Drug treatment of chronic insomnia — dawn at the end of a long night?

Wilson, Susan J.; Nutt, DJ

doi:10.1177/0269881108096605

J Psychopharmacol

2008

DOI: 10.1177/0269881108096605

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Drug treatment of chronic insomnia — dawn at the end of a long night?

Susan J. Wilson

DJ Nutt

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Cited by 3 publications

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Current Clinical Practice of Insomnia

Choi

Lim

2013

Ewha Med J

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Insomnia is one of the most common sleep disorders, which is leading to significant clinical distress and impairment of daytime functioning and decreasing quality of life. This article reviews the current clinical treatment options of insomnia. Non-pharmacological treatment including stimulus control, sleep restriction, cognitive therapy, relaxation training, and education of sleep hygiene should be considered first for treatment of insomnia. Psychological and behavioral interventions tend to have longer-lasting treatment benefits, while drugs show immediate improvement of sleep disturbance. In pharmacotherapy, benzodiazepine receptor agonist, melatonin receptor antagonist, and ' off-label' drugs to treat insomnia are reviewed. (Ewha Med J 2013;36(2):84-92)

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Current Clinical Practice of Insomnia

Choi

Lim

2013

Ewha Med J

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A user-centred design process to develop technology to improve sleep quality in residential care homes

Carey-Smith

Evans

Orpwood

2013

TAD

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Pharmacotherapy of Insomnia

Kim

2009

J Korean Med Assoc

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A s insomnia is a common symptom caused by diverse disorders, treatment tools for the insomnia differ depending on the underlying cause. Hypnotics can be used for primary insomnia. As hypnotics show excellent short-term efficacy, they would be useful as short-term (< 4 weeks) treatments for transient insomnia. There has been much controversy over long-term hypnotic use for chronic insomnia. Evidence supporting safety and efficacy of the long-term hypnotic use is insufficient. Therefore, rather than using hypnotics alone, non-pharmacological treatments are recommended more for chronic primary insomnia. Although various benzodiazepines have widely been used as hypnotics, there have been concerns over tolerance, rebound insomnia, dependency, cognitive decline and psychomotor slowness. In efforts to relieve these concerns, selective benzodiazepine agonists like zolpidem have been introduced as novel hypnotics. Sedating antidepressants, melatonin and anti-histamine have also been used in order to manage insomnia. However, their efficacy for primary insomnia has yet to be proven.Keywords: Insomnia; Benzodiazepine; Zolpidem; Pharmacotherapy Abstract

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Drug treatment of chronic insomnia — dawn at the end of a long night?

Cited by 3 publications

References 33 publications

Current Clinical Practice of Insomnia

Current Clinical Practice of Insomnia

A user-centred design process to develop technology to improve sleep quality in residential care homes

Pharmacotherapy of Insomnia

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