Polyelectrolyte nanocontainers: Controlled binding and release of indomethacin

Abstract

Herein, polyelectrolyte capsules containing anti-inflammatory drug indomethacin were formed using layer-by-layer strategy, which involves alternative deposition of oppositely charged polyelectrolytes, such as poly(acrylic acid) and poly(ethyleneimine) (or chitosan) onto the drug substrate. Two variants of encapsulation have been implemented: direct deposition of polyelectrolytes onto indomethacin dispersed in water at рН 6, and preliminary formation of soft matrix by solubilization of indomethacin in micellar solutions of cationic surfactants. The inclusion of indomethacin into nanosized polyelectrolyte capsules (hydrodynamic diameter of three-and five-layer capsules is 90-180 nm) has given a new form of indomethacin with the drug content of 0.20-0.25%, which exceeds its limiting solubility in water nearly by the factor of 40. The choice of materials and procedures used for preparation of capsules, as well as the number of polyelectrolyte layers that form shell has provided the control of the drug release from capsule and resulted in the design of pharmaceutical dosage forms with long-lasting effect.

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

“…Lipophilic substance can be effectively loaded by dissolving in the organic phase of nanoemulsion [ 44 ]. Positive or negative charged oleic surfactants are commonly used for nanoemulsion preparation to provide a charged interfacial for the deposition of polyelectrolyte layer [ 16 , 119 ]. Taking advantages of the unique multilayer-core nanostructure, the nanocapsules formulated by LBL technique can also carrier different payloads at different position simultaneously.…”

Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability

“…This approach has been used in the layer-by-layer protocol, in which a micellar core composed of cationic surfactants was used as a template for the deposition of polyanion/polycation pairs. In this case, multiple tasks can be achieved: (i) hydrophobic guest solubilization; (ii) stabilization of a micellar nanocontainer loaded with drug or probe; (iii) the electrostatic promotion of adsorption of the first oppositely charged polyelectrolyte layer [95][96][97][98].…”

Microemulsions and nanoemulsions modified with cationic surfactants for improving the solubility and therapeutic efficacy of loaded drug indomethacin

“…Polymeric poly(glycerol-adipate-co-ɷ-pentadecalactone) microparticles coated with Eudragit L100-55 [24] and polymeric hydrogel coating based on poly(3-mercaptopropyl)trimethoxysilane-co-acrylic acrylate and polyvinyl alcohol [25] were used for indomethacin encapsulation and release. Biocompatible polyelectrolyte capsules for control release of indomethacin were formed using a layer-by-layer strategy, which involves the alternative depositions of oppositely charged polyelectrolytes, such as poly(acrylic acid) and poly (ethyleneimine) (or chitosan) onto the drug substrate [26]. Several authors focused on indomethacin delivery systems composed of silica such as mesoporous silica nanoparticles [27], carbopol coated spherical mesoporous silica particles [28], Eudragit and hydroxypropyl methylcellulose amorphous solid dispersions [29], mesoporous silica cocoon materials [30] and silica xerogel [31].…”