2018
DOI: 10.1016/j.ejps.2017.12.012
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Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system

Abstract: In this study, chitosan-alginate polyelectrolyte microparticles containing the antibiotic, vancomycin chloride were prepared using the ionotropic gelation (coacervation) technique. In vitro release and drug transport mechanisms were studied concerning the chitosan only and alginate only microparticles as a control group. Further, the effect of porosity on the drug transport mechanism was also studied for chitosan-alginate mixed particles produced by lyophilizing in contrast to the air-dried non-porous particle… Show more

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Cited by 297 publications
(170 citation statements)
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“…The ratio of the relaxational to the diffusional behavior (R/F) of NPs is depicted in Figure 6. Except for MTX-PAM-2Na, the diffusional component prevailed for most NPs [70]. Further, NPs produced with PAM-18 showed the largest diffusional contribution to MTX release, showing the largest drug retention, whereas NPs produced with PAM-2 anions showed more relaxation/gelling contribution, easing drug release.…”
Section: Polymer Free Mtx Mtx-pam-2k Mtx-pam-2na Mtx-pam-18k Mtx-pam-mentioning
confidence: 96%
“…The ratio of the relaxational to the diffusional behavior (R/F) of NPs is depicted in Figure 6. Except for MTX-PAM-2Na, the diffusional component prevailed for most NPs [70]. Further, NPs produced with PAM-18 showed the largest diffusional contribution to MTX release, showing the largest drug retention, whereas NPs produced with PAM-2 anions showed more relaxation/gelling contribution, easing drug release.…”
Section: Polymer Free Mtx Mtx-pam-2k Mtx-pam-2na Mtx-pam-18k Mtx-pam-mentioning
confidence: 96%
“…24 More recently, alginatechitosan loaded drugs have been developed to improve the bioavailability of a large number of drugs. [19][20][21][22][23][24]26,27 Mean Particle Size, Poly Disparity Index, and Zeta Potential…”
Section: Results and Discussion Formulation Development And Optimizationmentioning
confidence: 99%
“…41 In addition, the observed pH-dependent pattern was consistent with the previously described drug release behavior of indomethacin-crosslinked chitosan-Malginate microspheres, in which a higher pH caused lower rates of indomethacin release due to greater crosslinking in the microspheres. 27 Protonation of the amine groups of the drug is known to improve solubility in an acidic medium. At low pH, alginate and chitosan are known to exist in a gel form, while at neutral pH, the viscous complex will swell and the gel will slowly disintegrate, thus causing the drug to be released.…”
Section: In Vitro Release Studiesmentioning
confidence: 99%
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“…To study the indometacin release from capsules the kinetic model of Ritger -Peppas [56] has been used. This simple semi-empirical model is fully sufficient for spherical delivery systems [57][58][59] and given by equation: is a constant incorporating structural and geometric characteristics of the particles, and n is the release exponent, indicative of the mechanism of drug release. In the case of spherical delivery systems when n = 0.43 drug release mechanism is Fician diffusion.…”
Section: Release Of Indomethacin From Polyelectrolyte Capsulesmentioning
confidence: 99%