Drugs Acting on the Hypothalamus-Anterior Pituitary Axis

Dikstein, S.; Fg, Sulman

doi:10.1097/00006254-196608000-00001

Cited by 5 publications

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“…When implanted into the median eminence, clomiphene citrate caused increased LH concentrations in the pituitary and plasma (Igarashi, Ibuki, Kubo, Hamioka, Yokata, Ebara & Matsumoto, 1967). Thus, clomiphene citrate may be regarded as an oestrogenic substance of low intrinsic activity, but with a high affinity for the oestrogen receptors of the hypothalamus and pituitary (Dikstein & Sulman, 1966). It can therefore be expected that very small doses stimulate gonadotrophin secretion by interfering with the negative feedback of oestrogen in the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Promethazine and Clomiphene on Gonadotrophin Secretion in the Rat

Koch¹,

Dikstein²,

Superstine³

et al. 1971

Journal of Endocrinology

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Promethazine and promethazine sulphoxide selectively inhibited gonadotrophin secretion in female rats. The effects obtained were: decrease in ovarian weight, reduction in the number of follicles and corpora lutea in the ovary, prolongation of the oestrous cycle and reduced amounts of gonadotrophin-releasing factors in the hypothalamus.Very small doses of clomiphene citrate (1-100 ng/kg) increased gonadotrophin secretion in female rats, as shown by an increase in ovarian weight, increase in the number of corpora lutea, shortening of the oestrous cycle and increased amounts of gonadotrophin-releasing factors in the hypothalamus. Higher doses of clomiphene citrate (1 \ g=m\ g\ p=m-\ 2mg/kg) produced the well-known inhibition of gonadotrophin secretion.The possible mechanism of action of these drugs is discussed.

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Section: Discussionmentioning

confidence: 99%