Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Har, Aileen F.; Croffie, Joseph M.

doi:10.1007/978-3-319-43268-7_44

Cited by 2 publications

(1 citation statement)

References 241 publications

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“…The antispasmodic activity is related to the ability of certain medications (extracts of plants, fractions, or isolated substances) to prevent or interrupt the painful and involuntary contraction (spasm) of the intestinal smooth muscle (Forster et al, 1980;Hani, 2014;Har & Croffie, 2017;Monteiro et al, 2018). To study that activity and its likely mechanism of action in intestinal smooth muscle, segments of isolated jejunum from rats can be used.…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Monteiro

Costa

Martins³

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

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Aim: Since other species of the Bignoniaceae Family presented of antispasmodic activity, it was decided, by chemotaxonomic criterion, to determine the antispasmodic activity of the leaves of Arrabidaea brachypoda. Methodology: the segments of the rat jejunum were suspended in glass vats containing specific saline solution, at an appropriate temperature, and after stabilization period, were stimulated by a contractile agent to observe the inhibitory or relaxing effect of EH-FAB. Results: EH-FAB showed the presence of 10 compounds, mainly rutin and it has an antispasmodic activity as it inhibits the phasic component and relaxes the tonic component of the contraction in isolated rat jejunum. To assess the mechanism of antispasmodic action, cumulative curves to the CCh were performed in which a non-competitive antagonism was observed, due to a displacement of the control curve to the right and reduction of the maximum contraction effect (E max). Afterward, the participation of the calcium and/or potassium channels was evaluated by increasing the extracellular potassium, and it was observed that the EH-FAB relaxed the rat jejunum, suggesting the participation of the Ca 2+ channels. To corroborate that hypothesis, the EH-FAB was tested against cumulative curves to Ca 2+ in a free depolarizing solution of Ca 2+ , and it was observed that there was a shift of the curve to the right with a reduction in E max. Conclusions: EH-FAB presents antispasmodic activity in isolated rat jejunum and it is suggested to block the influx of Ca 2+ through voltage-gated calcium channels, signaling the therapeutic potential for the treatment of colic and/or diarrhea.

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Section: Introductionmentioning

confidence: 99%

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Monteiro

Costa

Martins³

et al. 2020

Rev. Ciênc. Farm. Básica Apl.

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Dysmotility in Esophageal Atresia: Pathophysiology, Characterization, and Treatment

Fauré

Grunder

2017

Front. Pediatr.

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Esophageal dysmotility is almost universal after esophageal atresia (EA) repair and is mainly related to the developmental anomaly of the esophagus. Esophageal dysmotility is involved in the pathophysiology of numerous symptoms and comorbidities associated with EA such as gastroesophageal reflux disease, aspiration and respiratory complications, and symptoms of dysphagia and feeding disorders. High-resolution esophageal manometry (HREM) has facilitated the characterization of the dysmotility, but there is an incomplete correlation between symptoms and manometrical patterns. Impedance coupled to HREM should help to predict the clinical outcome and therefore personalize patient management. Nowadays, the management of esophageal dysmotility in patients with EA is essentially based on treatment of associated inflammation related to peptic or eosinophilic esophagitis.

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Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Cited by 2 publications

References 241 publications

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Hydroalcoholic extract of leaves of Arrabidaea brachypoda (DC.) Bureau present antispasmodic activity mediated through calcium influx blockage

Dysmotility in Esophageal Atresia: Pathophysiology, Characterization, and Treatment

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