesterase-5 (PDE-5) inhibitor, an FDA-approved treatment for erectile dysfunction (ED), pulmonary arterial hypertension (PAH), benign prostate hyperplasia, etc. It is also widely used by otherwise healthy individuals for recreational purposes. Fixed drug eruption (FDE) is a distinctive type of adverse drug reaction in which every exposure to the offending medication leads to the appearance of lesions at the same ‘fixed’ sites. A sharply defined erythematous patch or plaque with a violaceous hue is typically seen. A clinical variant featuring classic FDE lesions along with blistering in at least three out of six anatomical sites or involving at least 10% of body surface area is known as generalized bullous fixed drug eruption (GBFDE). Tadalafil-induced FDE is in itself an uncommon phenomenon, with only a handful of documented cases, none of which seem to have reported GBFDE-type presentation post-tadalafil intake. Here, we present a case of GBFDE following tadalafil administration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug

Sarawgi¹,

Rudra²

2023

Cureus

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“…There have been numerous reports of patients with GBFDE whose skin findings resolved with discontinuation of the causative drug and supportive care alone [1,40,44,51,52]. However, topical steroids [53,54] as well as short courses of systemic steroids [1,[55][56][57][58][59][60][61][62], most commonly oral prednisone or prednisolone, are often used to treat GBFDE. Rarely, GBFDE requires transfer to a burn intensive care unit for aggressive wound care [24].…”

Section: Treatmentmentioning

confidence: 99%

A Review of Fixed Drug Eruption with a Special Focus on Generalized Bullous Fixed Drug Eruption

Anderson

Lee

2021

Medicina

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Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by the onset of rash at a fixed location on the body each time a specific medication is ingested. With each recurrence, the eruption can involve additional sites. Lesions can have overlying vesicles and/or bullae, and when they cover a significant percentage of body surface area, the eruption is referred to as generalized bullous fixed drug eruption (GBFDE). Due to the widespread skin denudation that can be seen in this condition, GBFDE may be confused clinically with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). While treatments described for GBFDE include supportive care, topical and/or systemic steroids, and, recently, cyclosporine, the mainstay of management involves identifying and discontinuing the causative drug. This review article will provide an overview of FDE with an emphasis on its generalized bullous variant.

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A case of fixed drug eruption induced by doxycycline, mimicking a symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)

Favrelière¹,

Hosteing

Jazeron

et al. 2020

Therapies

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Doxycycline induced generalized bullous fixed drug eruption

Cited by 8 publications

References 11 publications

Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug

Tadalafil-Induced Generalized Bullous Fixed Drug Eruption: A Rare Side Effect of a Common Drug

A Review of Fixed Drug Eruption with a Special Focus on Generalized Bullous Fixed Drug Eruption

A case of fixed drug eruption induced by doxycycline, mimicking a symmetrical drug-related intertriginous and flexural exanthema (SDRIFE)

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