Drug Transport Across Blood-Ocular Barriers and Pharmacokinetics

Cunha‐Vaz, José; Marques, Francisco Batel; Fernandes, Rosa; Alves, Carlos; Velpandian, Thirumurthy

doi:10.1007/978-3-319-25498-2_3

Cited by 7 publications

(4 citation statements)

References 84 publications

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“…Even though each of the routes is effective in particular diseases scenario, these routes of delivery have serious disadvantages and limitations. For example, blood-ocular barriers [114] significantly decrease the permeation of systemically administered drugs, necessitating high doses of medications which can be toxic or cause severe side effects. The surgical implantation of sustained release drug vehicles, as with any surgical intervention, is highly invasive and is performed only in absence of the effective alternatives.…”

Section: Ocular Applications Of Microneedlesmentioning

confidence: 99%

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Rzhevskiy

Singh

Donnelly

et al. 2018

Journal of Controlled Release

189

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Microneedles is the technique of drug delivery enhancement, which was primarily designed for facilitating percutaneous drug delivery. Started from the development of simple solid microneedles, providing microporation of stratum corneum and therefore enhancement of topical drug delivery, for two decades the technique has progressed in various modifications such as hollow, coated, dissolving and hydrogel forming microneedles. In their turn, the modifications have resulted in new mechanisms of drug delivery enhancement and followed by the expansion of applicability range in terms of targeted tissues and organs. Thus, in addition to percutaneous drug delivery, microneedles have been considered as an efficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vaginal drug administration. It is anticipated that the technique of microneedle-assisted drug delivery will soon become relevant for majority of organs and tissues.

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Section: Ocular Applications Of Microneedlesmentioning

confidence: 99%

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Rzhevskiy

Singh

Donnelly

et al. 2018

Journal of Controlled Release

189

View full text Add to dashboard Cite

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“…Specifically, the blood-aqueous barrier forms tight junctions that regulate the exchange of solutes between the anterior and posterior segments, thus impeding nonspecific drug penetration into the inner ocular tissues. [47,48] …”

Section: Routes Of Ocular Administrationmentioning

confidence: 99%

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation

Ratay

Bellotti

Gottardi³

et al. 2017

Adv Healthcare Materials

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Dry eye disease (DED), age-related macular degeneration (AMD), and Uveitis are ocular diseases that significantly affect the quality of life of millions of people each year. In these diseases, the action of chemokines, pro-inflammatory cytokines, and immune cells drives a local inflammatory response that results in ocular tissue damage. Multiple therapeutic strategies have been developed to either address the symptoms or abate the underlying cause of these diseases. Herein, we will review the challenges to deliver drugs to the relevant location in the eye for each of these diseases as well as current and innovative therapeutic approaches that attempt to restore homeostasis within the ocular microenvironment.

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“…Ocular drug delivery has three conventional approaches, topical application, intraocular injection, and systemic administration, with certain drawbacks when effectively delivering medication to the posterior segment of the eye [13]. Other avenues for administering drugs to the eye involve surgically implanting drug carriers to enable prolonged drug release into ocular or periocular tissues and precise topical administration through injections and conventional topical applications [14,15]. Nanotechnology could improve ocular therapy by addressing issues like poor intraocular penetration and rapid ocular elimination in traditional drug delivery routes [16].…”

Section: Introductionmentioning

confidence: 99%

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Rojekar,

Parit,

Gholap

et al. 2024

Preprint

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Microneedle technology is a novel platform technology that revolutionizes ocular drug delivery and addresses critical challenges in the treatment of ocular diseases. Routine treatment methods, such as eye drops and intravitreal injections, suffer from low bioavailability and poor patient compliance. So, novel advanced platform technologies are required to overcome these challenges. Microneedle is a minimally invasive and promising alternative technique that helps precisely control drug delivery to targeted tissues and organs. This review investigates the potential impact of microneedle technology for eye care, underscoring recent advancements, underlying mechanisms, and emerging preclinical and clinical uses. Different types of microneedles, including solid, coated, dissolvable, and hollow, have demonstrated their potential and capability to bypass several barriers in the cornea and sclera. This ensures effective drug penetration and delivery. The current innovations in material science and fabrication methods have enhanced the safety and efficacy of microneedles, reducing discomfort and the chances of infections. These microneedle technologies offer sustained and controlled drug delivery, which could improve therapeutic outcomes for various disease conditions like age-related macular degeneration, glaucoma, diabetic neuropathy, etc. In the current review, recent preclinical and clinical studies emphasize microneedle-based ocular drug delivery's feasibility and potential benefits. These include improved pharmacokinetics, reduced dosing frequency, enhanced patient adherence, and, most importantly, microneedles offer versatile platforms for delivering a wide range of small and large molecules and gene therapies. Despite the exciting progress, obstacles such as regulatory barriers, scalability, and long-term biocompatibility persist. It will be essential to tackle these challenges through interdisciplinary research and partnerships to integrate microneedle technology into standard clinical use effectively. Ultimately, microneedle drug delivery offers a revolutionary method that has the potential to significantly enhance the treatment and results of ocular diseases, marking the dawn of a new era in eye care.

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Drug Transport Across Blood-Ocular Barriers and Pharmacokinetics

Cited by 7 publications

References 84 publications

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

Modern Therapeutic Approaches for Noninfectious Ocular Diseases Involving Inflammation

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

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