The Effect of Promethazine and Clomiphene on Gonadotrophin Secretion in the Rat

Abstract

Promethazine and promethazine sulphoxide selectively inhibited gonadotrophin secretion in female rats. The effects obtained were: decrease in ovarian weight, reduction in the number of follicles and corpora lutea in the ovary, prolongation of the oestrous cycle and reduced amounts of gonadotrophin-releasing factors in the hypothalamus.Very small doses of clomiphene citrate (1-100 ng/kg) increased gonadotrophin secretion in female rats, as shown by an increase in ovarian weight, increase in the number of corpora lutea, shortening of the oestrous cycle and increased amounts of gonadotrophin-releasing factors in the hypothalamus. Higher doses of clomiphene citrate (1 \ g=m\ g\ p=m-\ 2mg/kg) produced the well-known inhibition of gonadotrophin secretion.The possible mechanism of action of these drugs is discussed.

Postpartum Interval in Beef Cows Shortened by Enclomiphene2

“…High doses of clomiphene citrate have also been shown to inhibit LH and follicle stimulating hormone (FSH) release, while low doses either stimulated release or at least facilitated luteinizing hormone releasing hormone (LHRH) action in the rat (Schally et al, 1970;Koch et al, 1971). Administration of high-dose clomiphene citrate in primates (equal to 200 to 240 mg daily for 5 d, on a body-weight basis, to women) caused a marked decline in estradiol production and delay in ovulation (Marut and Hodgen, 1982).…”