Drug Utilisation Pattern and Adverse Events in Patients with Chronic Kidney Disease Undergoing Maintenance Haemodialysis at a Tertiary Care Hospital of Odisha

Abhisek, P. Ansuman; Panda, Rajendra; Samal, Rajashree; Mohapatra, Namita; Mohanty, Srikanta

doi:10.7860/jcdr/2017/25444.10793

Cited by 7 publications

(11 citation statements)

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“…In the present study the most associated co-morbidity in the patients was hypertension followed anemia. This was in accordance with the studies by Abhisek et al and Al-Ramahi et al 14,15 In our study secondary hyperparathyroidism was found to be third most common associated co-morbidity. The average number of drugs per prescription in our study was 12.29.…”

Section: Discussionsupporting

confidence: 94%

“…16 The average number of drugs per prescription in CKD patients vary from 8 to 12.8 in various studies. 12,14,17,18 This practice of polypharmacy is a common finding in patients of chronic kidney disease due to associated co-morbidities. In our study 71.4% of the drugs were prescribed by generic name, this is in contrast to the previous studies where the percentage varied from 0 to 40.96%.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of prescription pattern in patients on maintenance hemodialysis

Tadvi¹,

Hussain²

2020

IJPP

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Background: Chronic kidney disease (CKD) is a world-wide public health problem associated with various complications. CKD patients undergoing hemodialysis have associated comorbidities and prescribing drugs rationally in these patients is a difficult task. Objective: To evaluate the prescribing patterns of medicines in CKD patients on maintenance hemodialysis. Methodology: A Cross-sectional, hospital-based observational study was conducted in King Khalid General Hospital, Al Majmaah for a period of one year. The records of patients in the given period were examined and data pertaining to prescriptions was analyzed. Results: A total of 41 prescriptions of patients were analyzed. The most common associated co-morbidity was hypertension in 82.9% of the patients, followed by anemia in 73.1% of patients and secondary hyperparathyroidism in 63.4% of the patients. 85.4% of the patients had more than one comorbidity. The total number of drugs prescribed was 504 and the average number of prescriptions per patient was 12.3. The percentage of drugs prescribed using generic name was 71.4 and 65.3% drugs prescribed were from the WHO essential drugs list. Total number of Fixed dose combinations used was only 1.2%. Conclusion:The study has generated a profile of drugs prescribed in CKD patients on maintenance hemodialysis in a secondary care hospital in Saudi Arabia. High number of medications were used per prescription in this study thus increasing the possibility of drug interactions and Adverse events. Further studies with special consideration for drug-drug interactions, adverse events and adherence need to be conducted.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Analysis of prescription pattern in patients on maintenance hemodialysis

Tadvi¹,

Hussain²

2020

IJPP

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“…Two patients were found between 18-20 and two above 80 years of age, this distribution shows that the age group of 41-60 were more prone to have CKD along with hypertension. According to a study conducted in Cuttack, majority of the patients were in the age group of 41-60 years compared to other age groups reflecting the similar pattern with our study years (Abhisek PA et al, 2017).…”

Section: Discussionsupporting

confidence: 87%

“…2012; Verberne WR et al, 2019).Another study in Odisha reveals the mean age of the hypertensive CKD patients was 49.26 ±11.46 years somewhat close to our study results that is 52.08 ± 15.14 years(Abhisek PA et al, 2017).…”

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confidence: 89%

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Study of Antihypertensive Drug Utilization Pattern in Chronic Kidney Disease Patients

Uprety

2019

Int. J. Drug Res. Tech

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Introduction: Hypertension is a chronic illness associated with high morbidity & mortality, with a rising number of patients with hypertension and chronic kidney disease, achieving blood pressure of less than 140/90 mm of Hg is challenging. Hence, there is a need for appropriate, safe, effective and economical study to find out the patterns of drug therapy. Objectives: To evaluate utilization patterns of antihypertensive agents in chronic kidney disease patients. Methodology: A prospective observational study was conducted for a period of 6 months in Jayanagar General Hospital, Bengaluru. We included 70 hypertensive CKD patients. Detailed patient information data were noted, and data entered in a preformed proforma in Microsoft Excel sheet for compilation and subjected to statistical analysis. Results: Total 70 case records of patients having chronic kidney disease were analysed. Mean age was 52.08 ± 15.14. CKD was more prevalent in males 38 (54.2%) and 32 (46.8%) females with male to female ratio of 2.3:2. Most of the patients (52.80%) belonged tote age group of 41-60 years. Among the anti-hypertensive agents, most frequently used was calcium channel blockers (91.4%), followed by diuretics (54.2%), Beta blockers (31.4%), alpha blockers, ACE inhibitors and ARB. Conclusion: Dual and triple therapy were prescribed which was according to ESH guidelines. This study highlights some therapeutic rationality in this health centre. However,

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A Prospective Observational Study on Medication Use Pattern in Patients With Risk Factors of Chronic Kidney Disease

Ali

Kumar

Ansari³

et al. 2021

Asian J Pharm Clin Res

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Objectives: The current study was undertaken to review and assess the medication usage pattern in patients with chronic kidney disease (CKD). Methods: A 12-month prospective observational study was carried out at Shadan Teaching and General Hospital, Peerancheru (Hyderabad), involving 384 CKD patients considering the inclusion and exclusion criteria. Medication evaluation for optimization was done using the World Health Organization (WHO) core prescribing indicators. Data collected were entered using Microsoft Excel. Descriptive statistics such as mean, percentage, and standard deviation (SD) were used to present sociodemographic characteristics of the study participants. Results: Out of the total of 384 patients, 249 (65%) were male and 135 (35%) were female with a mean age of 58.28 (SD: 13.12). A total of 384 prescriptions were scrutinized with a total of 3634 drugs, out of which drugs acting on the cardiovascular system were the most prescribed drugs (36.37%). The average number of drugs per prescription was found to be 9.08 considering the total number of prescriptions. The percentage of drugs prescribed by generic name was 15.57%. The percentage of encounters with antibiotics was 25%, whereas the percentage of encounters with injections was 86%. The percentage of drugs prescribed from the Essential Drug List or Formulary was found to be 26.36%. Conclusion: Assessment of medication usage patterns using the WHO core indicators in CKD patients helps to reinforce the current hospital guidelines for the optimal usage of medications. The introduction of a clinical pharmacist along with a multidisciplinary team provides intensive care to the patients and helps to improve the clinical outcome.

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Drug Utilisation Pattern and Adverse Events in Patients with Chronic Kidney Disease Undergoing Maintenance Haemodialysis at a Tertiary Care Hospital of Odisha

Cited by 7 publications

References 0 publications

Analysis of prescription pattern in patients on maintenance hemodialysis

Analysis of prescription pattern in patients on maintenance hemodialysis

Study of Antihypertensive Drug Utilization Pattern in Chronic Kidney Disease Patients

A Prospective Observational Study on Medication Use Pattern in Patients With Risk Factors of Chronic Kidney Disease

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